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Results for "

insulin receptor substrate (IRS)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Insulin Receptor (5) Fluorescent Dye (1) Phosphatase (1) STAT (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (2) Metabolic Disease (2)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: Insulin Receptor MARCKS IGF-1R IDE

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-145935

NT219 1 Publications Verification	Insulin Receptor STAT	Cancer
NT219 is a potent and dual inhibitor of insulin receptor substrates 1/2 (IRS1/2) and STAT3. IRS1/2 and STAT3 are major signaling junctions regulated by various oncogenes. NT219 affects IRS1/2 degradation and inhibits STAT3 phosphorylation. NT219 has the potential for the research of cancer diseases .

HY-153479

Aganirsen	Insulin Receptor	Inflammation/Immunology
Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

HY-115461

MID-1	Insulin Receptor	Metabolic Disease
MID-1 is a disruptor of *MG53-IRS-1* (Mitsugumin 53-insulin receptor substrate-1) interaction. MID-1 disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake .

HY-P5433F

IRS-1 Peptide, FAM labeled	Insulin Receptor	Others
IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)

HY-153479A

Aganirsen sodium	Insulin Receptor	Inflammation/Immunology
Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

HY-162499

MY17	Phosphatase	Metabolic Disease
MY17 is an inhibitor of protein tyrosine phosphatase 1B (PTP1B) (IC₅₀=0.41±0.05 μM). MY17 alleviates palmitic acid (PA) -induced insulin resistance by up-regulating the expression of phosphorylated insulin receptor substrate (IRS1) and protein kinase B (AKT). By binding with PTP1B, MY17 can inhibit the activity of PTP1B, thereby improving insulin signaling and having anti-diabetic activity. MY17 can be used in the study of type 2 diabetes .

HY-179554

PtdIns-(4,5)-P2-fluorescein triethylammonium PI(4,5)P2-fluorescein triethylammonium	Fluorescent Dye	Others
PtdIns-(4,5)-P2-fluorescein (PI(4,5)P2-fluorescein) triethylammonium is a fluorescently labeled phosphatidylinositol-4,5-bisphosphate, which is a marked form of an important phospholipid signaling molecule (PIP2) on the cell membrane. PtdIns-(4,5)-P2-fluorescein triethylammonium can be used to detect proteins that interact with phosphatidylinositol-4,5-bisphosphate, such as PI3K, PTEN, and PH domain proteins, etc .

Cat. No.	Product Name	Target	Research Area

HY-P5433

IRS1-derived peptide	Peptides	Others
IRS1-derived peptide is a biological active peptide. (This is a peptide fragment (979-989) of the insulin receptor substrate-1 containing the sequence motif YMXM known to bind to the two domains of SH2 on the 85kDa subunit of phosphoinositide 3-kinase.)

HY-P5433F

IRS-1 Peptide, FAM labeled	Insulin Receptor	Others
IRS-1 Peptide, FAM labeled is a biological active peptide. (Insulin receptor substrate)

Species:	Human (2)
Tag:	His (1) Strep (1) GST (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702944

	IRS1 Protein, Human (GST) insulin receptor substrate 1; IRS-1	Human	E. coli
	IRS1 Protein, Human (GST) is the recombinant human-derived IRS1, expressed by E. coli , with GST labeled tag. ,

HY-P703573

	IRS1 Protein, Human (His, Strep) insulin receptor substrate 1; IRS1; Homo sapiens; Human; IRS-1; Transducer	Human	E. coli
	IRS1 Protein, Human (His, Strep) is the recombinant human-derived IRS1, expressed by E. coli , with Strep, His labeled tag. ,

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Host:	Rabbit (3)
Reactivity:	Human (3) Rat (3) Mouse (3)
Application:	IHC-P (3) ICC/IF (3) IP (1) IHC-F (1) WB (3) FC (1) ELISA (2)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Polyclonal (1) Monoclonal (2) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81116

	IRS-1 Antibody IRS1_HUMAN; insulin receptor substrate 1; IRS-1; IRS 1;	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	IRS-1 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IRS-1.

HY-P86121

	IRS-1 Antibody (YA5813) IRS1; insulin receptor substrate 1; IRS-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IRS-1 Antibody (YA5813) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRS-1.

HY-P82526

	IRS2 Antibody (YA2271) 1 Publications Verification insulin receptor substrate 2; IRS 2; IRS-2	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	IRS2 Antibody (YA2271) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IRS2.

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Cat. No.	Product Name		Classification

HY-153479

Aganirsen		Antisense Oligonucleotides
Aganirsen is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

HY-153479A

Aganirsen sodium		Antisense Oligonucleotides
Aganirsen sodium is a 25 mer DNA antisense oligonucleotide, which silences expression of insulin receptor substrate-1 (IRS-1).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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