First hydroxamate inhibitors for carboxypeptidase A. N-acyl-N-hydroxy-beta-phenylalanines

  • Bioorg Med Chem Lett. 1999 Mar 8;9(5):691-6. doi: 10.1016/s0960-894x(99)00055-4.
D H Kim  1 ,  Y Jin
Affiliations
  • 1. Center for Biofunctional Molecules and Department of Chemistry, Pohang University of Science and Technology, Korea.
PMID: 10201830 DOI: 10.1016/s0960-894x(99)00055-4
Abstract

A series of N-acyl-N-hydroxy-beta-Phe were designed, synthesized, and shown to have potent inhibitory activity for Carboxypeptidase A (CPA). They are the first examples of CPA inhibitors having a hydroxamate functionality.

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