32 Results for "

disulfide bridges

" in MedChemExpress (MCE) Product Catalog:
Products (32)

32 Results for "disulfide bridges" in MCE Product Catalog:

Cat. No.: HY-P2833
CAS No.: 9013-66-5
Synonyms: GSH-Px; EC 1.11.1.9
Research Areas:  

Metabolic Disease

Glutathione Peroxidase (GSH-Px; EC 1.11.1.9) belongs to the peroxidase family and is commonly used in biochemical research. Glutathione Peroxidase can catalyze reduced glutathione (GSH) to form a disulfide bridge with another glutathione molecule, convert it into oxidized glutathione (GSSG), and react with hydrogen peroxide or lipid peroxide reaction, reducing it to H2O. Glutathione Peroxidase is an effective antioxidant against oxidative stress .
loading...
    loading...
Cat. No.: HY-P2695
CAS No.: 118447-40-8
Target:  

Inhibitory Antibodies

Research Areas:  

Infection

STh, an Escherichia coli heat-stable toxin, is a 19 amino acid polypeptide encompassing three disulfide bridges. STh is an antigen of interest in the search for a broad coverage enterotoxigenic Escherichia coli (ETEC) vaccine .
loading...
    loading...
Cat. No.: HY-W106411
CAS No.: 71865-37-7
Synonyms: Dithio-bis-maleimidoethane
Research Areas:  

Others

DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions .
loading...
    loading...
Cat. No.: HY-P3215
CAS No.: 19645-28-4
Target:  

Oxytocin Receptor

Research Areas:  

Endocrinology

Oxytocin parallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
loading...
    loading...
Cat. No.: HY-P3222
CAS No.: 20054-93-7
Target:  

Inhibitory Antibodies

Research Areas:  

Endocrinology

Oxytocin antiparallel dimer is the disulfide-bridged homo peptide dimer. Oxytocin dimer has oxytocin and vasopressin-like activity with less toxic than oxytocin .
loading...
    loading...
Cat. No.: HY-P3026
CAS No.: 37330-34-0
Research Areas:  

Cancer

The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.
loading...
    loading...
Cat. No.: HY-172271
Target:  

Liposome

Research Areas:  

Cancer

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells .
loading...
    loading...
Cat. No.: HY-W615327
CAS No.: 899452-51-8
Research Areas:  

Others

Bis-sulfone NHS Ester is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. These reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
loading...
    loading...
Cat. No.: HY-P5160A
Synonyms: PhlTx1 TFA
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Phlotoxin-1 (PhlTx1) is a 34-amino acid and 3-disulfide bridge peptide. Phlotoxin-1 can be isolated from Phlogiellus genus spider. Phlotoxin-1 is an antinociceptive agent by inhibiting NaV1.7 channel .
loading...
    loading...
Cat. No.: HY-P5182A
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology

HsTX1 (TFA) toxin, from the scorpion Heterometrus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges. HsTX1 (TFA) is an the inhibitor of potassium channel, with IC50 for Kv1.3 of 12 pM and inhibits TEM cell activation and attenuates inflammation in autoimmunity .
loading...
    loading...
Cat. No.: HY-P10654
CAS No.: 2861260-80-0
Target:  

TRP Channel

Research Areas:  

Neurological Disease

RhTx is a transient receptor potential vanillin-1 (TRPV1) activator. RhTx can be used to study pain perception .
loading...
    loading...
Cat. No.: HY-P5917A
Synonyms: Vaejovis mexicanus peptide 24 TFA
Target:  

Potassium Channel

Research Areas:  

Inflammation/Immunology Cancer

Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
loading...
    loading...
Cat. No.: HY-P991150
CAS No.: 2981477-39-6

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ompekimig is an immunoglobulin monoclonal antibody that targets IL-4, IL-13, IL-33. Ompekimig shows potential for use in immune-mediated inflammatory diseases such as asthma and atopic dermatitis .
loading...
    loading...
Cat. No.: HY-P5816
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

BmK-M1 is a scorpion toxin, and is composed of 64 amino acids cross-linked by four disulfide bridges. BmK-M1 inhibits Na + channel and can be considered both as a cardiotoxin and a neurotoxin .
loading...
    loading...
Cat. No.: HY-P3825
CAS No.: 107090-96-0
Synonyms: CCAP
Target:  

Inhibitory Antibodies

Research Areas:  

Cardiovascular Disease

Crustacean cardioactive peptide (CCAP) is a insect cardioregulatory peptides that contmns 9 amino acid, first isolated from the tobacco hawkmoth, Manduca sexta. There are two cystemes at pnsttons 3 and 9 forming a disulfide bridge and the carboxyl-terminns is amldated .
loading...
    loading...
Cat. No.: HY-P1631
CAS No.: 125139-67-5
Target:  

Bacterial

Research Areas:  

Infection

Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges .
loading...
    loading...
Cat. No.: HY-P5159
Target:  

Sodium Channel

Research Areas:  

Inflammation/Immunology

Crotamine is a Na + channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .
loading...
    loading...
Cat. No.: HY-P5159A
Target:  

Sodium Channel

Research Areas:  

Inflammation/Immunology

Crotamine TFA is a Na + channel modulator. Crotamine is a 42 amino acid toxin cross-linked by three disulfide bridges. Crotamine has analgesic activity. Crotamine also interacts with lipid membranes and shows myonecrotic activity. Crotamine can be isolated from Crotalus durissus terrificus venom .
loading...
    loading...
Cat. No.: HY-P4320
CAS No.: 166184-23-2
Target:  

Integrin

Research Areas:  

Cancer

Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge: Cys1-Cys10), a decapeptide containing a cyclic RGD active sequence, is an Integrin αIIbβ3 antagonist that inhibits platelet and Adhesion of proMMP-13 .
loading...
    loading...
Cat. No.: HY-P2434
CAS No.: 846569-60-6
AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research .
loading...
    loading...