463-00-3
463-00-3
Chemical Structure
4-Guanidinobutanoic acid
- CAS No.: 463-00-3
- Formula:C5H11N3O2
- Molecular Weight:145.16
IUPAC Name: 4-guanidinobutanoic acid
InChIKey: TUHVEAJXIMEOSA-UHFFFAOYSA-N
SMILES: O=C(O)CCCNC(N)=N
Biological Activity: 4-Guanidinobutanoic acid is a metabolite of arginine and an orally active SLC36A1/Hedgehog signaling pathway activator. 4-Guanidinobutanoic acid drives epithelial reprogramming, enhances intestinal stem cell function and goblet cell differentiation. 4-Guanidinobutanoic acid promotes the enrichment of Akkermansia muciniphila via mucus-dependent niche expansion, regulates intestinal homeostasis, and establishes a microbiota-host feedback loop. 4-Guanidinobutanoic acid exhibits anti-aging and healthspan-regulating properties. 4-Guanidinobutanoic acid can be used in research related to ulcerative colitis, amyotrophic lateral sclerosis, and Duchenne muscular dystrophy[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4-Guanidinobutanoic acid | 98.0% | 4-Guanidinobutanoic acid is a metabolite of arginine and an orally active SLC36A1/Hedgehog signaling pathway activator. 4-Guanidinobutanoic acid drives epithelial reprogramming, enhances intestinal stem cell function and goblet cell differentiation. 4-Guanidinobutanoic acid promotes the enrichment of Akkermansia muciniphila via mucus-dependent niche expansion, regulates intestinal homeostasis, and establishes a microbiota-host feedback loop. 4-Guanidinobutanoic acid exhibits anti-aging and healthspan-regulating properties. 4-Guanidinobutanoic acid can be used in research related to ulcerative colitis, amyotrophic lateral sclerosis, and Duchenne muscular dystrophy. | ||||||||||||||||||||
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4-Guanidinobutanoic acid (Standard) | ≥98% | 4-Guanidinobutanoic acid (Standard) is the analytical standard of 4-Guanidinobutanoic acid (HY-113286). This product is intended for research and analytical applications. 4-Guanidinobutanoic acid is a metabolite of arginine and an orally active SLC36A1/Hedgehog signaling pathway activator. 4-Guanidinobutanoic acid drives epithelial reprogramming, enhances intestinal stem cell function and goblet cell differentiation. 4-Guanidinobutanoic acid promotes the enrichment of Akkermansia muciniphila via mucus-dependent niche expansion, regulates intestinal homeostasis, and establishes a microbiota-host feedback loop. 4-Guanidinobutanoic acid exhibits anti-aging and healthspan-regulating properties. 4-Guanidinobutanoic acid can be used in research related to ulcerative colitis, amyotrophic lateral sclerosis, and Duchenne muscular dystrophy. | ||||||||||||||||||||
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Argininic acid | 99.91% | Argininic acid is an α-amino acid that is used in the biosynthesis of proteins. | ||||||||||||||||||||
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2-Oxoarginine | 99.15% | 2-Oxoarginine (α-keto-δ-Guanidinovaleric acid) is an Arginine impurity. | ||||||||||||||||||||
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4-Guanidinobutanamide | 4-Guanidinobutanamide is a nucleoside metabolite. | |||||||||||||||||||||
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DL-Arginine (Standard) | ≥98% | DL-Arginine (Standard) is the analytical standard of DL-Arginine. This product is intended for research and analytical applications. DL-Arginine is the racemic compound of L-Arginine (HY-N0455) and D-Arginine (HY-W016781). Arginine is an essential amino acid that requires additional supplementation in traumatic or diseased conditions. Arginine is involved in T cell activation, proliferation, and differentiation, and affects the function of immune cells. | ||||||||||||||||||||
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L-Arginine-15N4 hydrochloride | 99.94% | L-Arginine-15N4 (hydrochloride) is the 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S)-(+)-Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis. | ||||||||||||||||||||
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L-Arginine (Standard) | 99.95% | L-Arginine (Standard) is the analytical standard of L-Arginine. This product is intended for research and analytical applications. L-Arginine ((S)-(+)-Arginine) is the substrate for the endothelial nitric oxide synthase (eNOS) to generate NO. L-Arginine is transported into vascular smooth muscle cells by the cationic amino acid transporter family of proteins where it is metabolized to nitric oxide (NO), polyamines, or L-proline. L-Arginine is a potent vasodilator, and can be used to induce experimental acute pancreatitis. | ||||||||||||||||||||
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Ompenaclid (Standard) | ≥98% | Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy. | ||||||||||||||||||||
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D-Arginine (Standard) | ≥98% | D-arginine (H-D-Arg-OH) is the D-isomer of arginine. Arginine is an α-amino acid that is used in the biosynthesis of proteins. D-Arginine is an inactive form of L-arginine. D-arginine can be used in myeloma and neurological disease research.. | ||||||||||||||||||||
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Glycocyamine | 99.96% | Glycocyamine (Guanidinoacetic acid) is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming. | ||||||||||||||||||||
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Glycocyamine-15N,13C2 | 97.40% | Glycocyamine-15N,13C2 (Guanidinoacetic acid-15N,13C2) is the 13C and 15N labeled Glycocyamine (HY-W021448). Clycocyamine is a direct precursor of creatine and an orally active energy metabolism regulator and myogenic differentiation inducer. Glycocyamine can activate the Akt/mTOR/S6K signaling pathway via miR-133a-3p and miR-1a-3p, and stimulate the mRNA expression of myogenic differentiation factor 1 (MyoD) and myopoietin (MyoG). Glycocyamine can increase muscle creatine concentration and maintain ATP homeostasis through the creatine phosphate/creatine kinase system. Glycocyamine can be used in research on feed additives for poultry farming. | ||||||||||||||||||||
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References
- [1]. Yang J, et al. A 4-guanidinobutanoic acid-SLC36A1 axis drives a microbiota‒host feedback loop to regulate intestinal homeostasis. Gut microbes. 2026 Dec 31;18(1):2639216. [Content Brief]
- [2]. Jonk SM, et al. Metabolic analysis of sarcopenic muscle identifies positive modulators of longevity and healthspan in C. elegans. Redox biology. 2025 Sep;85:103732. [Content Brief]
