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eukaryotic translation initiation factor 4E (eIF4E)

" in MedChemExpress (MCE) Product Catalog:

標的別:	Eukaryotic Initiation Factor (eIF) (5) Apoptosis (2) c-Myc (2) Caspase (2) CDK (2) DNA/RNA Synthesis (1) MDM-2/p53 (2) Microtubule/Tubulin (1) MNK (1)
研究分野別:	Cancer (6) Neurological Disease (1)

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Targets Recommended: Eukaryotic Initiation Factor (eIF)

製品番号	製品名	Target	研究分野	構造式

HY-16366

Briciclib ON 014185	Eukaryotic Initiation Factor (eIF) CDK c-Myc MDM-2/p53 Caspase Apoptosis	Cancer
Briciclib (ON 014185) is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib can be used for the study of hematological system tumors and solid tumors .

HY-148664

eIF4E-IN-4	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4E-IN-4 (Compound 33) is a selective inhibitor of **eukaryotic initiation factor 4E (eIF4E)** with biochemical activity value of 95 nM. eIF4E-IN-4 inhibits cap-dependent mRNA translation with an IC₅₀ value of 2.5 μM. eIF4E-IN-4 can be used for breast cancer, colon cancer, and head and neck cancer study .

HY-168326

Antiproliferative agent-64	DNA/RNA Synthesis Microtubule/Tubulin	Cancer
Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC₅₀ of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC₅₀ of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC₅₀ of 7 nM .

HY-184004

NUCC-0231068	MNK Eukaryotic Initiation Factor (eIF)	Neurological Disease Cancer
NUCC-0231068 is a MNK1 and MNK2 inhibitor with IC₅₀ values of 8 nM and 7 nM, respectively. NUCC-0231068 inhibits the phosphorylation of eukaryotic translation initiation factor 4E (eIF4E) at Ser209, with an IC₅₀ of 23 nM in its purified form and 17 nM in its D2B form. NUCC-0231068 can be used in studies related to glioblastoma .

HY-16366A

Briciclib sodium ON 014185 sodium	Eukaryotic Initiation Factor (eIF) CDK c-Myc MDM-2/p53 Caspase Apoptosis	Cancer
Briciclib (ON 014185) sodium is a eukaryotic translation initiation factor 4E (eIF4E) inhibitor. Briciclib sodium exhibits broad-spectrum anti-cancer activity, including in mantle cell leukemia, breast cancer, gastric cancer, and esophageal cancer cells. Briciclib sodium reduces the expression of cyclin D1 and c-Myc, and enhances the expression of P53 and Cleaved Caspase 3 pro-apoptotic proteins. Briciclib sodium can be used for the study of hematological system tumors and solid tumors .

HY-155676

eIF4E-IN-5	Eukaryotic Initiation Factor (eIF)	Cancer
eIF4E-IN-5 (Compound 6n) is a eIF4E cell-permeable inhibitor. eIF4E-IN-5 can bind to capped mRNA to inhibit cap-dependent translation .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P70152

	EIF4E Protein, Human rHueukaryotic translation initiation factor 4E/EIF4E; eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein; EIF4E; EIF4EL1; EIF4F	Human	E. coli
	IF4E protein plays multiple roles in cells, regulating processes such as protein synthesis, mRNA export, RNA processing and splicing. As part of the eIF4F protein complex, IF4E recognizes the mRNA cap and promotes ribosome binding. It is also involved in translation repression and regulation of mRNA stability. In P bodies, IF4E is involved in storing translationally inactive mRNA. In addition, IF4E also plays a role in spermatogenesis, neurogenesis, and mRNA nuclear-cytoplasmic transport. The ability of IF4E to participate in mRNA export relies on binding to the m7G cap and the EIF4E-sensitive element (4ESE). LRPPRC promotes the formation of EIF4E-dependent mRNA export complexes. The action of IF4E changes the composition of nuclear pores and promotes the nuclear export of specific mRNAs. EIF4E Protein, Human is the recombinant human-derived EIF4E protein, expressed by E. coli , with tag free.

HY-P70416

	EIF4EBP2 Protein, Human (His) rHueukaryotic translation initiation factor 4E-binding protein 2/EIF4EBP2, His; eukaryotic translation initiation factor 4E-Binding Protein 2; 4E-BP2; eIF4E-Binding Protein 2; EIF4EBP2	Human	E. coli
	EIF4EBP2 is a translation initiation repressor protein that plays a critical regulatory role in synaptic plasticity, learning, and memory. In the hypophosphorylated state, EIF4EBP2 competes with EIF4G1/EIF4G3, forms a complex with EIF4E, and inhibits translation. EIF4EBP2 Protein, Human (His) is the recombinant human-derived EIF4EBP2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P70415

	EIF4EBP1 Protein, Human (His) rHueukaryotic translation initiation factor 4E-binding protein 1/EIF4EBP1, His; eukaryotic translation initiation factor 4E-Binding Protein 1; 4E-BP1; eIF4E-Binding Protein 1; Phosphorylated Heat- and Acid-Stable Protein Regulated by Insulin 1; PHAS-I; EIF4EBP1	Human	E. coli
	EIF4EBP1 is a translation initiation repressor protein that complexly regulates EIF4E activity. In the hypophosphorylated state, EIF4EBP1 competes with EIF4G1/EIF4G3 to inhibit translation by binding to EIF4E. EIF4EBP1 Protein, Human (His) is the recombinant human-derived EIF4EBP1 protein, expressed by E. coli , with N-6*His labeled tag.

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Host:	Mouse (3) Rabbit (9)
Reactivity:	Transfected (2) Human (10) Rat (9) Mouse (9) Hamster (2)
Application:	IHC-P (9) ICC/IF (6) IP (8) IHC-F (2) WB (12) FC (1) ELISA (4)
Isotype:	IgG (8) IgG/Kappa (1)
Conjugation:	Non-conjugated (12)
Clonality:	Monoclonal (9) Recombinant (3)
Modification:	Phosphorylated (3) Unmodified (6)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85133

	eIF4E Antibody (YA4825) EIF4E; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-P, ICC/IF, FC, ELISA	Human
	eIF4E Antibody (YA4825) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4E.

HY-P86175

	eIF4E Antibody (YA5867) EIF4E; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	eIF4E Antibody (YA5867) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4E.

HY-P85623

	eIF4EBP3 Antibody (YA5315) 4E BP3; 4E-BP3; 4EBP3; eIF4E binding protein 3; eukaryotic initiation factor 4E binding protein 3; eukaryotic translation initiation factor 4E binding protein 3; OTTHUMP00000159879.	WB	Transfected
	eIF4EBP3 Antibody (YA5315) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP3.

HY-P80812

	Phospho-eIF4E (Ser209) Antibody (YA202) EIF4E; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-eIF4E (Ser209) Antibody (YA202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4E (Ser209).

HY-P80812A

	Phospho-eIF4E (Ser209) Antibody (YA202)(PBS only) EIF4E; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E; eIF-4E; eIF4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	Phospho-eIF4E (Ser209) Antibody (YA202) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4E (Ser209).

HY-P85622

	eIF4EBP2 Antibody (YA5314) 4E-BP2; 4EBP2; 4EBP2_HUMAN; eIF4E binding protein 2; eIF4E-binding protein 2; Eif4Ebp2; eukaryotic translation initiation factor 4E binding protein 1; eukaryotic translation initiation factor 4E-binding protein 2; PHASII; phosphorylated, heat and acid stable regulated by insulin protein II.	WB	Transfected
	eIF4EBP2 Antibody (YA5314) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to eIF4EBP2.

HY-P80526

	eIF4EBP1 Antibody (YA650) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	eIF4EBP1 Antibody (YA650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P86332

	eIF4EBP1 Antibody (YA6024) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	eIF4EBP1 Antibody (YA6024) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P80786

	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1 (Thr46).

HY-P80526A

	eIF4EBP1 Antibody (YA650)(PBS only) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat, Hamster
	eIF4EBP1 Antibody (YA650) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to eIF4EBP1.

HY-P86088

	Phospho-eIF4EBP1(Thr37/46) Antibody (YA5780) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-eIF4EBP1(Thr37/46) Antibody (YA5780) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1(Thr37/46).

HY-P80786A

	Phospho-eIF4EBP1 (Thr46) Antibody (YA230)(PBS only) EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I	WB, IHC-P, IP	Human, Mouse, Rat
	Phospho-eIF4EBP1 (Thr46) Antibody (YA230) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-eIF4EBP1 (Thr46).

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