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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
94 Results for "
metalloprotease
" in MedChemExpress (MCE) Product Catalog:
Products (94)
94 Results for "metalloprotease" in MCE Product Catalog:
67
67 Publications Verification
Synonyms: GM6001; Galardin
Ilomastat (GM6001) is a potent and broad spectrum matrix metalloprotease (MMP) inhibitor, inhibits MMPs (IC50s, 1.5 nM for MMP-1; 1.1 nM for MMP-2; 1.9 nM for MMP-3; 0.5 nM for MMP-9), with a Ki of 0.4 nM for human skin fibroblast collagenase (MMP-1).
43
43 Cited Publications
Cat. No.: HY-N0431
CAS No.: 84687-43-4
7
7 Cited Publications
Target:
Research Areas:
UK 356618 (Compound 4j) is a potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) with an IC50 of 5.9 nM. UK 356618 is less potent against MMP-1, MMP-2, MMP-9, MMP-13 and MMP-14 compared with MMP-3 .
5
5 Cited Publications
Synonyms: TNF Protease Inhibitor 2
TAPI-2 (TNF Protease Inhibitor 2) is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20 μM for MMP . TAPI-2 blocks the entry of infectious SARS-CoV .
2
Research Areas:
Omapatrilat is a dual inhibitor of the metalloproteases ACE and NEP with Ki values of 0.64 and 0.45 nM, respectively.
2
2 Cited Publications
Target:
Research Areas:
6bK TFA is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK TFA binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK TFA improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK TFA can be used in research related to type 2 diabetes .
2
2 Cited Publications
Cat. No.: HY-P7441
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACE2; Angiotensin I Converting Enzyme 2; Angiotensin Converting Enzyme 2; Angiotensin-Converting Enzyme 2; ACEH; ACE-Related Carboxypeptidase; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2; metalloprotease MPROT15; Angiotensin-Converting Enzy
Species:
Human
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P81193
Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 5; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5; A Disintigrin And Metalloproteinase with ThromboSpondin motif-5; ADAM metallopeptidase with thrombospondin type 1 motif 5; ADAM TS 11; ADAM TS 5; ADAM TS5; ADAMTS 11; ADAMTS 5; ADAMTS11; ADMP 2; ADMP2; Aggrecanase 2; aggrecanase-2; FLJ36738; Implantin; ThromboSpondin motif-5.
1
1 Cited Publications
Target:
Research Areas:
NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .
1
1 Cited Publications
Cat. No.: HY-162284
CAS No.: 3032487-31-0
Target:
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BAY-9835, a chemical probe, is an orally active ADAMTS7 and ADAMTS12 antagonist with IC50s of 6 nM and 30 nM, respectively. BAY-9835 exhibits inhibitory potencies vs mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the study of atherogenesis .
1
1 Cited Publications
Cat. No.: HY-13545
CAS No.: 251579-55-2
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P3722
CAS No.: 192723-42-5
Target:
Research Areas:
1
1 Cited Publications
Cat. No.: HY-P70250
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: MMP1; Matrix Metallopeptidase 1 (Interstitial Collagenase); Prev. CLG; Matrix Metalloproteinase 1; Interstitial Collagenase; Matrix metalloprotease 1; Fibroblast Collagenase; Alternative Protein MMP1; Matrix Metalloproteinase 1 (Interstitial Collagenase); MMP-1; Matrix Metallopeptidase 1; Matrix Metalloproteinase-1
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7442
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ACE2; Angiotensin I Converting Enzyme 2; Angiotensin Converting Enzyme 2; Angiotensin-Converting Enzyme 2; ACEH; ACE-Related Carboxypeptidase; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2; metalloprotease MPROT15; Angiotensin-Converting Enzy
Species:
Human
Source:
HEK293
1
1 Cited Publications
Cat. No.: HY-P7443
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ACE2; Angiotensin I Converting Enzyme 2; Angiotensin Converting Enzyme 2; Angiotensin-Converting Enzyme 2; ACEH; ACE-Related Carboxypeptidase; Angiotensin I Converting Enzyme (Peptidyl-Dipeptidase A) 2; metalloprotease MPROT15; Angiotensin-Converting Enzy
Species:
Human
Source:
HEK293
Cat. No.: HY-N2021A
CAS No.: 164204-38-0
Cat. No.: HY-E70196
CAS No.: 55576-49-3
Synonyms: Asp-N
Target:
Research Areas:
Endoproteinase Asp-N (MS grade) is a metalloprotease that can specifically cleave the N-terminal side of aspartyl and cysteic acid residues .
Cat. No.: HY-E70562
Mucinase StcE is a zinc metalloproteinase belonging to the M66 family, which is secreted by enterohemorrhagic Escherichia coli via the type II general secretion pathway. Mucinase StcE specifically recognizes and cleaves the 'T*XT' motif in mucin-type glycoproteins with α-O-glycans (such as MUC2, Mucin 7, Glycoprotein 340, CD45, CD43, C1 Esterase Inhibitor (HY-P991629), etc.). By degrading the mucus layer to reduce its viscosity, inhibiting complement cascade activation, and localizing complement regulatory factors to the cell membrane, Mucinase StcE helps bacteria penetrate the mucosal barrier, adhere to host cells, and evade immune clearance. Mucinase StcE can serve as a mucin-specific proteolytic tool for research on mucinous carcinomas derived from the colon, esophagus, and salivary glands .
Research Areas:
ADAMTS-5-IN-2 is an inhibitor of ADAMTS-5 (IC50: 9.6 μM) and BoNT/A LC (IC50: 0.71 μM). ADAMTS-5-IN-2 can be used in research related to botulism, osteoarthritis, and other conditions .
Cat. No.: HY-P2980
CAS No.: 11075-17-5
Synonyms: EC 3.4.2.1
Target:
Research Areas:
Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
