2. Cell Cycle/DNA Damage Anti-infection
  3. DNA/RNA Synthesis Influenza Virus SARS-CoV Bacterial
  4. Favipiravir sodium

Favipiravir (T-705) sodium is an inhibitor of viral RNA polymerase (RNA polymerase), which is converted into its active form Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the activity of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 of 341 nM.

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CAS No. : 1366418-99-6

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    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2025 Dec;14(1):2564308.  [Abstract]

    Drug susceptibility profiles of Favipiravir were assessed using a viral yield reduction assay in MDCK cells. Cells were infected with IDV and IAV (MOI = 0.1), followed by removal of the virus inoculum and treatment with the drugs. Supernatants from IDV and Influenza A virus (IAV) infections were collected at 72 and 48 hpi, respectively, and viral titres were determined in MDCK cells. Antiviral activity (%) was calculated relative to virus-free and drug-free controls.

    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 16;10:1203.  [Abstract]

    Vero E6 cells in 12-well plates were infected with HTNV at an FFU of 30/well (T-705; Favipiravir) and incubated with a CMC overlay supplemented with serial two-fold dilutions of inhibitors. At 5 dpi, the foci were counted and calculated. These experiments were performed independently at least three times with similar results.

    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 16;10:1203.  [Abstract]

    Inhibitory effects of T-705 (Favipiravir) and BXA (Baloxavir) on HTNV replication, as measured by FFA. Vero E6 cells were infected with HTNV at an FFU of 30/well (T-705) or 50/well (BXA) and treated with serial two-fold dilutions of inhibitors. The foci were counted 5 dpi. Each point represents the mean and SD of three independent experiments.

    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 16;10:1203.  [Abstract]

    Cell viability as a percentage of the control cell (treated with DMSO for T-705 or PBS for BXA) viability in uninfected Vero E6 cells incubated for 72 h post-T-705 (Favipiravir)/BXA (Baloxavir) treatment. Each point represents the mean and SD of three independent experiments.

    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: BMC Vet Res. 2019 Sep 2;15(1):316.  [Abstract]

    Comparisons of antiviral effects of T-705 and anti-CDV polyclonal serum. The Vero and DH82 cells were treated with T-705 (156.25 μg/ml), anti-CDV polyclonal serum (1:128) and a combination of T-705 (156.25 μg/ml) and anti-CDV polyclonal serum (1:128) at 0, 12, 24, 36 and 48 h p.i. with CDV-3 and CDV-11 at a MOI of 0.1. The mock groups were treated with DMEM p.i. at the same times. Viral replications in cells were detected by IFA and the mean fluorescence percentages (a, c, e, g) were calculated

    Favipiravir sodium purchased from MedChemExpress. Usage Cited in: BMC Vet Res. 2019 Sep 2;15(1):316.  [Abstract]

    Comparisons of antiviral effects of T-705 and anti-CDV polyclonal serum. The Vero and DH82 cells were treated with T-705 (156.25 μg/ml), anti-CDV polyclonal serum (1:128) and a combination of T-705 (156.25 μg/ml) and anti-CDV polyclonal serum (1:128) at 0, 12, 24, 36 and 48 h p.i. with CDV-3 and CDV-11 at a MOI of 0.1. The mock groups were treated with DMEM p.i. at the same times. The virus titers in supernatant (b, d, f, h) were determined and compared with the viral titers in mock group. All e

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    Description

    Favipiravir (T-705) sodium is an inhibitor of viral RNA polymerase (RNA polymerase), which is converted into its active form Favipiravir-ribofuranosyl-5′-triphosphate (RTP). Favipiravir-RTP inhibits the activity of influenza virus RNA-dependent RNA polymerase (RdRP) with an IC50 of 341 nM[1][2].

    IC50 & Target

    RNA Polymerase

     

    Molecular Weight

    179.08

    Formula

    C5H3FN3NaO2
    CAS No.
    SMILES

    O=C(C1=NC(F)=CN=C1O[Na])N
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Favipiravir1366418-99-6T-705T705T 705DNA/RNA SynthesisInfluenza VirusSARS-CoVBacterialSARS coronavirusInhibitorinhibitorinhibit

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