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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
hGLP-1R knock-in mice
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "hGLP-1R knock-in mice" in MCE Product Catalog:
Cat. No.: HY-173479
CAS No.: 3108380-54-4
Target:
Research Areas:
GLP-1R agonist 30 is a selective and orally active GLP-1R agonist with an EC50 of 0.048 nM. GLP-1R has excellent selectivity, with EC50 greater than 20 μM for GLP-2R, GIPR, and GCPR. GLP-1R agonist significantly increases cAMP-stimulating activity while markedly reducing hERG inhibitory activities. GLP-1R agonist has preferable absorption and excellent β-arrestin pathway selectivity. GLP-1R agonist effectively improves glucose tolerance and promoted insulin secretion in B-hGLP1R knock-in mice .
Cat. No.: HY-189219
Target:
Research Areas:
GLP-1R modulator-3 is an orally active positive allosteric modulator of GLP-1R, with a Kd of 11.4 μM. GLP-1R modulator-3 exhibits no intrinsic GLP-1R agonistic activity. GLP-1R modulator-3 exerts a hypoglycemic effect in hGLP-1R knock-in mice. GLP-1R modulator-3 is applicable for the research of type 2 diabetes .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
