2 Results for "

Verticilide

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Verticilide" in MCE Product Catalog:

Cat. No.: HY-N7491A
CAS No.: 2056011-05-1
Target:  

Calcium Channel

Research Areas:  

Cancer

ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca2+ leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine. ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
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Cat. No.: HY-N7491
CAS No.: 693778-57-3
Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC50 value of 4.2 μM (whereas inhibition against mouse ryanodine receptors was weak (IC50=53.9 μM)) .
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