882256-55-5
882256-55-5
Chemical Structure
iGOT1-01
- No. CAS: 882256-55-5
- Formula:C19H20N4O
- Molecular Weight:320.39
IUPAC Name: 4-(1H-indol-4-yl)-N-phenylpiperazine-1-carboxamide
InChIKey: MGSDOEMLWKEWSV-UHFFFAOYSA-N
SMILES: O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=CC=C4
Biological Activity: iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity[1][2].
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iGOT1-01 | 99.18% | iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 μM and 11.3 μM in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.85
HY-122723GOT1 inhibitor-1 -
Similarity Score 0.69
HY-1095275-HT7 agonist 1 -
Similarity Score 0.67
HY-120021tert-Butyl 4-(1H-indol-4-yl)piperazine-1-carboxylate -
Similarity Score 0.63
HY-10867PF-622 -
Similarity Score 0.62
HY-339214-(1-Piperazinyl)-1H-Indole hydrochloride -
Similarity Score 0.57
HY-18081PF 750 -
Similarity Score 0.56
HY-127179ML189 -
Similarity Score 0.55
HY-19960RBCTC (Standard) -
Similarity Score 0.55
HY-165555MMV665917 -
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References
- [1]. Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. [Content Brief]
- [2]. Melissa C Holt, et al. Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. 2018 Nov 27;57(47):6604-6614. [Content Brief]
