11 Results for "

endothelium-dependent relaxation

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "endothelium-dependent relaxation" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-69019
CAS No.: 2942-42-9
Target:  

NO Synthase

7-Nitroindazole is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) (IC50 = 0.47 μM in mouse cerebellum). 7-Nitroindazole does not affect blood pressure or endothelium-dependent relaxation while inhibiting nNOS in experimental animals. 7-Nitroindazole has anti-injurious and neuroprotective properties, and can be studied in research for neurological diseases such as Parkinson’s disease .
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Cat. No.: HY-W005255
CAS No.: 621-54-5
3-(3-Hydroxyphenyl)propionic acid (3HPPA) is an endothelium-dependent nitric oxide (NO) release promoter and endothelial nitric oxide synthase (eNOS) activator. 3-(3-Hydroxyphenyl)propionic acid activates eNOS to mediate vascular smooth muscle relaxation and enhances endothelial cell NO synthesis, inducing vasodilation and reducing peripheral vascular resistance. 3-(3-Hydroxyphenyl)propionic acid can dose-dependently reduce systolic and diastolic blood pressure in spontaneously hypertensive rats (SHR) without affecting cardiac contractility or heart rate. 3-(3-Hydroxyphenyl)propionic acid has antihypertensive and vascular protective effects and can be used in the prevention and treatment of cardiovascular diseases .
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Cat. No.: HY-W010973
CAS No.: 61-47-2
5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock .
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Cat. No.: HY-Y1890B
CAS No.: 61791-12-6
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn 2+ , Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .
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Cat. No.: HY-N11538
CAS No.: 69624-79-9
Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside is a orally active phenolic compound that can be isolated from the Geranium species. Quercetin-3-O-(2′′-O-galloyl)-β-D-glucopyranoside has anti-inflammatory activities and has potential application in edema and aortic endothelium-dependent relaxation injury .
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Cat. No.: HY-W010973S
CAS No.: 2687960-56-9
5-Hydroxytryptamine-d4 creatinine sulfate monohydrate is the deuterated-labeled 5-Hydroxytryptamine creatinine sulfate monohydrate (HY-W010973). 5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock .
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Cat. No.: HY-P4766
CAS No.: 912862-96-5
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

Adrenomedullin (porcine) is a peptide that regulates vasodilation. Adrenomedullin (porcine) induces endothelium-dependent relaxation in rat aorta with IC50 value of 2.4 nM. Adrenomedullin (porcine) induces endothelium-independent relaxation of porcine coronary arteries with an IC50 of 27.6 nM .
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Cat. No.: HY-129210
CAS No.: 864873-81-4
KMUP-4, as a xanthine derivative with cGMP-enhancing activity, induces aortic relaxation through endothelium-dependent and independent mechanisms. KMUP-4 increases cytoplasmic cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) levels by inhibiting phosphodiesterases (PDEs) and activating K + channels. KMUP-4 can be used in the study of cardiovascular diseases .
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Cat. No.: HY-130673
CAS No.: 7672-27-7
Target:  

NO Synthase

Research Areas:  

Cardiovascular Disease

L-NABE is a nitric oxide (NO) synthase inhibitor. L-NABE is also a potent endothelium dependent vasoconstrictor and inhibitor of relaxation .
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Cat. No.: HY-W010973R
CAS No.: 61-47-2
5-Hydroxytryptamine creatinine sulfate monohydrate (Standard) is the analytical standard of 5-Hydroxytryptamine creatinine sulfate monohydrate (HY-W010973). This product is intended for research and analytical applications. 5-Hydroxytryptamine creatinine sulfate monohydrate is a 5-HT receptor agonist and amine oxidase substrate that acts through multiple physiological responses, including induction of vasoconstriction, pressor effects, acceleration of platelet potassium exchange, and endothelium-dependent relaxation, and can serve as a radiolabeled substrate for organelle uptake assays. 5-Hydroxytryptamine creatinine sulfate monohydrate can be used in research on burns, tourniquet and botulinum shock .
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Cat. No.: HY-N20734
CAS No.: 64527-08-8
Synonyms: Polygalacin
Rhamnazin 3-O-rutinoside (Polygalacin) is a flavonoid compound. Rhamnazin 3-O-rutinoside can be extracted from Areca catechu L. Rhamnazin 3-O-rutinoside shows no significant inhibitory effect on recombinant hPTP1B, with an IC50 > 100 μM. Rhamnazin 3-O-rutinoside reduces Apoptotic cell death. Rhamnazin 3-O-rutinoside possesses cellular antioxidant activity and alleviates H2O2-induced oxidative stress. Rhamnazin 3-O-rutinoside lacks free radical scavenging activity. Rhamnazin 3-O-rutinoside can be used in the research of neurodegenerative diseases .
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