aspartate aminotransferase

By Targets:	Aminotransferases (Transaminases) (10) Apoptosis (1) Biochemical Assay Reagents (3) COX (1) Cytochrome P450 (3) Endogenous Metabolite (2) Environmental Pollutants (2) ERK (2) HBV (1) HSP (1) IKK (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JNK (1) Monoamine Oxidase (2) NF-κB (3) NO Synthase (2) p38 MAPK (2) Phosphatase (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) STAT (1) TNF Receptor (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (4) Endocrinology (2) Infection (1) Inflammation/Immunology (4) Metabolic Disease (6) Neurological Disease (3)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Solvents (1)

Targets Recommended: Branched Chain Amino Acid Transaminase (BCAT)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-154629

Sesame Oil 2 Publications Verification	Environmental Pollutants Biochemical Assay Reagents Interleukin Related NO Synthase Aminotransferases (Transaminases) NF-κB	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, **aspartate aminotransferase*, alanine aminotransferase, IL-1β, IL-4* and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .

HY-P3016A

Aspartate aminotransferase, porcine heart EC 2.6.1.1, porcine heart; GOT, porcine heart; AST, porcine heart	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), porcine heart is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, porcine heart comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, porcine heart also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, porcine heart is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-P3016

Aspartate aminotransferase, Genetically engineered bacteria EC 2.6.1.1; GOT; AST	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Genetically engineered bacteria is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Genetically engineered bacteria comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Genetically engineered bacteria also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Genetically engineered bacteria is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-N5092

7-Methylcoumarin	Reactive Oxygen Species (ROS) Cytochrome P450	Metabolic Disease
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-Y0284

Diethyl phthalate 2 Publications Verification	Environmental Pollutants Biochemical Assay Reagents Apoptosis Aminotransferases (Transaminases) Phosphatase	Endocrinology
Diethyl phthalate is an orally active plasticizer and detergent base. Diethyl phthalate increases the activities of ACP, ALP, SDH, and ALT in liver, muscle, or both tissues. Diethyl phthalate induces dose-dependent mortality and sluggish behavior in freshwater fish. Diethyl phthalate may induce male reproductive toxicity. Diethyl phthalate is added to plastic polymers to help maintain their flexibility .

HY-124825

iGOT1-01	Aminotransferases (Transaminases)	Cancer
iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC₅₀s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity .

HY-N0854

Alisol F 1 Publications Verification	HBV ERK JNK p38 MAPK STAT NF-κB TNF Receptor Interleukin Related NO Synthase COX	Metabolic Disease Cancer
Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage .

HY-P3016B

Aspartate aminotransferase, Human liver EC 2.6.1.1, Human liver; GOT, Human liver; AST, Human liver	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Human liver is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human liver comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human liver also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human liver is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-176192

SMU-14a	Toll-like Receptor (TLR) NF-κB p38 MAPK ERK IKK TNF Receptor Interleukin Related	Inflammation/Immunology
SMU-14a is a selective Toll-like receptor 3 (TLR3) inhibitor wirh an IC₅₀ of 0.18 μM. SMU-14a reduces phosphorylation of p65, ERK, and TBK1 via NF-κB, MAPK, and IRF3 signaling pathways. SMU-14a inhibits IL-6 secretion in mouse peritoneal macrophages, downregulates TNF-α in human peripheral blood monocytes and decreases serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. SMU-14a can be used for the research of acute hepatitis .

HY-131921

DL-Glyceraldehyde 3-phosphate diethyl acetal barium	Biochemical Assay Reagents	Endocrinology
DL-Glyceraldehyde 3-phosphate diethyl acetal barium is an **Aspartate Aminotransferase** isozyme inhibitor .

HY-E70327

Aspartate Aminotransferase, Human	Endogenous Metabolite	Others
Aspartate Aminotransferase, Human is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .

HY-P2891A

Pyruvate oxidase, Aerococcus viridans PoxB, Aerococcus viridans	Endogenous Metabolite	Others
Pyruvate oxidase, Aerococcus viridans (PoxB) is a thiamine pyrophosphate-dependent oxidase that catalyzes the oxidative decarboxylation of pyruvate to produce acetyl phosphate, carbon dioxide, and water. Pyruvate oxidase, Aerococcus viridans is an important enzyme in bacterial metabolism and can enhance ATP production. Additionally, Pyruvate oxidase, Aerococcus viridans can be used for the determination of aspartate aminotransferase and alanine aminotransferase activities .

HY-P1887

p5 Ligand for Dnak and DnaJ	HSP	Infection
p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ .

HY-N15587

Gostatin Gostatine	Aminotransferases (Transaminases)	Metabolic Disease
Gostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism .

HY-N5092R

7-Methylcoumarin (Standard)	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450	Metabolic Disease
7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-W008440S

DL-Cycloserine-15N,d3	Isotope-Labeled Compounds Aminotransferases (Transaminases) Monoamine Oxidase	Neurological Disease Inflammation/Immunology
DL-Cycloserine- ¹⁵N,d₃ is the deuterium labeled DL-Cycloserine (HY-W008440). DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

HY-P3016C

Aspartate aminotransferase, Human (HEK293) EC 2.6.1.1, Human (HEK293); GOT, Human (HEK293); AST, Human (HEK293)	Aminotransferases (Transaminases)	Cardiovascular Disease
Aspartate aminotransferase (EC 2.6.1.1), Human (HEK293) is a metabolic regulator with the highest activity in the heart, liver and skeletal muscle. Aspartate aminotransferase, Human (HEK293) comprises two isozymes: the cytoplasmic form (AST1) and the mitochondrial form (AST2). By catalyzing reversible transamination reactions between oxaloacetate, L-glutamate and other substances, it is deeply involved in key physiological processes such as amino acid metabolism, the tricarboxylic acid cycle and neurotransmitter synthesis. Aspartate aminotransferase, Human (HEK293) also provides substrate support for the synthesis of urea and purines/pyrimidines. Aspartate aminotransferase, Human (HEK293) is a serum marker reflecting cardiac and hepatic injury, and its abnormal levels are also closely associated with myocardial infarction, cardiovascular diseases and various cancers .

HY-N17495

Luteolin 7-O-(6-O-malonyl-β-D-glucoside)	Others	Metabolic Disease
Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is an orally active flavonoid free radical scavenger. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) scavenges free radicals, inhibits the activity elevation of aspartate aminotransferase and alanine aminotransferase in mouse plasma, as well as the elevation of liver lipid hydroperoxide content. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is applicable for liver injury research .

HY-W008440

DL-Cycloserine	Aminotransferases (Transaminases) Monoamine Oxidase	Neurological Disease Inflammation/Immunology
DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

HY-119578

Imiprothrin	Cytochrome P450	Cancer
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

Cat. No.	Product Name	Type

HY-131921

DL-Glyceraldehyde 3-phosphate diethyl acetal barium	Biochemical Assay Reagents
DL-Glyceraldehyde 3-phosphate diethyl acetal barium is an **Aspartate Aminotransferase** isozyme inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P1887

p5 Ligand for Dnak and DnaJ	HSP	Infection
p5 Ligand for Dnak and DnaJ is a nonapeptide, which corresponds to the main binding site for the 23-residue part of the presequence of mitochondrial aspartate aminotransferase. p5 Ligand for Dnak and DnaJ is a high-affinity ligand for DnaK and DnaJ .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5092

7-Methylcoumarin	Microorganisms Coumarins Metabolic Disease Phenylpropanoids Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Cytochrome P450
7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-N0854

Alisol F 1 Publications Verification	Infection Triterpenes Structural Classification Classification of Application Fields Terpenoids Alisma orinentale (Samuel.) Juz. Alismataceae Plants Disease Research Fields Source Classification	HBV ERK JNK p38 MAPK STAT NF-κB TNF Receptor Interleukin Related NO Synthase COX
Alisol F is a protostane-type triterpenoid with anti-inflammatory and anti-hepatitis B virus activities. Alisol F inhibits LPS (HY-D1056)-induced phosphorylation of ERK, JNK, p38, STAT3 and NF-κB (p65), suppresses the production of NO, IL-6, TNF-α and IL-1β, and also downregulates the levels of iNOS and COX-2. Alisol F reduces the serum alanine aminotransferase and aspartate aminotransferase levels in mice with acute liver injury and ameliorates their liver pathological damage .

HY-N15587

Gostatin Gostatine	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Aminotransferases (Transaminases)
Gostatin is an inhibitor of aspartate aminotransferase (GOT). Gostatin is found in Streptomyces sumanensis nov. sp. NK-23. Gostatin has a strong inhibitory effect on pig heart GOT, a weak inhibitory effect on wheat germ GOT and GPT, and no significant effect on glutamate dehydrogenase and glutamine synthetase. The inhibitory mechanism of gostatin is similar to substrate competitive inhibition, and aspartate has a protective effect on its inhibitory effect. Gostatin can be used to study the catalytic mechanism of GOT and its role in nitrogen metabolism .

HY-N5092R

7-Methylcoumarin (Standard)	Microorganisms Coumarins Phenylpropanoids Source Classification	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450
7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl₄-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .

HY-N17495

Luteolin 7-O-(6-O-malonyl-β-D-glucoside)	Structural Classification Flavonoids Dendranthema morifolium (Ramat.) Tzvel. Plants Compositae Other Flavonoids Source Classification	Others
Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is an orally active flavonoid free radical scavenger. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) scavenges free radicals, inhibits the activity elevation of aspartate aminotransferase and alanine aminotransferase in mouse plasma, as well as the elevation of liver lipid hydroperoxide content. Luteolin 7-O-(6-O-malonyl-β-D-glucoside) is applicable for liver injury research .

Cat. No.	Product Name	Chemical Structure

HY-W008440S

DL-Cycloserine-15N,d3
DL-Cycloserine- ¹⁵N,d₃ is the deuterium labeled DL-Cycloserine (HY-W008440). DL-Cycloserine is an orally active aminotransferase inhibitor. DL-Cycloserine exhibits completely opposite effects on the activity of monoamine oxidase in different tissues. DL-Cycloserine can be used for the research of pulmonary tuberculosis, psychosomatic diseases, and depressive states .

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (3) Rat (2) Mouse (3)
Application:	IHC-P (2) ICC/IF (2) IHC-F (2) WB (3)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82430

	Aspartate Aminotransferase Antibody (YA2175) aspartate aminotransferase; cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Aspartate Aminotransferase Antibody (YA2175) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aspartate Aminotransferase.

HY-P82430A

	Aspartate Aminotransferase Antibody (YA2175)(PBS only) aspartate aminotransferase; cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
	Aspartate Aminotransferase Antibody (YA2175) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Aspartate Aminotransferase.

HY-P85630

	GOT2 Antibody (YA5322) AATM_HUMAN; AL022787; aspartate aminotransferase; aspartate aminotransferase 2; aspartate aminotransferase, mitochondrial; ASPATA; FABP 1; FABP pm; FABP-1; FABPpm; Fatty acid binding protein; Fatty acid-binding protein; FLJ40994; Glutamate oxaloacetate transaminase 2; Glutamate oxaloacetate transaminase 2, mitochondrial; Glutamate oxaloacetate transaminase, mitochondrial; Glutamic oxaloacetic transaminase 2, mitochondrial; aspartate aminotransferase 2; Got 2; GOT2; KAT4; KATIV; Kynurenine aminotransferase IV; mAspAT; MGC102129; MGC115763; mitAAT; mitochondrial; Mitochondrial aspartate aminotransferase; OTTMUSP00000017748; Plasma membrane fatty acid binding protein; Plasma membrane-associated fatty acid-binding protein; Transaminase A.	WB	Human, Mouse
	GOT2 Antibody (YA5322) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GOT2.

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Cat. No.	Product Name		Classification

HY-119578

Imiprothrin		Alkynes
Imiprothrin is an inducer that induces CYP1A2 and metallothionein 1a, with significant genotoxicity and cytotoxicity. In rat hepatocytes, Imiprothrin initiates detoxification responses by triggering the overexpression of these two genes. Imiprothrin induces chromosomal aberrations and micronucleus formation in rat bone marrow cells, and causes DNA damage in hepatocytes. Imiprothrin triggers oxidative stress in rats, leading to lipid peroxidation, excessive reactive oxygen species production and redox imbalance, which in turn impairs liver and kidney functions and causes tissue damage. Imiprothrin inhibits weight gain in mice, and even causes high mortality in female mice at high doses. However, it shows no carcinogenicity in rat experiments; among relevant indicators, aspartate aminotransferase and total protein are identified as sensitive toxicity biomarkers .

Cat. No.	Product Name		Classification

HY-154629

Sesame Oil 2 Publications Verification		Solvents
Sesame Oil is a vegetable oil. Sesame Oil can be extracted from the seeds of Sesamum indicum L. Sesame Oil decreases NF-κB, **aspartate aminotransferase*, alanine aminotransferase, IL-1β, IL-4* and nitric oxide. Sesame Oil has antitumor activity against malignant melanoma. Sesame Oil has protective effects against liver damage caused by various agents such as Cisplatin (HY-17394) and Acetaminophen (HY-66005). Sesame Oil shows antinociceptive and anti-inflammatory activities .

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aspartate aminotransferase

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Biochemical Assay Reagents

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Isotope-Labeled Compounds

Antibodies

Click Chemistry

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