18 Results for "

nonribosomal peptide

" in MedChemExpress (MCE) Product Catalog:
Products (18)

18 Results for "nonribosomal peptide" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-112862
CAS No.: 301351-95-1
Purity:  ≥98.0%
Research Areas:  

Infection

Arg-AMS (compound 24) is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes .
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Cat. No.: HY-160238
CAS No.: 95536-41-7
Synonyms: Corynebactin
Bacillibactin (Corynebactin) is a cyclic tricatecholate siderophore. Bacillibactin’s primary function is to facilitate bacterial iron acquisition by chelating iron ions (Fe 3+) from the environment, thereby aiding bacterial survival under iron-limited conditions. Bacillibactin exhibits direct antimicrobial activity, such as inhibition of the growth of the producing bacteria Pseudomonas aeruginosa and Aeromonas veronae, as well as plant pathogens such as Pseudomonas syringae.Bacillibactin can be used in antibacterial and antifungal research .
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Cat. No.: HY-P1680
CAS No.: 148057-23-2
Synonyms: Asterin
Astin C (Asterin) is a cyclopeptide that can be extracted from Aster tataricus. Astin C has anti-inflammatory and anti-cancer activities. Astin C can specifically inhibit the cGAS-STING signaling pathway, block the recruitment of IRF3 to the STING signalosome, and thus inhibit the innate inflammatory response. Astin C can be used in the research of autoimmune diseases and cancers .
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Cat. No.: HY-W142073
CAS No.: 17332-70-6
Synonyms: 7-Methyltryptophan
Research Areas:  

Infection

7-Methyl-DL-tryptophan (7-Methyltryptophan) is an amino acid derivative, which is a key precursor for biosynthesis of many non-ribosomal peptide antibiotics. 7-Methyl-DL-tryptophan plays an important role in synthesis of high-efficiency antibacterial agents and analogues thereof .
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Cat. No.: HY-W073762
CAS No.: 2241669-86-1
Research Areas:  

Cancer

FBnG is a component of non-ribosomal peptide synthetase/polyketide synthase (NRPS/PKS), which is associated with the biosynthesis of fabrubactin (FBN). FBnG can be used for synthesis of AUTAC4 as part of FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 (HY-150408) .
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Cat. No.: HY-100710
CAS No.: 186692-73-9
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

Epothilone C is a polyketide natural product. Epothilone C is produced by the combined action of one nonribosomal peptide synthetase (NRPS) and nine polyketide synthase (PKS) modules in a multienzyme system. Epothilone C can be used for tumor research .
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Cat. No.: HY-P5707
CAS No.: 4422-52-0
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Gramicidin B is a nonribosomal peptide antibiotic .
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Cat. No.: HY-162371
Research Areas:  

Infection

NRPSs-IN-1 (Compound 7) is a cell-penetrating inhibitor of non-ribosomal peptide synthetase (NRPSs). NRPSs-IN-1 K inhibits gramicidin S synthetase A (GrsA) with a Kd value of 16.6 nM .
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Cat. No.: HY-121459
CAS No.: 22862-63-1
Target:  

HSP Ras

Neoantimycin is a GRP78/BiP and K-Ras regulator with anticancer activity. Its biosynthesis is catalyzed by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) system .
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Cat. No.: HY-130043
CAS No.: 956904-34-0
11-O-Methylpseurotin A is a compound of mixed polyketide synthase–nonribosomal peptide synthetase (PKS/NRPS) origin. 11-O-Methylpseurotin A selectively inhibits a Hof1 deletion strain .
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Cat. No.: HY-153859
CAS No.: 322650-05-5
Research Areas:  

Others

Ser-SNAC TFA is a small-molecule substrate for NRPS C domains. As for NRPSs, refers to nonribosomal peptide synthetases, are large multidomain proteins to catalyze the formation of biologically active natural products. Ser-SNAC TFA can be used for characterizing the substrate specificity of C domain-catalyzed peptide bond formation .
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Cat. No.: HY-P11040
Target:  

Bacterial Antibiotic

Research Areas:  

Infection

Peptide P2.2, a non-ribosomal peptide, is an antimicrobial peptide. Peptide P2.2 has potent antibacterial activity with MIC50s of 4 and 32 μM for V. parahaemolyticus and V. alginolyticus, respectively. Peptide P2.2 increases synergistic antibacterial effects with antibiotics (such as Ofloxacin (HY-B0125) and Linezolid (HY-10394)) with negligible hemolytic activity. Peptide P2.2 disrupts bacterial membranes and increases permeability by modulating proteins involved in the type VI and III secretion systems. Peptide P2.2 can be used for bacterial infections research .
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Cat. No.: HY-137502
CAS No.: 1542213-67-1
Target:  

Bacterial

Research Areas:  

Infection

ML267 is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections .
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Cat. No.: HY-N13942
CAS No.: 444300-73-6
Target:  

Others

Argyrin E is a natural cyclic, non-ribosomal peptide .
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Cat. No.: HY-N13945
CAS No.: 444300-75-8
Target:  

Others

Argyrin G is a natural cyclic, non-ribosomal peptide .
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Cat. No.: HY-N13948
CAS No.: 444300-76-9
Target:  

Others

Argyrin H is a natural cyclic, non-ribosomal peptide .
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Cat. No.: HY-W722245
CAS No.: 79236-62-7
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe 3+ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn 2+, Co 2+, and Ni 2+, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .
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Cat. No.: HY-137502A
CAS No.: 1542213-03-5
Target:  

Bacterial

Research Areas:  

Infection

ML267 free base is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 free base attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 free base inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 free base is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections .
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