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endotoxic

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) Bcl-2 Family (1) Beta-lactamase (1) Biochemical Assay Reagents (1) COX (1) Drug Derivative (1) NO Synthase (4) Opioid Receptor (1) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (5) Infection (1) Inflammation/Immunology (9) Metabolic Disease (4) Neurological Disease (2)

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Fluorescent Dye

Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-18734A

Carboxy-PTIO potassium 5+ Cited Publications	NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

HY-N2359

Chelerythrine	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy	Metabolic Disease Inflammation/Immunology Cancer
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

HY-18734

Carboxy-PTIO	NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO₂. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

HY-101230

ICI 174864	Opioid Receptor	Neurological Disease
ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with K_e values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways .

HY-D2902

SNOTRAP	Biochemical Assay Reagents	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
SNOTRAP (S-nitrosylation trapping by triaryl phosphine) is a chemical probe for S-nitrosylated (SNO) proteins. SNOTRAP based proteomic pipeline can identify 1181 SNO proteins (1714 SNO sites) in the brain of mouse models. SNOTRAP can be used for nitrosative stress related diseases such as neurodegenerative disease, endotoxic shock, cancer, multiple sclerosis, and sickle cell disease .

HY-114531

Lomifylline	Drug Derivative	Others
Lomifylline is a derivative of Xanthine (HY-W017389). Lomifylline can be used in research of sepsis and septic or endotoxic shock, when combined with an antibody to TNF or a TNF binding fragment .

HY-N10106

Dihydromyristicin	Reactive Oxygen Species (ROS)	Inflammation/Immunology
Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways .

HY-18734AR

Carboxy-PTIO potassium (Standard)	NO Synthase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Carboxy-PTIO (potassium) (Standard) is the analytical standard of Carboxy-PTIO (potassium). This product is intended for research and analytical applications. Carboxy-PTIO potassium is a potent nitric oxide (NO) scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO potassium can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model .

HY-138454

MEG hemisulfate Mercaptoethylguanidine hemisulfate	NO Synthase	Inflammation/Immunology
MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC₅₀s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock .

HY-N3866

Esculentic acid	COX	Inflammation/Immunology
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

HY-180341

UR-12633	Platelet-activating Factor Receptor (PAFR)	Inflammation/Immunology
UR-12633 is a platelet-activating factor (PAF) antagonist. UR-12633 can effectively reverse hypotension, inhibit coagulation abnormalities, increased vascular permeability, and metabolic disorders in rodent models of endotoxic shock. UR-12633 can be used for research on endotoxic shock .

SNOTRAP	Fluorescent Dye
SNOTRAP (S-nitrosylation trapping by triaryl phosphine) is a chemical probe for S-nitrosylated (SNO) proteins. SNOTRAP based proteomic pipeline can identify 1181 SNO proteins (1714 SNO sites) in the brain of mouse models. SNOTRAP can be used for nitrosative stress related diseases such as neurodegenerative disease, endotoxic shock, cancer, multiple sclerosis, and sickle cell disease .

Cat. No.	Product Name	Target	Research Area

HY-101230

ICI 174864	Opioid Receptor	Neurological Disease
ICI 174864 is a selective and brain-penetrant δ-opioid receptor antagonist with K_e values of 22.0 nM to 30.6 nM at δ-opioid receptor in mouse vas deferens. ICI 174864 selectively blocks biological effects mediated by the δ-opioid receptor agonist DPDPE (HY-P1334) after central administration. ICI 174864 reverses hypotension in rats with endotoxic shock and inhibits acetic acid-induced writhing in mice. ICI 174864 can be used for the research of opioid receptor subtypes, endotoxic hypotension and analgesic pathways .

HY-P10186

Myristoylated ARF6 (2-13), scrambled	Peptides	Cardiovascular Disease
Myristoylated ARF6 (2-13), scrambled is a peptide , and is composed of amino acids 2–13 of ARF6 (MyrARF6 2–13) .

Chelerythrine	Alkaloids Classification of Application Fields Metabolic Disease Macleaya cordata (Willd.) R. Br. Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Papaveraceae Source Classification	Beta-lactamase PKC Bcl-2 Family Apoptosis Autophagy
Chelerythrine is a natural alkaloid, acts as a potent and selective Ca ²⁺/phospholopid-dependent PKC antagonist, with an IC₅₀ of 0.7 μM . Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity . Chelerythrine inhibits the BclXL-Bak BH3 peptide binding with IC₅₀ of 1.5 μM and displaces Bax from BclXL. Chelerythrine triggers apoptosis and autophagy .

Dihydromyristicin	Natural Products Classification of Application Fields Centaurea aspera stenophylla Plants Umbelliferae Disease Research Fields Inflammation/Immunology Source Classification	Reactive Oxygen Species (ROS)
Dihydromyristicin, a plant flavonoid, has potent anti-inflammatory properties. Dihydromyristicin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways .

Esculentic acid	Triterpenes Terpenoids Labiatae Plants Source Classification Vachellia nilotica (L.) P. J. H. Hurter & Mabb.	COX
Esculentic acid is a selective COX-2 inhibitor and has anti-inflammatory effect. Esculentic acid is a pentacyclic triterpenoid that can be extracted from the Chinese herb Phytolacca esculenta .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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