79236-62-7
Chemical Structure
Pyochelin
- CAS No.: 79236-62-7
- Formula:C14H16N2O3S2
- Molecular Weight:324.42
InChIKey: NYBZAGXTZXPYND-GBIKHYSHSA-N
SMILES: OC1=C(C=CC=C1)C2=N[C@]([H])(CS2)[C@@]3(N([C@@H](CS3)C(O)=O)C)[H]
Biological Activity: Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe3+ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn2+, Co2+, and Ni2+, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection[1][2][3].
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Pyochelin | Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe3+ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn2+, Co2+, and Ni2+, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection. | |||||||||||||||||||||
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[1]. Ghssein G, Ezzeddine Z. A Review of Pseudomonas aeruginosa Metallophores: Pyoverdine, Pyochelin and Pseudopaline. Biology (Basel). 2022 Nov 25;11(12):1711.
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[2]. Ma X, et al. Relationship between Pyochelin and Pseudomonas Quinolone Signal in Pseudomonas aeruginosa: A Direction for Future Research. Int J Mol Sci. 2024 Aug 7;25(16):8611.
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[3]. Mangal S, et al. In vivo efficacy of pyochelin-mediated delivery of zingerone in Pseudomonas aeruginosa-induced peritonitis. Future Microbiol. 2023 Dec;18:1339-1351.
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Keywords
