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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
calmodulin-dependent Phosphodiesterase
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "calmodulin-dependent Phosphodiesterase" in MCE Product Catalog:
10
10 Cited Publications
Research Areas:
W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca 2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias .
10
10 Cited Publications
Cat. No.: HY-130368
CAS No.: 65595-90-6
Research Areas:
W-7 is a selective calmodulin antagonist. W-7 inhibits the Ca 2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 induces apoptosis and has antitumor and vascular relaxing activity. W-7 is a blocker of Kv4.3 and can be used for research of arrhythmias .
Target:
Research Areas:
Phenacaine (Holocaine) is a local agent that can suppress or relieve pain. Phenacaine inhibits the specific calmodulin-dependent stimulation of erythrocyte Ca 2+-ATPase and cyclic nucleotide phosphodiesterases from brain and heart .
Cat. No.: HY-120997
CAS No.: 114784-59-7
Synonyms: Berbamine p-nitrobenzoate
Target:
Research Areas:
E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia .
Cat. No.: HY-130748
CAS No.: 105114-22-5
Target:
Research Areas:
K-252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain (IC50=350 nM). It also inhibits calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart (IC50=46.2 μM).
Cat. No.: HY-P2209
CAS No.: 53947-96-9
Synonyms: Daechuine S27; N-Demethylamphibine H
Category:
Alkaloids Other Alkaloids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae
Target:
Cat. No.: HY-P74648
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: PDE1C; Phosphodiesterase 1C, calmodulin-dependent (70kD); Phosphodiesterase 1C; 3',5'-Cyclic-GMP Phosphodiesterase; Hcam3; 3',5'-Cyclic-AMP Phosphodiesterase; Dual Specificity Calcium/calmodulin-dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1C; Unch
Species:
Human
Source:
Sf9 insect cells
Target:
Research Areas:
Moxaverine hydrochloride is a phosphodiesterase (PDE) inhibitor. Moxaverine hydrochloride also interacts with calmodulin (calmodulin), thereby enhancing the inhibition of calmodulin-dependent PDE. Moxaverine hydrochloride can be used in studies related to microcirculation regulation and ocular tissue distribution .
Cat. No.: HY-114554
CAS No.: 103370-21-4
Category:
Target:
Cat. No.: HY-100912R
CAS No.: 61714-27-0
Research Areas:
W-7 (hydrochloride) (Standard) is the analytical standard of W-7 (hydrochloride) (HY-100912). This product is intended for research and analytical applications. W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor and vascular relaxing activity. W-7 hydrochloride is a blocker of Kv4.3 and can be used for research of arrhythmias .
Cat. No.: HY-P75960
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PDE1B; Calcium/calmodulin-dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B; Prev. PDES1B; Epididymis Secretory Sperm Binding Protein Li 79p; Dual Specificity Calcium/calmodulin-dependent 3',5'-Cyclic Nucleotide Phosphodiesterase 1B; calmodulin-Stimu
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
