BAS00602705

Cat. No.: HY-178521 Purity: 98.96%: Data Sheet
COA

SDS
Handling Instructions
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BAS00602705 is an E-cadherin inhibitor. BAS00602705 exerts its function by blocking the trans-interactions of E-cadherin molecules within junctional complexes, without permanently altering E-cadherin expression levels. BAS00602705 significantly impairs invadopodia formation in pancreatic cancer cells. BAS00602705 can be used for the study of anti-invasive therapeutic strategies in cancers characterized by dysregulated E-cadherin-mediated invadopodia activity, such as pancreatic ductal adenocarcinoma (PDAC).

For research use only. We do not sell to patients.

BAS00602705 Chemical Structure

CAS No. : 317321-89-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

492.36

Formula

C₂₅H₂₂BrN₃O₃

CAS No.

317321-89-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(CC1=CNC2=C1C=CC=C2)C(NC3=CC=C(C=C3)Br)=O)OCC4=CC=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (203.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0310 mL	10.1552 mL	20.3103 mL
5 mM	0.4062 mL	2.0310 mL	4.0621 mL
10 mM	0.2031 mL	1.0155 mL	2.0310 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.96%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) HNMR (283 KB) LCMS (335 KB)

Handling Instructions (2659 KB)

References

[1]. Dobric A, et al. E-Cadherin Is a Structuring Component of Invadopodia in Pancreatic Cancer. J Cell Mol Med. 2025 May;29(9):e70608. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0310 mL	10.1552 mL	20.3103 mL	50.7759 mL
	5 mM	0.4062 mL	2.0310 mL	4.0621 mL	10.1552 mL
	10 mM	0.2031 mL	1.0155 mL	2.0310 mL	5.0776 mL
	15 mM	0.1354 mL	0.6770 mL	1.3540 mL	3.3851 mL
	20 mM	0.1016 mL	0.5078 mL	1.0155 mL	2.5388 mL
	25 mM	0.0812 mL	0.4062 mL	0.8124 mL	2.0310 mL
	30 mM	0.0677 mL	0.3385 mL	0.6770 mL	1.6925 mL
	40 mM	0.0508 mL	0.2539 mL	0.5078 mL	1.2694 mL
	50 mM	0.0406 mL	0.2031 mL	0.4062 mL	1.0155 mL
	60 mM	0.0339 mL	0.1693 mL	0.3385 mL	0.8463 mL
	80 mM	0.0254 mL	0.1269 mL	0.2539 mL	0.6347 mL
	100 mM	0.0203 mL	0.1016 mL	0.2031 mL	0.5078 mL

BAS00602705 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAS00602705317321-89-4BAS 00602705BAS-00602705Cadherinpancreatic cancer cellspancreatic ductal adenocarcinomaE-cadherinInhibitorinhibitorinhibit

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BAS00602705

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