615-16-7
Chemical Structure
2-Hydroxybenzimidazole
- No. CAS: 615-16-7
- Formula:C7H6N2O
- Molecular Weight:134.14
IUPAC Name: 1,3-dihydro-2H-benzo[d]imidazol-2-one
InChIKey: SILNNFMWIMZVEQ-UHFFFAOYSA-N
SMILES: O=C1NC2=CC=CC=C2N1
Biological Activity: 2-Hydroxybenzimidazole is a metabolite of Carbendazim (HY-13582). 2-Hydroxybenzimidazole is produced by the degradation of Carbendazim (HY-13582) by mycobacteria. 2-Hydroxybenzimidazole does not induce CYP1A1 protein expression and does not significantly reduce mortality in mice after influenza virus challenge following intranasal administration. 2-Hydroxybenzimidazole can be used in research on tobacco mosaic virus infection and influenza[1][2][3][4][5][6][7][8][9].
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2-Hydroxybenzimidazole | 99.98% | 2-Hydroxybenzimidazole is a metabolite of Carbendazim (HY-13582). 2-Hydroxybenzimidazole is produced by the degradation of Carbendazim (HY-13582) by mycobacteria. 2-Hydroxybenzimidazole does not induce CYP1A1 protein expression and does not significantly reduce mortality in mice after influenza virus challenge following intranasal administration. 2-Hydroxybenzimidazole can be used in research on tobacco mosaic virus infection and influenza. | ||||||||||||||||||||
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2-Hydroxybenzimidazole (Standard) | ≥98% | 2-Hydroxybenzimidazole (Standard) is the analytical standard of 2-Hydroxybenzimidazole (HY-W008003). This product is intended for research and analytical applications. 2-Hydroxybenzimidazole is a metabolite of Carbendazim (HY-13582). 2-Hydroxybenzimidazole is produced by the degradation of Carbendazim (HY-13582) by mycobacteria. 2-Hydroxybenzimidazole does not induce CYP1A1 protein expression and does not significantly reduce mortality in mice after influenza virus challenge following intranasal administration. 2-Hydroxybenzimidazole can be used in research on tobacco mosaic virus infection and influenza. | ||||||||||||||||||||
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References
- [1]. Cassells AC, et al. Antiviral Activity of 2-(a-Hydroxybenzyl)-Benzimidazole and other 2-Substituted Benzimidazoles against TMV in Tomato Leaf Discs.
- [2]. Zhang Y, et al. Identification of the key amino acid sites of the carbendazim hydrolase (MheI) from a novel carbendazim-degrading strain Mycobacterium sp. SD-4. Journal of Hazardous Materials. 2017 Jun 5;331:55-62.
- [3]. Bai N, et al. Rhamnolipid-aided biodegradation of carbendazim by Rhodococcus sp. D-1: Characteristics, products, and phytotoxicity. Science of the Total Environment. 2017 Jul 15;590:343-51. [Content Brief]
- [4]. Ji L, et al. Isolation and characterization of the carbendazim-degrading strain Djl-5B[J]. Nature Environment and Pollution Technology, 2016, 15(1): 97.
- [5]. Yang Y, et al. Effects of superabsorbent polymers on the fate of fungicidal carbendazim in soils. Journal of hazardous materials. 2017 Apr 15;328:70-79. [Content Brief]
- [6]. Wang Z, et al. Biodegradation of carbendazim by a novel actinobacterium Rhodococcus jialingiae djl-6-2. Chemosphere. 2010 Oct;81(5):639-44. [Content Brief]
- [7]. Zhang X, et al. Isolation and characterization of carbendazim-degrading Rhodococcus erythropolis djl-11. PloS one. 2013;8(10):e74810. [Content Brief]
- [8]. Backlund M, et al. Structural and mechanistic aspects of transcriptional induction of cytochrome P450 1A1 by benzimidazole derivatives in rat hepatoma H4IIE cells. European Journal of Biochemistry. 1999 Mar 19;261(1):66-71. [Content Brief]
- [9]. Takano K, et al. Nucleic acid-induced resistance to viral infection. Journal of Bacteriology. 1965 Dec;90(6):1542-7. [Content Brief]
