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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
human cereblon (CRBN)
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "human cereblon (CRBN)" in MCE Product Catalog:
Cat. No.: HY-151886
CAS No.: 2759420-43-2
Research Areas:
NU223612 is a cereblon (CRBN)-recruiting IDO1 PROTAC degrader, with a DC50 value of 0.329-0.5438 μM against human IDO1, and it is capable of penetrating the blood-brain barrier. NU223612 directly binds to IDO1, mediates the degradation of both wild-type and catalytically inactive mutant IDO1 proteins, and does not degrade TDO2. NU223612 inhibits IDO1-mediated enzymatic activity. NU223612 directly binds to CRBN and promotes the formation of a cooperative ternary complex with IDO1. NU223612 induces ubiquitin-dependent proteasomal degradation of the IDO1 protein. NU223612 suppresses IDO1-mediated non-enzymatic phosphorylation of NF-κB p65 and the DNA-binding activity of downstream transcription factors. NU223612 can be used in studies of glioblastoma (malignant glioma) .
Target:
Research Areas:
BODIPY FL thalidomide is a high-affinity and selective human cereblon (CRBN)-targeting fluorescent probe with a Kd of 3.6 nM. BODIPY FL thalidomide enables use as a probe in time-resolved fluorescence resonance energy transfer (TR-FRET) binding assays for cereblon ligands. BODIPY FL thalidomide supports development of highly sensitive, selective, stable cereblon TR-FRET binding assays (Ex/Em = 502/510 nm) .
Cat. No.: HY-170448
Research Areas:
PROTAC AR Degrader-9 is a topically applicable androgen receptor (AR) PROTAC degrader. PROTAC AR Degrader-9 recruits Cereblon (CRBN) E3 ubiquitin ligase to induce AR ubiquitination and proteasomal degradation in human dermal papilla cells (HDPCs) with a DC50 of 262.38 nM. PROTAC AR Degrader-9 possesses excellent skin retention, modulates androgenetic alopecia (AGA)-related downstream paracrine factors including TGF-β1 and β-catenin, promotes hair regeneration in mice. and exhibits favorable skin pharmacokinetics profiles with minimal systemic exposure. PROTAC AR Degrader-9 can be used for the study of androgenetic alopecia (AGA) .
Cat. No.: HY-P705555
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Protein cereblon; CRBN AD-006
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702820
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A
Species:
Human
Source:
E. coli
Cat. No.: HY-P702818
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A
Species:
Human
Source:
HEK293
Cat. No.: HY-P86823
Synonyms: 2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; cereblon antibody; Crbn antibody; CRBN_human antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; 2610203G15Rik antibody; 2900045O07Rik antibody; AF229032 antibody; AW108261 antibody; cereblon antibody; Crbn antibody; CRBN_human antibody; DKFZp781K0715 antibody; MGC27358 antibody; MRT2A antibody; OTTHUMP00000209555 antibody; piL antibody; Protein cereblon antibody; Protein x 0001 antibody;
Cat. No.: HY-P702825
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702850
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-P702851
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-181311
Target:
Research Areas:
CCT400028 is a PROTACs-class degrader that targets the Aurora A (AURKA) kinase. CCT400028 induces ubiquitination and proteasomal degradation of target proteins by recruiting the cereblon (CRBN) E3 ubiquitin ligase. The KD values of CCT400028 against the three subtypes of human AURKA are 71 nM, 2100 nM and >10000 nM, respectively, and its IC50 against human CRBN is 6300 nM. CCT400028 is applicable to relevant research on leukemia, neuroblastoma and glioma .
Cat. No.: HY-P706007
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-W1135319
Target:
Research Areas:
SB-405483 is a CRBN orthosteric ligand bindign enhancer. SB-405483 potentiates degradation of CRBN substrates including CK1α, Wee1, IKZF1/3. SB-405483 stabilizes CRBN and reduces CRBN autoubiquitination. SB-405483 can be used for the research of cancer, such as multiple myeloma and acute myeloid leukemia .
Cat. No.: HY-P702817
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
HEK293
Cat. No.: HY-P702826
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CRBN; MRT2; Prev. MRT2A; Protein X 0001; Protein cereblon; cereblon; Mental Retardation, Non-Syndromic, Autosomal Recessive, 2A; DDB1; XPE-BF; Damage Specific DNA Binding Protein 1; XAP-1; DNA Damage-Binding Protein 1; XAP1; Xeroderma Pigmentosum Group E-
Species:
Human
Source:
Sf9 insect cells
Cat. No.: HY-179467
CAS No.: 2892306-56-6
Target:
Research Areas:
PROTAC hCAII degrader-1 is a potent PROTAC human carbonic anhydrase II (hCAII) degrader with an DC50 of 0.5 nM in HEK293 cells. PROTAC hCAII degrader-1 recruits cereblon (CRBN) E3 ubiquitin ligase to form a ternary complex. PROTAC hCAII degrader-1 enables ubiquitination and subsequent proteasomal degradation of hCAII .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
