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antihepatotoxic

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By Targets:	Aldehyde Dehydrogenase (ALDH) (1) Amino Acid Derivatives (3) Bacterial (1) COX (1) Drug Derivative (1) Endogenous Metabolite (1) HDAC (1) Isotope-Labeled Compounds (1) Reference Standards (1) Tyrosinase (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (4) Inflammation/Immunology (2) Metabolic Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126052

Gnetol	COX Tyrosinase HDAC	Metabolic Disease Cancer
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-B1169

Timonacic 1 Publications Verification 1,3-Thiazolidine-4-carboxylic acid	Amino Acid Derivatives	Cardiovascular Disease Cancer
Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD₅₀ of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .

HY-N6911A

18α-Glycyrrhizic acid	Others	Inflammation/Immunology
18α-Glycyrrhizic acid is a derivate of Glycyrrhizic acid. 18α-Glycyrrhizic acid has weak antihepatotoxic anti-inflammatory activities .

HY-135627

JBP485 cyclo(L-Hyp-L-Ser)	Endogenous Metabolite	Others
JBP485 (cyclo-trans-4-L-hydroxyprolyl-L-serine) is a dipeptide with anti-hepatotoxic and wound healing properties. JBP485 can be used for research of various kinds of corneal epithelial diseases .

HY-B1169R

Timonacic (Standard) 1,3-Thiazolidine-4-carboxylic acid (Standard)	Amino Acid Derivatives Reference Standards	Cardiovascular Disease Cancer
Timonacic (Standard) is the analytical standard of Timonacic. This product is intended for research and analytical applications. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer .

HY-N2867

Andrographiside	Bacterial	Cancer
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

HY-N15464

Antihepatotoxic agent-1	Aldehyde Dehydrogenase (ALDH)	Metabolic Disease
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

HY-137962

Clanobutin	Drug Derivative	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Clanobutin is an orally active pharmaceutically acceptable N-acylanilinobutyric acid compound. Clanobutin increases gastrointestinal enzyme secretion. Clanobutin tonicizes the cardiovascular system, increases internal organ blood circulation, and boosts heart force. Clanobutin suppresses stomach ulcer formation and exhibits anti-hepatotoxic activity .

HY-W722107

Timonacic-d4 1,3-Thiazolidine-4-carboxylic acid-d₄	Isotope-Labeled Compounds Amino Acid Derivatives	Cardiovascular Disease Cancer
Timonacic-d₄ (1,3-Thiazolidine-4-carboxylic acid-d₄) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126052

Gnetol	Stilbenes Classification of Application Fields Phenols Polyphenols Gnetaceae Metabolic Disease Plants Disease Research Fields Gnetum montanum Markgr. Source Classification	COX Tyrosinase HDAC
Gnetol is a phenolic compound isolated from the root of Gnetum montanum . Gnetol potently inhibits COX-1 (IC₅₀ of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC₅₀ of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities .

HY-N6911A

18α-Glycyrrhizic acid	Glycyrrhiza glabra Linn. Leguminosae Ketones, Aldehydes, Acids Plants Source Classification	Others
18α-Glycyrrhizic acid is a derivate of Glycyrrhizic acid. 18α-Glycyrrhizic acid has weak antihepatotoxic anti-inflammatory activities .

HY-N2867

Andrographiside	Structural Classification Acanthaceae Simsia foetida (Cav.) S.F.Blake Terpenoids Diterpenoids Plants Source Classification	Bacterial
Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP) . Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins .

HY-N15464

Antihepatotoxic agent-1	Structural Classification Solanaceae Plants Lycium chinense Miller Saccharides Monosaccharides Source Classification	Aldehyde Dehydrogenase (ALDH)
Antihepatotoxic agent-1 is a cerebroside present in Lycium chinense Fruits with antihepatotoxic activity. Antihepatotoxic agent-1 exerts a protective effect by blocking the release of alanine aminotransferase and sorbitol dehydrogenase from primary cultured rat hepatocytes intoxicated with carbon tetrachloride. Antihepatotoxic agent-1 can be used in studies related to liver injury .

Cat. No.	Product Name	Chemical Structure

HY-W722107

Timonacic-d4
Timonacic-d₄ (1,3-Thiazolidine-4-carboxylic acid-d₄) is deuterium labeled Timonacic. Timonacic (1,3-Thiazolidine-4-carboxylic acid) is a thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects, and it can be used to study acute illnesses and liver diseases, by inducing reversal, it is also used in research on certain cancer cases .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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antihepatotoxic

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products