1 Result for "

autonomous CaMKII

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "autonomous CaMKII" in MCE Product Catalog:

TAT-CN21
TAT-CN21
0 Images
Cat. No.: HY-P10638
Target:  

CaMK

Research Areas:  

Cardiovascular Disease Neurological Disease

TAT-CN21 is a potent CaMKII inhibitor with an IC50 of 77.2 nM. TAT-CN21 inhibits both calcium/calmodulin-dependent and autonomously activated CaMKII, blocks glutamate-induced translocation of CaMK IIα, and reverses the enhanced phosphorylation of CaMKII at Thr286 following excitotoxic injury. TAT-CN21 shows application potential in studies related to ischemic stroke by reducing neuronal excitotoxicity and exacerbating pre-existing long-term neuronal death prior to injury. TAT-CN21 improves definitive behaviors in rats with residual nerve injury without altering indicators such as mechanical/thermal hyperalgesia or spatial memory. TAT-CN21 can also be used in studies related to neuropathic pain .
loading...
    loading...
View All Sizes
Assay Types