223532-02-3
Chemical Structure
CPA inhibitor
Synonym(s): Carboxypeptidase inhibitor
- CAS No.: 223532-02-3
- Formula:C18H19NO4
- Molecular Weight:313.35
IUPAC Name: 2-benzyl-3-(N-hydroxy-2-phenylacetamido)propanoic acid
InChIKey: PONANXDRJJIGPG-UHFFFAOYSA-N
SMILES: O=C(N(CC(C(O)=O)CC1=CC=CC=C1)O)CC2=CC=CC=C2
Biological Activity: CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease[1][2].
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CPA inhibitor | 99.78% | CPA inhibitor (Compound 5) (Carboxypeptidase inhibitor) is an orally active competitive carboxypeptidase A (CPA) inhibitor with a Ki value of 0.32 μM. CPA inhibitor blocks the activity of carboxypeptidase A3 (CPA3). CPA activator activates the Wnt/Lrp6/β-catenin signaling pathway. CPA inhibitor reduces epithelial damage. CPA inhibitor is applicable to research related to inflammatory bowel disease, including ulcerative colitis and Crohn's disease. | ||||||||||||||||||||
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References
- [1]. Kim DH, et al. First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines. Bioorg Med Chem Lett. 1999;9(5):691-696. [Content Brief]
- [2]. Zhang T, et al. Mast Cells Inhibit Stem Cell-driven Epithelial Repair in Inflammatory Bowel Disease via Suppressing Wnt/lrp6/β-Catenin Signaling Pathway. Cell Mol Gastroenterol Hepatol. 2026;20(5):101741. [Content Brief]
