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Results for "

angiotensin II receptor antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Angiotensin Receptor (118) Angiotensin-converting Enzyme (ACE) (1) Androgen Receptor (2) Apoptosis (4) Autophagy (8) Calcium Channel (3) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (3) Endothelin Receptor (3) Isotope-Labeled Compounds (16) Mineralocorticoid Receptor (2) Neprilysin (2) Orphan GPCR (1) P2Y Receptor (4) PDGFR (1) Reactive Oxygen Species (ROS) (3) Reference Standards (15) Renin (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (115) Endocrinology (40) Infection (1) Inflammation/Immunology (8) Metabolic Disease (10) Neurological Disease (5)

By Targets:

Angiotensin Receptor (118)

Angiotensin-converting Enzyme (ACE) (1)

Androgen Receptor (2)

Apoptosis (4)

Autophagy (8)

Calcium Channel (3)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (3)

Endothelin Receptor (3)

Isotope-Labeled Compounds (16)

Mineralocorticoid Receptor (2)

Neprilysin (2)

Orphan GPCR (1)

P2Y Receptor (4)

PDGFR (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (15)

Renin (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (115)

Endocrinology (40)

Infection (1)

Inflammation/Immunology (8)

Metabolic Disease (10)

Neurological Disease (5)

129

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Angiotensin Receptor Photosystem II Angiotensin-converting Enzyme (ACE) CD74

Art. -Nr.	Produktname	Target	Forschungsgebiete	Chemical Structure

HY-17512

Losartan Maximum Cited Publications 54 Publications Verification DuP-753	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan is an **angiotensin II receptor** antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512A

Losartan potassium Maximum Cited Publications 54 Publications Verification DuP-753 potassium	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-18204

Valsartan 20+ Cited Publications CGP 48933	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-13955

Telmisartan 15+ Cited Publications BIBR 277	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology Cancer
Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17004

Olmesartan 10+ Cited Publications RNH-6270	Angiotensin Receptor	Cardiovascular Disease
Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure .

HY-17621

Sparsentan RE-021; DARA-a	Angiotensin Receptor Endothelin Receptor	Cardiovascular Disease Endocrinology
Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K_is of 0.8 and 9.3 nM, respectively .

HY-117743

Eprosartan 4 Publications Verification SKF-108566J free base	Angiotensin Receptor	Cardiovascular Disease
Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active **angiotensin II receptor** antagonist, used as an antihypertensive. Eprosartan binds **angiotensin II receptor with IC₅₀**s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-15834A

Eprosartan mesylate 4 Publications Verification SKF-108566J	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Eprosartan mesylate (SKF-108566J) is a selective, competitive, nonpeptid and orally active **angiotensin II receptor** antagonist, used as an antihypertensive. Eprosartan mesylate binds **angiotensin II receptor with IC₅₀**s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-160187

AAA	Orphan GPCR Angiotensin Receptor	Cardiovascular Disease
AAA is an orally active 20-HETE receptor antagonist. AAA exerts antihypertensive and organoprotective effects. AAA blocks 20-HETE prohypertensive actions, suppresses intrarenal and circulating angiotensin II levels, and interferes with renin-angiotensin system interactions. AAA attenuates development of, and reverses established, ANG II (HY-13948)-dependent malignant hypertension. AAA reduces albuminuria, glomerulosclerosis, and cardiac hypertrophy linked to malignant hypertension. AAA can be used for the research of malignant hypertension .

HY-12765

Losartan Carboxylic Acid E-3174; EXP-3174	Drug Metabolite Angiotensin Receptor	Cardiovascular Disease
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .

HY-A0250

Tasosartan WAY-ANA 756	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Tasosartan is a long-acting angiotensin II (AngII) *receptor* antagonist.

HY-10259A

PD 123319 ditrifluoroacetate 10+ Cited Publications	Angiotensin Receptor	Cardiovascular Disease Endocrinology
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC₅₀ of 34 nM.

HY-P0205

Saralasin [Sar1,Ala8] angiotensin II	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-14736

Azilsartan medoxomil 2 Publications Verification TAK-491	Angiotensin Receptor	Cardiovascular Disease Infection Metabolic Disease Cancer
Azilsartan medoxomil (TAK 491), a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil can be used for the study of essential hypertension .

HY-17458

Azilsartan medoxomil monopotassium 2 Publications Verification Azilsartan kamedoxomil; TAK 491 monopotassium	Angiotensin Receptor	Cardiovascular Disease Metabolic Disease Cancer
Azilsartan medoxomil (TAK 491) monopotassium, a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil monopotassium can be used for the study of essential hypertension .

HY-P0205B

Saralasin TFA [Sar1,Ala8] angiotensin II TFA	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin TFA can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-102093

ZD 7155hydrochloride 1 Publications Verification	Angiotensin Receptor	Cardiovascular Disease Endocrinology
ZD 7155 hydrochloride is an angiotensin II receptor type 1 (AT1 receptor) antagonist.

HY-17512S

Losartan-d4 DuP-753 d₄	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-17512AR

Losartan potassium (Standard) DuP-753 potassium (Standard)	Reference Standards Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Losartan (potassium) (Standard) is the analytical standard of Losartan (potassium). This product is intended for research and analytical applications. Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-121767

PD 123177	Angiotensin Receptor	Cardiovascular Disease
PD 123177 is a nonpeptide antagonist specific for **angiotensin II (AII) subtype AT2 receptor** in mammalian systems .

HY-135363

Valsartan Ethyl Ester 2 Publications Verification	Angiotensin Receptor	Cardiovascular Disease
Valsartan Ethyl Ester is an impurity of Valsartan. Valsartan is an angiotensin II receptor antagonist for the treatment of high blood pressure and heart failure .

HY-17004S1

Olmesartan-d6 RNH-6270-d₆	Isotope-Labeled Compounds Angiotensin Receptor	Cardiovascular Disease
Olmesartan-d₆ (RNH-6270-d₆) is the deuterium labeled Olmesartan. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure .

HY-14914S

Azilsartan-d5 TAK-536-d₅	Angiotensin Receptor	Others
Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

HY-W098792

Candesartan methyl ester	Angiotensin Receptor	Cardiovascular Disease
Candesartan methyl ester (compound 14) is an antagonist for **angiotensin II (AII) receptor with an IC₅₀** of 66 nM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models .

HY-B0202S1

Irbesartan-d6	Angiotensin Receptor Apoptosis	Cardiovascular Disease Endocrinology
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-18204S2

Valsartan-d8 CGP 48933-d₈	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Valsartan-d₈ is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-P10933

PRO20	Renin	Cardiovascular Disease
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC₅₀ value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents .

HY-101574

Pratosartan FW 7203; KD 3-671; KT 3671	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Pratosartan is a selective **angiotensin II receptor** antagonist.

HY-10259

PD 123319 (S)-(+)-PD 123319	Angiotensin Receptor	Cardiovascular Disease Endocrinology
PD 123319 (ditrifluoroacetate) is a potent, selective AT2 angiotensin II receptor antagonist with IC₅₀ of 34 nM.

HY-B0205S1

Candesartan-d5	Angiotensin Receptor	Cardiovascular Disease Endocrinology Cancer
Candesartan-d₅ is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

HY-18204S

Valsartan-d9 CGP 48933-d₉	Angiotensin Receptor	Cardiovascular Disease Endocrinology
Valsartan-d₉ is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-18204S1

Valsartan-d3 CGP 48933-d₃	Angiotensin Receptor	Cardiovascular Disease
Valsartan-d₃ is the deuterium labeled Valsartan . Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-17004S

Olmesartan-d4 RNH-6270-d₄	Angiotensin Receptor	Others
Olmesartan-d₄ (RNH-6270-d₄) is the deuterium labeled Olmesartan (HY-17004). Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-13955S2

Telmisartan-13C,d3 BIBR 277-¹³C,d₃	Isotope-Labeled Compounds Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-17512S3

Losartan-d2 DuP-753-d₂	Angiotensin Receptor	Others
Losartan-d₂ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-19165

CI-996	Angiotensin Receptor	Cardiovascular Disease
CI-996 is a potent, selective, orally active **angiotensin II (Ang II) type 1 (AT1) receptor** antagonist. In rat liver membranes CI-996 displaces specifically bind [ ¹²⁵I]Ang II with an IC₅₀ of 0.8 nM. CI-996 has blood pressure-lowering activity .

HY-13955S

Telmisartan-d3	Angiotensin Receptor Autophagy	Cardiovascular Disease Endocrinology
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S3

Telmisartan-d7 BIBR 277-d₇	Isotope-Labeled Compounds Autophagy Angiotensin Receptor	Cardiovascular Disease
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-P11389

(Sar1,Gly8)-Angiotensin II	Angiotensin Receptor	Neurological Disease
(Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (K_i: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II .

HY-119544

Ripisartan UP-2696	Angiotensin Receptor	Cardiovascular Disease
Ripisartan (UP-2696) is an **angiotensin II receptor** antagonist. Ripisartan is orally available. Ripisartan binds to angiotensin II receptors, dilates blood vessels, and lowers blood pressure .

HY-105453

PD 121981 WL 19	Angiotensin Receptor	Cardiovascular Disease
PD 121981 is a **angiotensin II receptor** antagonist. PD 121981 can be used for the research of cardiovascular disease .

HY-P0205A

Saralasin acetate hydrate [Sar1,Ala8] angiotensin II acetate hydrate	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-10382

EXP-6803	Angiotensin Receptor	Cardiovascular Disease
EXP-6803 is a specific nonpeptide angiotensin II receptor antagonist with antihypertensive activity. EXP-6803 inhibits the contractile response to angiotensin II with a pA₂ value of 7.20. EXP-6803 effectively blocks responses to angiotensin I and II while not affecting responses to bradykinin or acetylcholine in guinea pig ileum. EXP-6803 can be used for hypertension research .

HY-108120

L-162537	Angiotensin Receptor	Cardiovascular Disease
L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC₅₀=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension .

HY-131277

Dehydro Olmesartan	Angiotensin Receptor	Cardiovascular Disease
Dehydro Olmesartan is a derivative of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study .

HY-105010

FK-739 free base	Angiotensin Receptor	Cardiovascular Disease
FK-739 (free base) is an angiotensin II type 1 (AT1) receptor antagonist used in the study of hypertension .

HY-Z0061

Valsartan benzyl ester	Drug Intermediate	Others
Valsartan benzyl ester is an intermediate of Valsartan (HY-18204). Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-131276

Olmesartan lactone impurity	Angiotensin Receptor	Cardiovascular Disease
Olmesartan lactone impurity is a cyclic ester impurity of Olmesartan. Olmesartan is an angiotensin II receptor (AT1R) antagonist and has the potential for high blood pressure study .

HY-105506

EXP-7711	Angiotensin Receptor	Cardiovascular Disease
EXP-7711 is a non peptide **angiotensin II (Ang II) AT1 receptor** antagonist. EXP-7711’s affinity for wild-type AT1 receptor (K_i =180 nM) is lower than peptide antagonists, but higher than losartan (K_i = 12 nM). EXP-7711 can be used for research on cardiovascular conditions .

HY-117858

CL-329167	Angiotensin Receptor	Cardiovascular Disease
CL-329167 (compound 12) is an orally active and competitive **angiotensin II receptor** antagonist (IC₅₀=6 nM). CL-329167 can be used in the research of hypertension .

Art. -Nr.	Produktname	Target	Research Area

HY-P0205

Saralasin [Sar1,Ala8] angiotensin II	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) is an octapeptide analog of angiotensin II. Saralasin is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-P0205B

Saralasin TFA [Sar1,Ala8] angiotensin II TFA	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) TFA is an octapeptide analog of angiotensin II. Saralasin TFA is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin TFA can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

HY-P10933

PRO20	Renin	Cardiovascular Disease
PRO20 is a specific and competitive (pro)renin receptor (PRR) antagonist. PRO20 inhibits Prorenin-induced calcium influx with an IC₅₀ value of 81 nmol/L. PRO20 exerts antihypertensive activity by blocking the binding of prorenin to the PRR, inhibiting the activation of the renin-angiotensin system (RAS), and reducing the production of angiotensin II (Ang II). PRO20 is promising for research of antihypertensive agents .

HY-P11389

(Sar1,Gly8)-Angiotensin II	Angiotensin Receptor	Neurological Disease
(Sar1,Gly8)-Angiotensin II is an AT1 angiotensin II receptor subtype selective antagonist (K_i: 52 nM for AT2 receptor in rat adrenal). (Sar1,Gly8)-Angiotensin II potently antagonizes dipsogenic responses to intracerebroventricularly administered Ang II .

HY-P0205A

Saralasin acetate hydrate [Sar1,Ala8] angiotensin II acetate hydrate	Angiotensin Receptor	Cardiovascular Disease Inflammation/Immunology
Saralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive **angiotensin II receptor** antagonist with a K_i value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension .

Art. -Nr.	Produktname	Category	Target	Chemical Structure

HY-N14205

Cytosporin A	Natürliche Produkte Microorganisms Source Classification	Angiotensin Receptor
Cytosporin A is a hexahydrobenzopyran derivative and an **angiotensin II receptor** antagonist. Cytosporin A has IC₅₀ values of 25-30 μM and 1.5-3 μM for AT₁ and AT₂, respectively .

HY-N9520

1-Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Quinoline Alkaloids Plants Disease Research Fields Source Classification	Angiotensin Receptor
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is an antagonist of **angiotensin II receptor (IC₅₀**=48.2 μM). Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9 is a quinolone alkaloid from Evodia rutaecarpa .

Art. -Nr.	Produktname	Chemical Structure

HY-17512S

Losartan-d4
Losartan-d₄ is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

HY-17004S1

Olmesartan-d6
Olmesartan-d₆ (RNH-6270-d₆) is the deuterium labeled Olmesartan. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure .

HY-12765S

Losartan-d4 (carboxylic acid)

Losartan-d₄ carboxylic acid (E-3174-d₄) is the deuterium labeled Losartan Carboxylic Acid (HY-12765). Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.

HY-14914S

Azilsartan-d5
Azilsartan-d₅ is the deuterium labeled Azilsartan(TAK-536), which is a specific and potent angiotensin II type 1 receptor antagonist.

HY-B0202S1

Irbesartan-d6
Irbesartan-d₆ is the deuterium labeled Irbesartan. Irbesartan is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist with IC50 of 1.3 nM.

HY-18204S2

Valsartan-d8
Valsartan-d₈ is the deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-B0205S1

Candesartan-d5
Candesartan-d₅ is the deuterium labeled Candesartan. Candesartan is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

HY-18204S

Valsartan-d9
Valsartan-d₉ is deuterium labeled valsartan. Valsartan is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-18204S1

Valsartan-d3
Valsartan-d₃ is the deuterium labeled Valsartan . Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-17004S

Olmesartan-d4
Olmesartan-d₄ (RNH-6270-d₄) is the deuterium labeled Olmesartan (HY-17004). Olmesartan is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.

HY-13955S2

Telmisartan-13C,d3
Telmisartan- ¹³C,d₃ is the ¹³C- and deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

HY-17512S3

Losartan-d2
Losartan-d₂ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-13955S

Telmisartan-d3
Telmisartan-d₃ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-13955S3

Telmisartan-d7
Telmisartan-d₇ (BIBR 277-d₇) is a deuterium labeled Telmisartan (HY-13955). Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of ¹²⁵I-AngII to AT1 receptors with IC₅₀ of 9.2 nM.

HY-17621S

Sparsentan-d5
Sparsentan-d₅ is deuterium labeled Sparsentan. Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with K_is of 0.8 and 9.3 nM, respectively .

HY-14914S1

Azilsartan-d4
Azilsartan-d₄ is the deuterium labeled Azilsartan . Azilsartan is an orally active, potent, selective and specific angiotensin II type 1 receptor (AT1) antagonist. Azilsartan induces ROS formation and apoptosis in HepG2 cells. Azilsartan shows neuroprotective and anticancer activity. Azilsartan can be used for hypertension and stroke research .

HY-B0561S4

Spironolactone-d6-1

Spironolactone-d₆-1 is the deuterium labeled Spironolactone (HY-B0561). Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC₅₀=24 nM) and androgen receptor (IC₅₀=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca ²⁺ channels to exert antihypertensive effects .

HY-17512S1

Losartan-d3 Carboxylic Acid
Losartan-d₃ Carboxylic Acid is the deuterium labeled Losartan. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512S4

Losartan-d9
Losartan-d₉ is the deuterium labeled Losartan . Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC₅₀ of 20 nM.

HY-17512AS

Losartan-d6 hydrochloride
Losartan-d₆ hydrochloride is deuterated labeled Losartan potassium (HY-17512A). Losartan potassium (DuP-753 potassium) is an angiotensin II receptor type 1 (AT1) antagonist, competing with the binding of angiotensin II to AT1 with an IC₅₀ of 20 nM.

HY-117743S

Eprosartan-d3
Eprosartan-d₃ is the deuterium labeled Eprosartan. Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active angiotensin II receptor antagonist, used as an antihypertensive. Eprosartan binds angiotensin II receptor with IC₅₀s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-117743S1

Eprosartan-d6
Eprosartan-d₆ is deuterated labeled Eprosartan (HY-117743). Eprosartan (SKF-108566J free base) is a selective, competitive, nonpeptid and orally active **angiotensin II receptor** antagonist, used as an antihypertensive. Eprosartan binds **angiotensin II receptor with IC₅₀**s of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively .

HY-18204S3

(Rac)-Valsartan-d9
(Rac)-Valsartan-d₉ is deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research .

HY-13955S1

Telmisartan-d4
Telmisartan-d₄ is the deuterium labeled Telmisartan. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC₅₀ of 9.2 nM .

HY-12765S1

Losartan carboxylic acid-d4 hydrochloride

Losartan carboxylic acid-d₄ (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The K_i values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure .

HY-107867S1

(Rac)-Clopidogrel hydrogen-d9 sulfate

(Rac)-Clopidogrel hydrogen-d₉ sulfate is the deuterium labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .

HY-107867S2

Clopidogrel-13C,d3 sulfate

Clopidogrel- ¹³C,d₃ sulfate is the deuterium and ¹³C-labeled (±)-Clopidogrel (bisulfate) (HY-107867). (±)-Clopidogrel bisulfate is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel bisulfate inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel bisulfate reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel bisulfate has anti-inflammatory effects .

HY-145552S

Azilsartan mepixetil-d5

Azilsartan mepixetil-d₅ (QR-01019-d₅) is deuterium labeled Azilsartan mepixetil. Azilsartan mepixetil is the antagonist of angiotensin II receptor. Azilsartan mepixetil has stronger and longer blood pressure effect, more abvious and longer lasting heart rate lowering effect and high safety. Azilsartan mepixetil achieves ideal protective effect for heart and kidney functions. Azilsartan mepixetil has the potential for the research of hypertension, chronic heart failure and diabetic nephropathy (extracted from patent CN107400122A) .

HY-15283AS1

(±)-Clopidogrel-d4

(±)-Clopidogrel-d₄ ((±)-Clopidogrelum-d₄) is the deuterium labeled (±)-Clopidogrel (HY-107867). (±)-Clopidogrel is a platelet P2Y12 receptor inhibitor and an adenosine diphosphate (ADP) receptor antagonist. (±)-Clopidogrel inhibits the binding of ADP to its receptors on the membranes of platelet cells, and blocks ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (±)-Clopidogrel reduces vascular inflammation and angiotensin II induced-abdominal aortic aneurysm progression. (±)-Clopidogrel has anti-inflammatory effects .

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