Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
XZ 338
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "XZ 338" in MCE Product Catalog:
Cat. No.: HY-172798
Target:
Research Areas:
XZ338 is a highly potent and selective BCL-XL PROTAC degrader derived from A-1331852 (HY-19741), with a DC50 of 0.43 nM in MOLT‑4 cells. XZ338 induces the formation of a ternary complex with BCL-XL and VHL E3 ligase, mediates target protein degradation via the ubiquitin-proteasome system, and exhibits significantly weaker degradation activity in platelets than in tumor cells. XZ338 possesses anti-cancer activity. XZ338 can be used in the research of T-cell acute lymphoblastic leukemia (T-ALL) .
Cat. No.: HY-172799
Target:
Research Areas:
8-Sulfamoyloctanoic acid is a PROTAC linker that can be used in the synthesis of PROTAC XZ338 (HY-172798) .
Cat. No.: HY-172800
Research Areas:
(S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid is an E3 ubiquitin ligase ligand-linker conjugate. (S,R,S)-AHPC-Me-8-Sulfamoyloctanoic acid can be used for the synthesis of XZ338 (HY-172798) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
