2. Membrane Transporter/Ion Channel Cytoskeleton Metabolic Enzyme/Protease
  3. Calmodulin Myosin Phosphodiesterase (PDE)
  4. E6 Berbamine

E6 Berbamine  (Synonyms: Berbamine p-nitrobenzoate)

Cat. No.: HY-120997
Handling Instructions Technical Support

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia.

For research use only. We do not sell to patients.

E6 Berbamine

E6 Berbamine Chemical Structure

CAS No. : 114784-59-7

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E6 Berbamine Related Antibodies

Top Publications Citing Use of Products

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CALM1 CALM2 CALM3

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MLCK

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activities of calmodulin-dependent myosin light chain kinase (MLCK) and phosphodiesterase (PDE). E6 Berbamine exhibits anti-leukemic activity. E6 Berbamine can be used in research related to cardiovascular abnormalities and chronic myeloid leukemia[1][2].

Cellular Effect
Cell Line Type Value Description References
K562 IC50
2.13 μM
Compound: 3n
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
Cytotoxicity against human imatinib-resistant K562 leukemia cells expressing p210Bcr/Abl and MDR1 at 48 hrs by MTT assay
[PMID: 19285759]
In Vitro

E6 Berbamine (2 min) acts as a competitive calmodulin (CaM) antagonist, potently inhibiting CaM-activated myosin light chain kinase (MLCK) activity in chicken gastric tissues, with a Ki of 0.95 μM and an IC50 of 8 μM[1].
E6 Berbamine binds directly to dansyl-labeled porcine brain CaM bound to Ca2+, with a Ki of approximately 1 μM[1].
E6 Berbamine inhibits the activity of calmodulin-dependent phosphodiesterase with an IC50 of 0.53 μM[1].
E6 Berbamine (Compound 3n) inhibits the activity of K562 cells with an IC50 value of 2.13 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

E6 Berbamine Related Antibodies
Molecular Weight

757.83

Formula

C44H43N3O9
CAS No.
SMILES

COC1=C(OC2=CC3=C(C=C2OC)CCN4C)C5=C(C=C1OC)CCN(C)[C@@]5(CC6=CC=C(C(OC7=CC=C(C=C7)C[C@@]34[H])=C6)OC(C8=CC=C(C=C8)[N+]([O-])=O)=O)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E6 Berbamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E6 Berbamine114784-59-7Berbamine p-nitrobenzoateCalmodulinMyosinPhosphodiesterase (PDE)CaMCalcium-Modulated Proteinchicken MLCKCaM-dependent PDEporcine CaMcardiovascular abnormalitiestrypsinized MLCK fragmentschicken gizzardsimatinib-resistant chronic myelogenous leukemiaporcine brain CaMcalmodulin antagonistInhibitorinhibitorinhibit

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