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Results for "

lactone metabolite

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32

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11

Natural
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3

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-41982
    D-Glucuronic acid lactone
    1 Publications Verification

    D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone

    		 Environmental Pollutants Endogenous Metabolite Drug Derivative Cardiovascular Disease Metabolic Disease
    D-Glucuronic acid lactone (D-Glucurono-6,3-lactone; D-Glucurono-γ-lactone; D-Glucuronolactone; Dicurone; Glucoxy; Glucurolactone; Glucurone) is an endogenous metabolite and a glucuronic acid derivative. D-Glucuronic acid lactone serves as a starting reagent for the synthesis of 2,3,4-tris (tert-butyldimethylsilyl) glucuronic acid trichloroethyl ester, which is used to prepare 1-O-acyl glucuronic acids for the anti-inflammatory agent mL-3000 (HY-B1452), synthesize optically active glucuronic acids, and produce long-chain alkyl glucuronides. D-Glucuronic acid lactone shows potential for use in studies of reversible cerebral vasoconstriction syndrome (RCVS) .
    D-Glucuronic acid lactone
  • HY-108549
    clasto-Lactacystin β-lactone

    Omuralide; β-Clastolactacystin

    		 Proteasome Cancer
    Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor.
    clasto-Lactacystin β-lactone
  • HY-125643
    Pitavastatin lactone

    		Drug Metabolite Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    Pitavastatin lactone is a major metabolite of Pitavastatin (HY-B0144A) in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase .
    Pitavastatin lactone
  • HY-101873
    Atorvastatin lactone

    		HMG-CoA Reductase (HMGCR) Drug Metabolite Neurological Disease
    Atorvastatin lactone is a myotoxic reagent and a metabolite of Atorvastatin acid, an HMG-CoA reductase inhibitor. Atorvastatin lactone exhibits myotoxicity .
    Atorvastatin lactone
  • HY-138166
    Rosuvastatin lactone

    		Drug Metabolite Metabolic Disease
    Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A) (HMG-CoA inhibitor) .
    Rosuvastatin lactone
  • HY-W008270
    2(5H)-Furanone

    γ-Crotonolactone

    		 Endogenous Metabolite Bacterial Infection Neurological Disease
    2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures.
    2(5H)-Furanone
  • HY-135700
    Mevalonolactone

    		Calcineurin Ras HMG-CoA Reductase (HMGCR) Metabolic Disease Inflammation/Immunology
    Mevalonolactone is an intermediate metabolite in the eukaryotic mevalonate pathway, serving as the stable δ-lactone form of mevalonate with oral activity. Mevalonolactone exhibits binding affinity for ZNF384 (Ka = 12.6 μM) and inhibitory activity against aconitase (aconitase). Mevalonolactone promotes the nuclear localization of ZNF384 and enhances its binding to the GGPPS promoter. Mevalonolactone induces insulin resistance, disrupts glucose and lipid metabolism, enhances the isoprenylation of K-Ras, and inhibits the activation of the insulin signaling pathway. Mevalonolactone inhibits polypeptide synthesis of HMG-CoA reductase in isolated rat hepatocytes, promotes its degradation, and reduces its enzymatic activity. Mevalonolactone impairs mitochondrial function in rat brains. Mevalonolactone promotes the development of metabolically unhealthy obesity. Mevalonolactone can be used in research related to metabolically abnormal obesity, mevalonic aciduria, HMGCR-related limb-girdle myopathy, and statin-induced myopathy .
    Mevalonolactone
  • HY-135235
    Cysteine thiol probe
    1 Publications Verification

    		 Fluorescent Dye Others
    Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites .
    Cysteine thiol probe
  • HY-121795
    Pravastatin lactone

    		HMG-CoA Reductase (HMGCR) Cardiovascular Disease
    Pravastatin lactone is a potent HMG-CoA inhibitor. Pravastatin Lactone is a metabolite of pravastatin. Pravastatin lactone reduces blood cholesterol levels by inhibiting cholesterol synthesis .
    Pravastatin lactone
  • HY-W017445
    Homogentisic acid lactone

    		Fungal Infection
    Homogentisic acid lactone (Compound 1) is a fungal metabolite with fungicidal activity, which is found in the fungus WF5. Homogentisic acid lactone is active against the plant pathogenic fungus F. graminearum. Homogentisic acid lactone can be used as a substrate in the determination of serum paraoxonase/arylesterase 1 (PON1) activity .
    Homogentisic acid lactone
  • HY-136410
    4-hydroxy Nonenal Mercapturic Acid

    		Endogenous Metabolite Metabolic Disease
    4-hydroxy Nonenal Mercapturic Acid is a major urinary metabolite of 4-hydroxy-2-nonenal (4-HNE). 4-hydroxy Nonenal Mercapturic Acid metabolites include reduced alcohols, aldehydes, and carboxylic acids, which further form gamma-lactols and gamma-lactones, resulting in 4-5 final urinary metabolites in vivo. 4-hydroxy Nonenal Mercapturic Acid can be used as a biomarker to assess oxidative stress .
    4-hydroxy Nonenal Mercapturic Acid
  • HY-133879
    Calcitriol lactone

    1α,25-Dihydroxyvitamin D3-26,23-lactone

    		 Endogenous Metabolite Others Inflammation/Immunology
    Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function .
    Calcitriol lactone
  • HY-116246
    5(S)-HETE lactone

    		Drug Metabolite Inflammation/Immunology
    5(S)-HETE lactone is an arachidonic acid (AA) metabolite .
    5(S)-HETE lactone
  • HY-176301
    Tetranor-PGDM lactone

    Tetranor-prostaglandin D metabolite lactone

    		 Endogenous Metabolite Inflammation/Immunology Endocrinology
    Tetranor-PGDM lactone (Tetranor-prostaglandin D metabolite lactone) is a urinary metabolite of PGD2 (HY-101988). Prostaglandin D2 (PGD2) is one of the most potent endogenous sleep promoting substances. PGD2 plays a protective role by suppressing inflammation .
    Tetranor-PGDM lactone
  • HY-135394
    3-Desacetyl Cefotaxime lactone

    		Drug Metabolite Antibiotic Infection
    3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
    3-Desacetyl Cefotaxime lactone
  • HY-41982R
    D-Glucuronic acid lactone (Standard)

    D-Glucurono-6,3-lactone (Standard); D-Glucurono-γ-lactone (Standard); D-Glucuronolactone (Standard); Dicurone (Standard); Glucoxy (Standard); Glucurolactone (Standard); Glucurone (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    D-Glucuronic acid lactone (Standard) is the analytical standard of D-Glucuronic acid lactone. This product is intended for research and analytical applications. D-Glucuronic acid lactone is an endogenous metabolite.
    D-Glucuronic acid lactone (Standard)
  • HY-136346S
    Ortho-hydroxy atorvastatin lactone-d5

    		Drug Metabolite Cardiovascular Disease
    Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
    Ortho-hydroxy atorvastatin lactone-d5
  • HY-130220
    (±)5-HETE lactone

    		Drug Isomer Inflammation/Immunology
    (±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation .
    (±)5-HETE lactone
  • HY-135394R
    3-Desacetyl Cefotaxime lactone (Standard)

    		Reference Standards Drug Metabolite Antibiotic Infection
    3-Desacetyl Cefotaxime lactone (Standard) is the analytical standard of 3-Desacetyl Cefotaxime lactone. This product is intended for research and analytical applications. 3-Desacetyl Cefotaxime lactone is the active metabolite of Cefotaxime. Cefotaxime sodium salt is a third-generation cephalosporin antibiotic.
    3-Desacetyl Cefotaxime lactone (Standard)
  • HY-127142
    Cephapirin lactone

    		Endogenous Metabolite Others
    Cephapirin lactone is a Metabolite of antibiotic Cephapirin (HY-A0153) .
    Cephapirin lactone
  • HY-119328
    Pestalotin

    		Endogenous Metabolite Others
    Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .
    Pestalotin
  • HY-138166S
    Rosuvastatin lactone-d6

    		Isotope-Labeled Compounds Potassium Channel Drug Metabolite NO Synthase Cardiovascular Disease
    Rosuvastatin lactone-d6 is the deuterium labeled Rosuvastatin lactone. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .
    Rosuvastatin lactone-d6
  • HY-138166R
    Rosuvastatin lactone (Standard)

    		Reference Standards Potassium Channel Drug Metabolite NO Synthase Cardiovascular Disease
    Rosuvastatin lactone (Standard) is the analytical standard of Rosuvastatin lactone. This product is intended for research and analytical applications. Rosuvastatin lactone is a metabolite of Rosuvastatin (HY-17504A), a statin lipid-lowering agent and HMG-CoA inhibitor. Rosuvastatin lactone exhibits endothelium-independent and HMG-CoA reductase-independent vasorelaxant activity in rat aortic rings, and its vasorelaxant effect is jointly mediated by NO produced by inducible nitric oxide synthase (iNOS) located in vascular smooth muscle and activation of potassium channels. Rosuvastatin lactone itself has no lipid-lowering effect .
    Rosuvastatin lactone (Standard)
  • HY-136346
    2-Hydroxy atorvastatin lactone

    		Drug Metabolite Cardiovascular Disease
    2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
    2-Hydroxy atorvastatin lactone
  • HY-126852
    4-Hydroxy Atorvastatin lactone

    P-Hydroxyatorvastatin lactone; 4-ATL

    		 Drug Metabolite Metabolic Disease Inflammation/Immunology
    4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
    4-Hydroxy Atorvastatin lactone
  • HY-N10269
    Phomalactone

    		Fungal Endogenous Metabolite Infection
    Phomalactone, produced by the fungus Nigrospora sphaerica, specifically inhibits the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg/L . Phomalactone is phytotoxic to Z. elegans and other plant species by inhibition of seedling growth and by causing electrolyte leakage from photosynthetic tissues of both Z. elegans leaves and cucumber cotyledons .
    Phomalactone
  • HY-N10192
    Aculene D

    		Endogenous Metabolite Bacterial Infection
    Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .
    Aculene D
  • HY-119695AS
    Simvastatin acid-d6 ammonium

    Tenivastatin-d6 ammonium

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene .
    Simvastatin acid-d6 ammonium
  • HY-W008270R
    2(5H)-Furanone (Standard)

    γ-Crotonolactone (Standard)

    		 Reference Standards Endogenous Metabolite Others
    2(5H)-Furanone (Standard) is the analytical standard of 2(5H)-Furanone. This product is intended for research and analytical applications. 2(5H)-Furanone (γ-Crotonolactone) is an endogenous metabolite. 2(5H)-Furanone mimics N-acyl homoserine lactone signals, occupies the binding site of LuxR homologs, and interferes with quorum sensing-mediated gene regulation. 2(5H)-Furanone inhibits quorum sensing mediated by AHLs with different acyl chain lengths. 2(5H)-Furanone inhibits biofilm formation of environmental Aeromonas hydrophila strains on polystyrene plates. 2(5H)-Furanone suppresses spike-and-wave discharges in a rat model of generalized absence seizures and exhibits selective activity against absence seizures. 2(5H)-Furanone can be used in studies related to bacteria infections and generalized absence seizures.
    2(5H)-Furanone (Standard)
  • HY-W746889
    17-Phenyl trinor prostaglandin F2α 1,15-lactone

    17-Phenyl trinor PGF2α 1,15-lactone

    		 Drug Derivative Others
    17-Phenyl trinor prostaglandin F2α 1,15-lactone (17-Phenyl trinor PGF2α 1,15-lactone) is a 1,15 lactone of 17-Phenyl trinor prostaglandin F2α. 17-Phenyl trinor prostaglandin F2α is a metabolite of Dinoprost (HY-12956) .
    17-Phenyl trinor prostaglandin F2α 1,15-lactone
  • HY-129443
    Deacetylcephaloglycin

    		Drug Metabolite Others
    Deacetylcephaloglycin is the active metabolite of Cephaloglycin (HY-16137). Deacetylcephaloglycin is a degradation product of Cephaloglycin that eliminates the 3-acetyl group in acidic medium and can be further degraded to Deacetylcephaloglycin lactone. Deacetylation is the rate-determining step in the degradation of Cephaloglycin to lactone .
    Deacetylcephaloglycin
  • HY-N16977
    6β,8-Dihydroxyeremophil-7(11)-en-12,8-olide

    		Others Others
    6β,8-Dihydroxyeremophil-7(11)-en-12,8-olide is an eremophilane-type sesquiterpene lactone compound, and eremophilane-type sesquiterpenes are the main secondary metabolites of Ligularia genus plants. 6β,8-Dihydroxyeremophil-7(11)-en-12,8-olide can be naturally extracted from the dried roots of Ligularia virgaurea (Maxim.) Mattf .
    6β,8-Dihydroxyeremophil-7(11)-en-12,8-olide

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