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Results for "

influenza RNA-dependent RNA polymerase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA/RNA Synthesis (19) Influenza Virus (24) Apoptosis (2) Autophagy (3) Bacterial (6) Fungal (2) Isotope-Labeled Compounds (3) mTOR (3) Parasite (2) Reference Standards (3) SARS-CoV (4)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Infection (24) Inflammation/Immunology (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Influenza Virus MicroRNA mRNA RNA MTase Small Interfering RNA (siRNA) PARP DNA/RNA Synthesis Aminoacyl-tRNA Synthetase

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-14768

Favipiravir Maximum Cited Publications 50 Publications Verification T-705	DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial	Infection
Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-N0112

Dihydromyricetin Maximum Cited Publications 23 Publications Verification Ampelopsin; Ampeloptin	mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent **influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀** of 22 μM.

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal	Infection Cardiovascular Disease Cancer
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards	Infection Cancer
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-162793

RdRP-IN-8	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-8 (compound 45) is an anti-influenza virus compound. RdRP-IN-8 inhibits viral RNA-dependent RNA polymerase (RdRP) activity by disrupting heterodimerization of PA and PB1 subunits (EC₅₀=0.13 μM) .

HY-156440

7-51A	Influenza Virus	Infection
7-51A is a potent PB2 inhibitor with a KD value of 1.64 nM as determined by ITC. PB2 is an essential subunit of influenza RNA-dependent RNA polymerase (RdRP).

HY-14768A

Favipiravir sodium T-705 sodium	DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial	Infection
Favipiravir (T-705) sodium is an inhibitor of viral RNA polymerase (RNA *polymerase), which is converted into its active form Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the activity of influenza* virus RNA-dependent RNA polymerase (RdRP) with an IC₅₀ of 341 nM .

HY-155110

Antiviral agent 34	DNA/RNA Synthesis Influenza Virus	Infection
Antiviral agent 34 is a potent and orally active antiviral agent against *influenza* A and B subtypes with an EC₅₀ value of 0.8 nM for H1N1 proliferation. Antiviral agent 34 derivatives inhibited influenza virus proliferation by targeting influenza virus RNA-dependent RNA polymerase. Antiviral agent 34 can be used for influenza virus research .

HY-170440

ATV2301	Influenza Virus	Infection Inflammation/Immunology
ATV2301 is an orally active *anti-influenza* agent (EC₅₀, H1N1 = 1.88 nM, H3N2 = 4.77 nM). ATV2301’s anti-influenza activity is due to its effects on polymerase acid protein (PA), nuclear protein (NP), and RNA-dependent RNA polymerase (RdRp) .

HY-14768R

Favipiravir (Standard) T-705 (Standard)	Reference Standards DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial	Infection
Favipiravir (Standard) is the analytical standard of Favipiravir. This product is intended for research and analytical applications. Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-14768S

Favipiravir-13C15N T-705-¹³C¹⁵N	Isotope-Labeled Compounds Bacterial DNA/RNA Synthesis SARS-CoV Influenza Virus	Infection
Favipiravir- ¹³C ¹⁵N (T-705- ¹³C ¹⁵N) is ¹³C and ¹⁵N labeled Favipiravir. Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-N0112R

Dihydromyricetin (Standard) Ampelopsin (Standard); Ampeloptin (Standard)	Reference Standards mTOR Influenza Virus DNA/RNA Synthesis Autophagy	Infection Cancer
Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

HY-115730

RdRP-IN-3	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-3 is a promising anti-influenza agent candidate by inhibiting the activity of RNA-dependent RNA polymerase (RdRp).

HY-152239

RdRP-IN-5	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-5 (compound 20) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. RdRP-IN-5 can be used in research of influenza virus .

HY-152239B

trans-RdRP-IN-11	DNA/RNA Synthesis Influenza Virus	Infection
trans-RdRP-IN-5 (compound 18) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. trans-RdRP-IN-5 can be used in research of influenza virus .

HY-152239A

cis-RdRP-IN-11	DNA/RNA Synthesis Influenza Virus	Infection
cis-RdRP-IN-5 (compound 19) is a potent influenza virus RNA-dependent RNA polymerase (RdRP) inhibitor. cis-RdRP-IN-5 can be used in research of influenza virus .

HY-168510

ATV03	Influenza Virus	Infection
ATV03 is an anti-influenza virus agent with excellent *anti-influenza* A and B virus** activity. ATV03 inhibits anti-influenza A (H3N2) and anti-influenza B with EC₅₀ values of 0.78 nM and 2.02 nM, respectively. ATV03 exerts anti-influenza activity by inhibiting polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as disrupting nuclear protein .

HY-W769714

Favipiravir-13C3 T-705-¹³C₃	Isotope-Labeled Compounds DNA/RNA Synthesis Influenza Virus	Infection
Favipiravir- ¹³C3 is the ¹³C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-163147

PAN endonuclease-IN-1	Influenza Virus DNA/RNA Synthesis	Infection
PAN endonuclease-IN-1 (Compound 23) is a potent PAN endonuclease inhibitor, with K_d values of 277 μM, 384 μM and 328 μM for WT, I38T and E23K PA_N endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal (PAN) endonuclease, a critical component of influenza viral replication machinery, is an antiviral target .

HY-N0112S

Dihydromyricetin-d4 Ampelopsin-d₄; Ampeloptin-d₄	Isotope-Labeled Compounds Autophagy Influenza Virus mTOR DNA/RNA Synthesis	Infection Cancer
Dihydromyricetin-d₄ (Ampelopsin-d₄) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent **influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀** of 22 μM.

HY-144668

RdRP-IN-4	DNA/RNA Synthesis Influenza Virus	Infection
RdRP-IN-4 (compound 11q), an aryl benzoyl hydrazide analog, is an orally active influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor by interacting with the PB1 subunit. RdRP-IN-4 exhibits potent inhibitory activity against the avian H5N1 flu strain with an EC50 of 18 nM in MDCK cells. RdRP-IN-4 displays excellent potency against the the H1N1 (A/PR/8/34) Flu A strain and Flu B strain (B/Lee/1940) with EC50 values of 53 nM and 20 nM, respectively. RdRP-IN-4 significantly inhibits the expression level of viral nucleoprotein (NP) in a dose-dependent manner. RdRP-IN-4 exhibits significant antiviral activity in infected mice .

HY-180269

Anti-Influenza agent 10	Influenza Virus DNA/RNA Synthesis	Infection
Anti-Influenza agent 10 (Compound 41) is an influenza A virus RNA-dependent RNA polymerase (RdRp) inhibitor. Anti-Influenza agent 10 exhibits potent antiviral activity against A/PR/8/34(H1N1) with an IC₅₀ of 0.29μM and a K_D of 4.11 μM. Anti-Influenza agent 10 can inhibit the assembly of the viral RdRp complex by disrupting the protein interaction between PA and PB1 subunits, thereby blocking the transcription and replication of the viral genome. Anti-Influenza agent 10 shows significant broad-spectrum effects on multiple influenza virus strains, such as H3N2, H3N8 and H9N2 with IC₅₀ values of 3.96, 1.91 and 1.45 μM. Anti-Influenza agent 10 can be used for the research of influenza A Virus Infection .

HY-178455

Influenza virus-IN-10	Influenza Virus	Infection
Influenza virus-IN-10 is a dual-target antiviral agents for influenza that targets both PA_C (K_D = 8.9 μM) and NP (K_D = 52.5 μM) simultaneously. Influenza virus-IN-10 exhibits an EC₅₀ values of 1.64 μM) against influenza A virus (H1N1, A/WSN/33) and broad-spectrum activity against other influenza strains, including influenza B virus and multiple subtypes of influenza A .

HY-180525

PB2-IN-2	Influenza Virus	Infection
PB2-IN-2 is an orally active PB2 inhibitor with RNA-dependent RNA Polymerase (RNP) IC₅₀ = 0.2 nM, LRA (Ligand Receptor Assay) EC₅₀ = 0.8 nM, Cytopathic Effect (CPE) EC₅₀ = 0.1 nM. PB2-IN-2 exhibits broad-spectrum, nanomolar antiviral potency against a panel of influenza A strains (including H1N1pdm09, Lyon/1337/2007/H1N1, Tex12-Like/H3N2, PR/8/34/H1N1, WSN/1933/H1N1, rPR8(H1N1)/H7N9 with EC₅₀ = 1.5, 3.6, 3.7, 13.8, 2.9 and 9.8 nM and all the CC₅₀ values > 2 μM. PB2-IN-2 possesses an excellent pharmacokinetic profile and metabolic stability. PB2-IN-2 can be used for anti-influenza research .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-N0112

Dihydromyricetin Maximum Cited Publications 23 Publications Verification Ampelopsin; Ampeloptin	Infection Flavanonols Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification	mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent **influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀** of 22 μM.

HY-N0540

Cynaroside 10+ Cited Publications Luteolin 7-glucoside; Luteolin 7-O-β-D-glucoside	Infection Structural Classification Flavonoids Classification of Application Fields Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants Disease Research Fields	Influenza Virus DNA/RNA Synthesis Apoptosis Parasite Bacterial Fungal
Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N0540R

Cynaroside (Standard) 10+ Cited Publications Luteolin 7-glucoside (Standard); Luteolin 7-O-β-D-glucoside (Standard)	Structural Classification Flavonoids Flavones Centaurea ornata Phenols Polyphenols Umbelliferae Plants	Apoptosis DNA/RNA Synthesis Parasite Bacterial Influenza Virus Fungal Reference Standards
Cynaroside (Standard) is the analytical standard of Cynaroside. This product is intended for research and analytical applications. Cynaroside (Luteolin 7-glucoside) is a flavonoid compound that exhibits anti-oxidative capabilities. Cynaroside is also a potent influenza RNA-dependent **RNA polymerase inhibitor with an IC₅₀** of 32 nM. Cynaroside also is a promising inhibitor for H₂O₂-induced apoptosis, has cytoprotection against oxidative stress-induced cardiovascular diseases. Cynaroside also has antibacterial, antifungal and anticancer activities, antioxidant and anti-inflammatory activities .

HY-N0112R

Dihydromyricetin (Standard) Ampelopsin (Standard); Ampeloptin (Standard)	Flavanonols Structural Classification Flavonoids other families Phenols Polyphenols Plants Source Classification	Reference Standards mTOR Influenza Virus DNA/RNA Synthesis Autophagy
Dihydromyricetin (Standard) is the analytical standard of Dihydromyricetin. This product is intended for research and analytical applications. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

Cat. No.	Nombre del producto	Chemical Structure

HY-14768S

Favipiravir-13C15N
Favipiravir- ¹³C ¹⁵N (T-705- ¹³C ¹⁵N) is ¹³C and ¹⁵N labeled Favipiravir. Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

Favipiravir-13C15N

Favipiravir- ¹³C ¹⁵N (T-705- ¹³C ¹⁵N) is ¹³C and ¹⁵N labeled Favipiravir. Favipiravir (T-705) is a potent viral RNA polymerase inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-W769714

Favipiravir-13C3
Favipiravir- ¹³C3 is the ¹³C labeled isotope of Favipiravir (HY-14768). Favipiravir (T-705) is a potent viral **RNA polymerase** inhibitor, it is phosphoribosylated by cellular enzymes to its active form, Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the influenza viral RNA-dependent RNA polymerase (RdRP) activity with an IC₅₀ of 341 nM.

HY-N0112S

Dihydromyricetin-d4
Dihydromyricetin-d₄ (Ampelopsin-d₄) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent **influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀** of 22 μM.

Dihydromyricetin-d4

Dihydromyricetin-d₄ (Ampelopsin-d₄) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC₅₀ of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC₅₀ of 22 μM.

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