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Results for "

anti-invasive

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Autophagy (3) Cadherin (2) Environmental Pollutants (2) ERK (1) Ferlin Family (2) FGFR (1) Fungal (1) GABA Receptor (2) Glycosyltransferase (1) HDAC (2) Isotope-Labeled Compounds (1) Kallikrein (1) LIM Kinase (LIMK) (1) Mitochondrial Metabolism (1) MMP (8) Myosin (1) NF-κB (3) Oxidative Phosphorylation (1) Parasite (2) Phosphodiesterase (PDE) (1) Potassium Channel (1) Progesterone Receptor (1) Reactive Oxygen Species (ROS) (4) Reference Standards (2) Ser/Thr Protease (1) β-catenin (1)
By Research Areas:	Cancer (26) Infection (3) Inflammation/Immunology (2) Neurological Disease (4)

By Targets:

Apoptosis (5)

Autophagy (3)

Cadherin (2)

Environmental Pollutants (2)

ERK (1)

Ferlin Family (2)

FGFR (1)

Fungal (1)

GABA Receptor (2)

Glycosyltransferase (1)

HDAC (2)

Isotope-Labeled Compounds (1)

Kallikrein (1)

LIM Kinase (LIMK) (1)

Mitochondrial Metabolism (1)

MMP (8)

Myosin (1)

NF-κB (3)

Oxidative Phosphorylation (1)

Parasite (2)

Phosphodiesterase (PDE) (1)

Potassium Channel (1)

Progesterone Receptor (1)

Reactive Oxygen Species (ROS) (4)

Reference Standards (2)

Ser/Thr Protease (1)

β-catenin (1)

By Research Areas:

Cancer (26)

Infection (3)

Inflammation/Immunology (2)

Neurological Disease (4)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-N0803

Myrcene,75% (stabilized with BHT) β-Myrcene	Environmental Pollutants NF-κB	Others
Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-103444

ARP-100 1 Publications Verification	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .

HY-121618

α-Thujone	Environmental Pollutants GABA Receptor Parasite Reactive Oxygen Species (ROS) Apoptosis Autophagy	Infection Neurological Disease Inflammation/Immunology
α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC₅₀ for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and can cross the blood-brain barrier .

HY-134832

Mito-LND 3 Publications Verification Mito-Lonidamine	Oxidative Phosphorylation Mitochondrial Metabolism Reactive Oxygen Species (ROS) Autophagy	Cancer
Mito-LND (Mito-Lonidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation (OXPHOS). Mito-LND inhibits mitochondrial bioenergetics, stimulates the formation of reactive oxygen species, and induces autophagic cell death in lung cancer cells .

HY-115625

AG-205	Progesterone Receptor Apoptosis Glycosyltransferase	Cancer
AG-205 is a progesterone receptor membrane component 1 (PGRMC1) antagonist and CGT inhibitor, with an IC₅₀ of 50 μM against rat CGT. AG-205 exhibits antimitotic, antimigratory and anti-invasive activities. AG-205 increases the expression of genes encoding cholesterol biosynthesis pathway or steroidogenic enzymes. AG-205 promotes the regulation of cell cycle by apoptosis and reduces the migratory and invasive capacities of ovarian and breast cancer cells. AG-205 can be used in research related to renal cancer and breast cancer .

HY-N6862

Lucideric acid A	MMP	Cancer
Lucideric acid A is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-12168

Tanomastat BAY 12-9566	MMP	Cancer
Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The K_i values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .

HY-178521

BAS00602705	Cadherin	Cancer
BAS00602705 is an E-cadherin inhibitor. BAS00602705 exerts its function by blocking the trans-interactions of E-cadherin molecules within junctional complexes, without permanently altering E-cadherin expression levels. BAS00602705 significantly impairs invadopodia formation in pancreatic cancer cells. BAS00602705 can be used for the study of anti-invasive therapeutic strategies in cancers characterized by dysregulated E-cadherin-mediated invadopodia activity, such as pancreatic ductal adenocarcinoma (PDAC) .

HY-156019

FGFR1 inhibitor-10	FGFR	Cancer
FGFR1 inhibitor-10 (Compound 4i) is an FGFR1 inhibitor (IC₅₀: 28 nM). FGFR1 inhibitor-10 inhibits the phosphorylation of FGFR1. FGFR1 inhibitor-10 has anti-angiogenic, anti-invasion activity, and anti-tumor effect .

HY-143657

Myoferlin inhibitor 1	Myosin Ferlin Family MMP	Cancer
Myoferlin inhibitor 1 is a compound that exhibits reversible, concentration-dependent binding to the myoferlin MYOF-C2D protein, with a K_D of 0.094 μM. Myoferlin inhibitor 1 shows potent anti-invasion and anti-migration activities against different pancreatic cancer cells. Myoferlin inhibitor 1 inhibits pancreatic cancer metastasis through reversing mesenchymal transition (EMT), inhibiting the secretions of MMP1 and MMP2 and blocking the receptor tyrosine kinases. Myoferlin inhibitor 1 displays effective antimetastatic activities in pancreatic cancer in vitro and in vivo. Myoferlin inhibitor 1 can be used in research on preventing pancreatic cancer metastasis .

HY-N6776

Penitrem A	Potassium Channel	Neurological Disease Cancer
Penitrem A is an indole diterpene neurotoxic alkaloid produced by Penicillium, acts as a selective BK channel antagonist with antiproliferative and anti-invasive activities against multiple malignancies. Penitrem A increases the spontaneous release of endogenous glutamate, gamma-aminobutyric acid (GABA) and aspartate from cerebrocortical synaptosomes, and induces tremorgenic syndromes in animals .

HY-143539

YQ456	Ferlin Family	Cancer
YQ456 is a novel small molecule inhibitor of myoferlin that showed high binding affinity to myoferlin with a K_D of 37 nM and excellent anti-invasion capability with an IC₅₀ of 110 nM.

HY-N6860

Lucidenic acid C	MMP	Cancer
Lucidenic acid C is a natural compound isolated from Ganoderma lucidum, inhibits PMA-induced MMP-9 activity, with anti-invasive effect on hepatoma cells .

HY-N0803S

Myrcene-d6 β-Myrcene-d₆	NF-κB	Neurological Disease Cancer
Myrcene-d6 is the deuterium labeled Myrcene. Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-179418

Ceritinib-platinum(IV)-4-phenylbutyrate	Apoptosis	Cancer
Ceritinib-platinum(IV)-4-phenylbutyrate (complex 7) is a Ceritinib (HY-15656)-conjugated Platinum(IV) prodrug with anticancer activity. Ceritinib-platinum(IV)-4-phenylbutyrate induces S-phase arrest, DNA damage responses, and apoptosis. Ceritinib-platinum(IV)-4-phenylbutyrate combines cytotoxicity with immune and anti-invasive activation in cancer cell models. Ceritinib-platinum(IV)-4-phenylbutyrate can be used for cancer research, such as non-small cell lung cancer (NSCLC) .

HY-119726A

Fosmanogepix (tautomerism) APX001 (tautomerism); E1211 (tautomerism)	Fungal	Infection Inflammation/Immunology
Fosmanogepix tautomerism (APX001 tautomerism) is a broad-spectrum and orally active anti-invasive fungal compound. Fosmanogepix tautomerism targets the conserved Gwt1 enzyme required for the localization of glycosylphosphatidylinositol-anchored mannoproteins in fungi, and inhibition prevents proper localization of cell wall mannoproteins, thereby impairing cell wall integrity, biofilm formation, germ tube formation, and fungal growth. Fosmanogepix tautomerism can be used to study invasive fungal infections .

HY-123345

CRT 0105446	LIM Kinase (LIMK)	Cancer
CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC₅₀ of 8 nM .

HY-172136

LSQ-28	HDAC	Cancer
LSQ-28 is an orally active HDAC3 inhibitor with an IC₅₀ of 42 nM, and exhibits potent anticancer, antiproliferative, antimigratory, anti-invasive, and antiwound healing activities. LSQ-28 can be utilized in cancer research .

HY-103444R

ARP-100 (Standard)	Reference Standards MMP	Cancer
ARP-100 (Standard) is the analytical standard of ARP-100. This product is intended for research and analytical applications. ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC50=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .

HY-120896B

Imipramine Blue chloride	Reactive Oxygen Species (ROS)	Cancer
Imipramine Blue chloride is a potent anti-invasive agent. Imipramine Blue chloride inhibits the invasion of glioma. Imipramine Blue chloride inhibits NADPH oxidase-mediated reactive oxygen species generation .

HY-161284

MMP-9/10-IN-1	MMP	Cancer
MMP-9/10-IN-1 (Compound 6b) is a potent dual MMP-9/10 Inhibotor with IC₅₀s of 0.076 and 0.139 μM against NSCLC and A549 cells, respectively. MMP-9/10-IN-1 has anti-invasive and anti-angiogenic activities when in combination with Sorafenib (HY-10201) .

HY-N0803S1

Myrcene-13C3 β-Myrcene-¹³C₃	NF-κB Isotope-Labeled Compounds	Others
Myrcene- ¹³C₃ is ¹³C labeled Myrcene (HY-N0803). Myrcene (β-Myrcene) is a type of aromatic compound that inhibits TNFα and NF-κB activity. Myrcene has anti-invasive action, inhibits cell cycle, and leads to cancer cell apoptosis. Myrcene has strong blood protection effect, anti-inflammation, and anti-inflammatory activity .

HY-12168B

(Rac)-Tanomastat (Rac)-BAY 12-9566	MMP	Cancer
(Rac)-Tanomastat ((Rac)-BAY 12-9566) is the racemate of Tanomastat. Tanomastat (BAY 12-9566) is an orally bioavailable, non-peptidic biphenyl matrix metalloproteinases (MMPs) inhibitor with a Zn-binding carboxyl group. The K_i values are 11, 143, 301, and 1470 nM for MMP-2, MMP-3, MMP-9, MMP-13 respectively. Tanomastat shows anti-invasive and antimetastatic activity in several experimental tumor models .

HY-116264

CatB-IN-1	Ser/Thr Protease	Cancer
CatB-IN-1 is an enzyme inhibitor with significant inhibitory activity against tumor invasion. CatB-IN-1 may reduce the invasiveness of tumor cells by regulating intracellular protein metabolism. CatB-IN-1 demonstrates effective anti-invasive ability in cell models and can significantly reduce the invasive ability of MCF-10A neoT cells. The structure-activity relationship study of CatB-IN-1 shows that its design can target multiple functions of cat hepsin B .

HY-144125

Antitumor agent-41	Apoptosis	Cancer
Antitumor agent-41 (compound N-12), a potent antitumor agent, enhibits excellent antimigration and anti-invasion activity. Antitumor agent-41 (compound N-12) induces tumor inhibition via tumor necrosis and inflammatory response .

HY-121618R

α-Thujone (Standard)	GABA Receptor Reactive Oxygen Species (ROS) Parasite Apoptosis Autophagy Reference Standards	Infection Neurological Disease
α-Thujone (Standard) is the analytical standard of α-Thujone. This product is intended for research and analytical applications. α-Thujone is a monoterpene isolated from Thuja occidentalis essential oil with potent anti-tumor activities. α-Thujone is a reversible modulator of the GABA type A receptor and the IC50 for α-Thujone is 21 μM in suppressing the GABA-induced currents. α-Thujone induces ROS accumulation-dependent cytotoxicity, also induces cell apoptosis and autophagy. α-Thujone has antinociceptive, insecticidal, and anthelmintic activity, and easily penetrates the blood-brain barrier .

HY-156016

HDAC/CD13-IN-1	HDAC	Cancer
HDAC/CD13-IN-1 (Compound 12) is a HDAC/CD13 inhibitor (IC₅₀: 0.34 μM for hCD13, 0.53 μM for porcine CD13, 0.03, 0.06, 0.02 μM for HDAC1/2/3). HDAC/CD13-IN-1 inhibits MV4-11, K562, Jeko-1, and HL60 cell proliferation (IC₅₀: 0.25-2.04 μM). HDAC/CD13-IN-1 induces cancer cell apoptosis. HDAC/CD13-IN-1 has anti-metastasis and anti-invasion efficacy .

HY-N16719

Picrasidine J	Kallikrein ERK Cadherin β-catenin	Cancer
Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors .

HY-119601

GRI918013	Phosphodiesterase (PDE)	Cancer
GRI918013 (compound 1) is a selective and competitive autotaxin (ATX/NPP2) inhibitor with *anti-invasive and anti-metastatic* activity. GRI918013 competitively binds to ATX, blocking lipid substrates such as lysophosphatidylcholine (LPC) from entering the ATX active site, thereby inhibiting ATX-mediated hydrolysis of LPC to lysophosphatidic acid (LPA), and consequently inhibiting ATX-LPA axis-related tumor cell invasion and metastasis. GRI918013 inhibits ATX-mediated hydrolysis of the LPL substrate FS-3 (IC₅₀=31.42 nM, K_i=12.98 nM). GRI918013 can be used in research on cancer invasion and metastasis, such as melanoma, and can also serve as a tool compound for ATX-LPA axis-related diseases such as fibrotic diseases, neuropathic pain, and cholestatic pruritus .

Cat. No.	상품명	Target	Research Area

HY-P11444A

CD9-binding peptide TFA	Peptides	Cancer
CD9-binding peptide TFA is a CD9-binding peptide. CD9-binding peptide TFA inhibits the binding of EWI-2 to CD9. CD9-binding peptide TFA exhibits selective anti-migratory and anti-invasive activities against cancer cells. CD9-binding peptide TFA can be used for the study of cancer .

HY-P11444

CD9-binding peptide	Peptides	Cancer
CD9-binding peptide is a CD9-binding peptide. CD9-binding peptide inhibits the binding of EWI-2 to CD9. CD9-binding peptide exhibits selective anti-migratory and anti-invasive activities against cancer cells. CD9-binding peptide can be used for the study of cancer .

Cat. No.	상품명	Category	Target	Chemical Structure