Search Result

Results for "

arthritic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (1) Apoptosis (4) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (1) Bombesin Receptor (2) Carbonic Anhydrase (1) CCR (2) COX (7) CXCR (3) DNA/RNA Synthesis (1) ERK (9) Fungal (4) HDAC (1) HMG-CoA Reductase (HMGCR) (1) Isotope-Labeled Compounds (2) JAK (3) Lipoxygenase (1) Melanocortin Receptor (6) mGluR (1) NF-κB (7) p38 MAPK (4) PGE synthase (1) Phosphodiesterase (PDE) (2) PI3K (1) Reactive Oxygen Species (ROS) (3) Reference Standards (9) RUNX (2) STAT (3) TNF Receptor (2) Wnt (2) Xanthine Oxidase (2) β-catenin (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (47) Metabolic Disease (3) Neurological Disease (8)

By Targets:

AMPK (1)

Apoptosis (4)

Autophagy (1)

Bacterial (4)

Biochemical Assay Reagents (1)

Bombesin Receptor (2)

Carbonic Anhydrase (1)

CCR (2)

COX (7)

CXCR (3)

DNA/RNA Synthesis (1)

ERK (9)

Fungal (4)

HDAC (1)

HMG-CoA Reductase (HMGCR) (1)

Isotope-Labeled Compounds (2)

JAK (3)

Lipoxygenase (1)

Melanocortin Receptor (6)

mGluR (1)

NF-κB (7)

p38 MAPK (4)

PGE synthase (1)

Phosphodiesterase (PDE) (2)

PI3K (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (9)

RUNX (2)

STAT (3)

TNF Receptor (2)

Wnt (2)

Xanthine Oxidase (2)

β-catenin (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (1)

Infection (6)

Inflammation/Immunology (47)

Metabolic Disease (3)

Neurological Disease (8)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108065A

3'-Sialyllactose sodium 1 Publications Verification 3'-SL sodium	NF-κB	Inflammation/Immunology
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-B1456A

Fenoprofen 2 Publications Verification LILLY-53858	COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-N2513

β-Boswellic acid 2 Publications Verification	Lipoxygenase DNA/RNA Synthesis	Cancer
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-N6647

Luteolin-7-rutinoside 1 Publications Verification	Fungal	Infection Inflammation/Immunology
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

HY-N4136

Lonicerin 1 Publications Verification Veronicastroside	Bacterial Apoptosis Xanthine Oxidase Fungal	Infection Neurological Disease Inflammation/Immunology
Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC₅₀ of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification	Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-111149A

PS372424 hydrochloride 2 Publications Verification	CXCR	Inflammation/Immunology
PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-N0705

Curculigoside Maximum Cited Publications 9 Publications Verification	JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108065

3'-Sialyllactose 3'-SL	NF-κB	Inflammation/Immunology
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-N2923

β-Amyrin acetate	HMG-CoA Reductase (HMGCR) Fungal	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-12511

SKF-86002 3 Publications Verification	p38 MAPK	Inflammation/Immunology
SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-N5010

Nepitrin Nepetin-7-glucoside	Others	Inflammation/Immunology
Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-P0107A

RC-3095 TFA 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-B0288B

Fenoprofen Calcium hydrate 2 Publications Verification LILLY-53858 Calcium hydrate	COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen (LILLY-53858) Calcium hydrate is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium hydrate is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium hydrate also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium hydrate has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-P0107

RC-3095 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-136540

Resolvin D3 RvD3	AMPK Autophagy	Inflammation/Immunology
Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-111149

PS372424	CXCR	Inflammation/Immunology
PS372424, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 prevents human T-cell migration in a humanized model of arthritic inflammation .

HY-B0288A

Fenoprofen Calcium LILLY-53858 Calcium	COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen (LILLY-53858) Calcium is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen Calcium is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen Calcium also increases ERK1/2 activation in HEK293T cells. Fenoprofen Calcium has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-145491

Resolvin D5	ERK NF-κB CCR	Inflammation/Immunology
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .

HY-107360

Lobenzarit disodium CCA	Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lobenzarit disodium (CCA) is an anti-arthritic and anti-oxidative agent .

HY-120529

Aciculatin	Biochemical Assay Reagents	Others
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

HY-18759

BMS-751324	p38 MAPK TNF Receptor	Inflammation/Immunology
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA). BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model .

HY-107510

YM-230888	mGluR	Neurological Disease
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a K_i of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models .

HY-100142

Clozic ICI 55897; Clobuzarit	Phosphodiesterase (PDE)	Inflammation/Immunology
Clozic is a potential anti-arthritic agent.

HY-120677

AHR-15010	Carbonic Anhydrase	Inflammation/Immunology
AHR-15010 is an oral active carbonic anhydrase inhibitor with the IC₅₀ of 0.13 μM. AHR-15010 shows anti-arthritic activity and can be used for study of arthritis .

HY-N5010R

Nepitrin (Standard) Nepetin-7-glucoside (Standard)	Reference Standards Others	Inflammation/Immunology
Nepitrin (Standard) is the analytical standard of Nepitrin. This product is intended for research and analytical applications. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-P10850

PIYLGGVFQ	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
PIYLGGVFQ is a peptide inhibitor for TNF-α. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritic activity in the CIA mouse model .

HY-Y0585R

D-(-)-Mandelic acid (Standard)	Reference Standards Bacterial	Infection Inflammation/Immunology
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-136540S

Resolvin D3-d5 RvD3-d₅	Isotope-Labeled Compounds	Inflammation/Immunology
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-N8458

Cryogenine NSC 272693	PGE synthase	Inflammation/Immunology
Cryogenine is an alkaloid originally isolated from H. salicifolia that has anti-inflammatory activity. It inhibits prostaglandin synthetase (IC₅₀=424 μM). Cryogenine (100 mg/kg per day, p.o.) reduces paw edema and the mean arthritic index in a rat model of adjuvant-induced polyarthritis.

HY-N0705R

Curculigoside (Standard)	Reference Standards JAK STAT NF-κB	Neurological Disease Inflammation/Immunology Cancer
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108641

SKF-86002 dihydrochloride	p38 MAPK	Inflammation/Immunology
SKF-86002 dihydrochloride is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC₅₀ = 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-108065AR

3'-Sialyllactose sodium (Standard) 3'-SL sodium (Standard)	NF-κB Reference Standards	Inflammation/Immunology
3'-Sialyllactose (sodium) (Standard) is the analytical standard of 3'-Sialyllactose (sodium). This product is intended for research and analytical applications. 3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-129566R

Withanolide B (Standard)	Reference Standards ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N4136R

Lonicerin (Standard) Veronicastroside (Standard)	Reference Standards Bacterial Apoptosis Xanthine Oxidase Fungal	Infection Neurological Disease Inflammation/Immunology
Lonicerin (Standard) (Veronicastroside (Standard)) is the analytical standard of Lonicerin (HY-N4136). This product is intended for research and analytical applications. Lonicerin is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC₅₀ of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.

HY-12511R

SKF-86002 (Standard)	p38 MAPK	Inflammation/Immunology
SKF-86002 (Standard) is the analytical standard of SKF-86002. This product is intended for research and analytical applications. SKF-86002 is an orally active p38 MAPK inhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 inhibits lipopolysaccharide (LPS)-stimulate human monocyte IL-1 and TNF-α production (IC50 = 1 μM). SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid .

HY-B1456AR

Fenoprofen (Standard) LILLY-53858 (Standard)	Reference Standards COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen (Standard) (LILLY-53858 (Standard)) is the analytical standard of Fenoprofen (HY-B1456A). This product is intended for research and analytical applications. Fenoprofenc is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.

HY-163368

HDAC6-IN-34	HDAC	Inflammation/Immunology
HDAC6-IN-34 (compound 21) is an oral active and selective HDAC6 inhibitor with the IC₅₀ of 18 nM. HDAC6-IN-34 increases the acetylation level of tubulin without affecting histone acetylation in cutaneous T-cell lymphoma cells and inhibits TNF-α secretion in LPS (HY-D1056)-stimulated macrophage cells. HDAC6-IN-34 shows excellent anti-arthritic efficacy in rat .

HY-115913

PDE4-IN-6	Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-6 is a potent, safe and moderately selective PDE4 inhibitor with IC₅₀s of 0.125 and 0.43 µM for PDE4B and PDE4D, respectively. PDE4-IN-6 can downregulate the expression level of TNF-α and IL-6. PDE4-IN-6 has potent immunomodulatory activity thereby its potential against rheumatoid arthritis. Anti-inflammatory and anti-arthritic effects .

HY-B0288BR

Fenoprofen Calcium hydrate (Standard) LILLY-53858 Calcium hydrate (Standard)	Reference Standards COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen (LILLY-53858 (Standard)) (Standard) Calcium hydrate is the analytical standard of Fenoprofen Calcium hydrate (HY-B0288B). This product is intended for research and analytical applications. Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.

HY-B1456AS

Fenoprofen-13C6 sodium hydrate LILLY-53858-13C6 sodium hydrate	Isotope-Labeled Compounds COX Melanocortin Receptor ERK	Inflammation/Immunology
Fenoprofen- ¹³C₆ (LILLY-53858- ¹³C₆) sodium hydrate is the ¹³C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

HY-N16465

Cinnamtannin D1	Apoptosis Reactive Oxygen Species (ROS) STAT	Inflammation/Immunology
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) .

HY-177277

HM5023507	PI3K	Inflammation/Immunology
HM5023507 is an orally active and selective PI3Kδ/γ inhibitor with IC₅₀s of 4  and 5  μM for PI3Kδ and PI3Kγ over PI3Kβ and PI3Kα. HM5023507 attenuates the PI3Kδ/γ signaling in human basophils. HM5023507 also attenuates the activation and function of human B and T cells and cytokine and IgG production during cocultures, and Th17 differentiation of CD4 T cells. HM5023507 inhibited semiestablished collagen-induced arthritic inflammation in the rat models. HM5023507 can be used for inflammatory diseases like rheumatoid arthritis research .

HY-105628

Prodilidine CI-427	Others	Neurological Disease Inflammation/Immunology
Prodilidine (CI-427) is an orally active, pyrrolidine-derived non-narcotic pain inhibitor. Prodilidine exerts analgesic activity against various nociceptive stimuli, and shows no antipyretic, anti-inflammatory or respiratory depressive effects. Prodilidine fails to inhibit withdrawal symptoms of addictive agents in monkeys, but exhibits excitatory effects and enhances the crossed extensor reflex at toxic doses. Prodilidine is well absorbed from the gastrointestinal tract and metabolized via hepatic microsomal N-demethylation, displaying isomer-specific activity, toxicity and metabolic characteristics. Prodilidine can be used in research related to chronic pain (e.g., cancer-, musculoskeletal/arthritis-derived), traumatic pain and arthritic pain .

HY-183868

Dimefadane hydrochloride	COX	Inflammation/Immunology
Dimefadane hydrochloride is a non-steroidal anti-inflammatory drug (NSAID) and anti-arthritic agent. Dimefadane hydrochloride can be used in arthritis-related research .

HY-107360R

Lobenzarit disodium (Standard) CCA (Standard)	Reference Standards Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lobenzarit disodium (Standard) (CCA (Standard)) is the analytical standard of Lobenzarit (disodium) (HY-107360). This product is intended for research and analytical applications. Lobenzarit disodium (CCA) is an anti-arthritic and anti-oxidative agent .

HY-164630

CCR5/CXCR3-IN-1	CCR CXCR	Inflammation/Immunology
CCR5/CXCR3-IN-1 (compound 1) is a CXCR3 and CCR5 inhibitor. CCR5/CXCR3-IN-1 inhibits chemotaxis of CXCR3 and CCR5-expressing transformed cells, and does not inhibits the chemotaxis of transfected cells expressing CXCR4. CCR5/CXCR3-IN-1 can be used for the study of chronic arthritic rheumatism .

HY-181929

RAI-20 H018	JAK	Inflammation/Immunology
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor (IC₅₀=15.1 and 22.7 nM). RAI-20 exhibits excellent pharmacokinetic properties, including plasma stability, systemic exposure, and a long half-life. In a collagen-induced arthritis rat model, RAI-20 shows significant anti-inflammatory and anti-arthritic activities, effectively reducing paw swelling volume and arthritis index. RAI-20 can be used for research on the pathogenesis of rheumatoid arthritis .

Cat. No.	Product Name	Target	Research Area

HY-P0107A

RC-3095 TFA 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 TFA is a selective bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 TFA exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-P0107

RC-3095 1 Publications Verification	Bombesin Receptor	Inflammation/Immunology
RC-3095 is a bombesin/gastrin releasing peptide receptor (GRPR) antagonist . RC-3095 exerts protective effects by reducing gastric oxidative injury in the arthritic mice .

HY-P10850

PIYLGGVFQ	TNF Receptor NF-κB Apoptosis	Inflammation/Immunology
PIYLGGVFQ is a peptide inhibitor for TNF-α. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritic activity in the CIA mouse model .

HY-P4096A

Cys-HAP-1	Peptides	Inflammation/Immunology
Cys-HAP-1 is a synovium-homing peptide that specifically binds to human and rabbit fibroblast-like synoviocytes, and does not bind to human umbilical vein endothelial cells regardless of TNF-α treatment. Cys-HAP-1 enables targeted drug delivery to inflamed joints after conjugation with liposomes loaded with anti-arthritic agents. Cys-HAP-1 can be used in studies related to adjuvant arthritis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-108065A

3'-Sialyllactose sodium 1 Publications Verification 3'-SL sodium	Polysaccharides Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Source Classification	NF-κB
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-N2513

β-Boswellic acid 2 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Boswellia serrata Plants Burseraceae Disease Research Fields Source Classification Cancer	Lipoxygenase DNA/RNA Synthesis
β-Boswellic acid is isolated from the gum resin of Boswellia serrata with anticancer, antioxidant activity, anti-inflammatory activity and anti-arthritic pain.β-Boswellic acid is an orally active nonreducing-type inhibitor of the 5-lipoxygenase (5-LO) product formation either interacting directly with the 5-LO or blocking its translocation. β-Boswellic acid inhibits the synthesis of DNA, RNA and protein in human leukemia HL-60 cells with IC₅₀ values ranging from 0.6 to 7.1 μM. β-Boswellic acid is promising for research of diabetes, inflammatory and arthritic diseases .

HY-N6647

Luteolin-7-rutinoside 1 Publications Verification	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Fungal
Luteolin-7-rutinoside has both anti-arthritic and antifungal activities, can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.

HY-N4136

Lonicerin 1 Publications Verification Veronicastroside	Infection Flavonoids Caprifoliaceae Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification	Bacterial Apoptosis Xanthine Oxidase Fungal
Lonicerin (Veronicastroside) is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC₅₀ of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties .

HY-Y0585

D-(-)-Mandelic acid 1 Publications Verification	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Rosaceae Other Diseases Armeniaca vulgaris Lam. Plants Endogenous metabolite Disease Research Fields Source Classification	Bacterial
D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-129566

Withanolide B	Neurological Disease Classification of Application Fields Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids Source Classification	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0705

Curculigoside Maximum Cited Publications 9 Publications Verification	Curculigo orchioides Gaertn. Monophenols Neurological Disease Classification of Application Fields Phenols Plants Amaryllidaceae Disease Research Fields Source Classification Cancer	JAK STAT NF-κB
Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108065

3'-Sialyllactose 3'-SL	Natural Products Classification of Application Fields Animals Inflammation/Immunology Disease Research Fields	NF-κB
3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-N2923

β-Amyrin acetate	Triterpenes Ficus exasperata Vahl Plants Moraceae Source Classification	HMG-CoA Reductase (HMGCR) Fungal
β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase .

HY-N5010

Nepitrin Nepetin-7-glucoside	Flavonoids Classification of Application Fields Flavones Labiatae Cassia Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Source Classification	Others
Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-145491

Resolvin D5	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	ERK NF-κB CCR
Resolvin D5 is an anti-inflammatory and analgesic agent produced in M2 macrophages. Resolvin D5 alleviates Paclitaxel (HY-B0015)-induced mechanical allodynia and inflammatory pain by activating the GPR32 receptor, with gender specificity (effective only in male mice) and independence from TRPV1 or TRPA1 channels. Resolvin D5 attenuates LPS-induced ERK phosphorylation and NF-κB nuclear translocation, downregulates proinflammatory mediators such as IL-6 and CCL5, inhibits Th17 cell differentiation and osteoclastogenesis, promotes regulatory T cell differentiation, and shows no cytotoxicity to human monocytes. The level of Resolvin D5 is elevated in arthritic SKG mice, but Resolvin D5 has no effect on dendritic cell differentiation or M1 macrophage polarization, nor does it prevent ZyA-induced arthritis progression. Resolvin D5 is suitable for research related to chemotherapy-induced peripheral neuropathy, inflammatory pain and rheumatoid arthritis .

HY-120529

Aciculatin	Flavonoids Flavones Gramineae Plants Themeda arguens (L.) Hack. Source Classification	Biochemical Assay Reagents
Aciculatin is a compound with cytotoxic, anti-inflammatory and anti-arthritic activities, and its synthetic route including specific chemical reaction steps was determined through the first total synthesis.

HY-N5010R

Nepitrin (Standard) Nepetin-7-glucoside (Standard)	Structural Classification Flavonoids Flavones Labiatae Cassia Phenols Polyphenols Plants Source Classification	Reference Standards Others
Nepitrin (Standard) is the analytical standard of Nepitrin. This product is intended for research and analytical applications. Nepitrin, isolated from Scrophularia striata, possess significant anti-inflammatory and anti-arthritic activity .

HY-Y0585R

D-(-)-Mandelic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Rosaceae Armeniaca vulgaris Lam. Plants Endogenous metabolite Source Classification	Reference Standards Bacterial
D-(-)-Mandelic acid (Standard) is the analytical standard of D-(-)-Mandelic acid. This product is intended for research and analytical applications. D-(-)-Mandelic acid is an orally active alpha hydroxycarboxylic acid that can be isolated from bitter almonds and Indian chestnut trees. It has antioxidant and antibacterial properties and is expected to play an important role in the treatment of rheumatoid arthritis .

HY-N0705R

Curculigoside (Standard)	Curculigo orchioides Gaertn. Structural Classification Monophenols Phenols Plants Amaryllidaceae Source Classification	Reference Standards JAK STAT NF-κB
Curculigoside (Standard) is the analytical standard of Curculigoside. This product is intended for research and analytical applications. Curculigoside is the main saponin in C. orchioide, exerts significant antioxidant, anti-osteoporosis, antidepressant and neuroprotection effects. Curculigoside possesses significant anti-arthritic effects in vivo and in vitro via regulation of the JAK/STAT/NF-κB signaling pathway .

HY-108065AR

3'-Sialyllactose sodium (Standard) 3'-SL sodium (Standard)	Structural Classification Polysaccharides Animals Saccharides Source Classification	NF-κB Reference Standards
3'-Sialyllactose (sodium) (Standard) is the analytical standard of 3'-Sialyllactose (sodium). This product is intended for research and analytical applications. 3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation .

HY-129566R

Withanolide B (Standard)	Withania somnifera Solanaceae Plants Steroids Source Classification	Reference Standards ERK Wnt β-catenin RUNX
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N4136R

Lonicerin (Standard) Veronicastroside (Standard)	Structural Classification Flavonoids Caprifoliaceae Flavones Phenols Polyphenols Plants Source Classification	Reference Standards Bacterial Apoptosis Xanthine Oxidase Fungal
Lonicerin (Standard) (Veronicastroside (Standard)) is the analytical standard of Lonicerin (HY-N4136). This product is intended for research and analytical applications. Lonicerin is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC₅₀ of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.

HY-N16465

Cinnamtannin D1	Phenols Polyphenols Plants Lauraceae Lindera glauca (Siebold & Zucc.) Blume Source Classification	Apoptosis Reactive Oxygen Species (ROS) STAT
Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA) .

Cat. No.	Product Name	Chemical Structure

HY-136540S

Resolvin D3-d5
Resolvin D3-d₅ is the deuterium labeled Resolvin D3. Resolvin D3 (RvD3) is a docosahexaenoic acid (DHA) derived mediator. Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation .

HY-B1456AS

Fenoprofen-13C6 sodium hydrate

Fenoprofen- ¹³C₆ (LILLY-53858- ¹³C₆) sodium hydrate is the ¹³C labeled Fenoprofen (HY-B1456A).Fenoprofen (LILLY-53858) is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

arthritic

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products