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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
intestinal stem cells
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "intestinal stem cells" in MCE Product Catalog:
12
12 Publications Verification
Synonyms: Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
Target:
Liposome Endogenous Metabolite ACSL Family Amino acid Transporter Ferroptosis Glutathione Peroxidase
Research Areas:
DOPE (Dioleoylphosphatidylethanolamine; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine) is an orally active inhibitor of ferroptosis with anti-inflammatory and intestinal barrier maintenance activities. DOPE regulates the expression of ACSL4, SLC7A11 and GPX4 to restore the redox system balance, thereby reducing the levels of lipid peroxides, iron ions and intestinal inflammatory factors (IL-1β and IL-6). DOPE promotes the migration and proliferation of intestinal epithelial cells and increases the level of tight junction proteins; it also destabilizes endosomal membranes, mediates the conjugation of RVG peptides with mesenchymal stem cell-derived exosomes to enhance brain targeting. DOPE can be applied to research related to neonatal necrotizing enterocolitis and Alzheimer's disease .
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3
Target:
Research Areas:
CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease .
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2 Cited Publications
Cat. No.: HY-W250113
CAS No.: 58856-93-2
Synonyms: Zymosan A from Saccharomyces cerevisiae
1
1 Cited Publications
Cat. No.: HY-N1916
CAS No.: 63644-62-2
Target:
Cat. No.: HY-N13250
Cat. No.: HY-W094517
CAS No.: 7782-85-6
Cat. No.: HY-113286R
CAS No.: 463-00-3
Cat. No.: HY-163324A
Target:
Research Areas:
2-Me PeER is a rhodamine dye-based fluorescent probe that detects CYP3A4 activity. In fluorescence-activated cell sorting (FACS) based on CYP3A4 activity, homogeneous and functional human induced pluripotent stem cell (hiPSC)-derived hepatocytes and intestinal epithelial cells can be obtained with the aid of 2-Me PeER .
Cat. No.: HY-112005G
CAS No.: 4004-05-1
Synonyms: Dioleoylphosphatidylethanolamine (GMP); 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (GMP)
Cat. No.: HY-167182
CAS No.: 470695-03-5
Target:
Research Areas:
PUMAi is a PUMA inhibitor that disrupts the interaction between PUMA and BCL-xL. PUMAi inhibits apoptosis, caspase-3 activation, WNT/NOTCH pathway activation, and DNA damage. PUMAi protects intestinal tissues in mice, promotes the growth of colonoids, and reduces chemotherapy-induced weight loss, gastrointestinal damage, and lethality. PUMAi alleviates acetaminophen-induced liver injury and cytoplasmic translocation of HMGB1 in mice. PUMAi can be used in studies related to gastrointestinal injury, intestinal injury, and liver injury .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
