89 Results for "

osteoclastogenesis

" in MedChemExpress (MCE) Product Catalog:

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Omaveloxolone

26 Publications Verification

Cat. No.: HY-12212

CAS No.: 1474034-05-3

Purity: 99.38%

Synonyms: RTA 408

Target:

Keap1-Nrf2 STING Apoptosis

Research Areas:

Inflammation/Immunology Cancer

Omaveloxolone (RTA 408) is an antioxidant inflammation modulator (AIM), which activates Nrf2 and suppresses nitric oxide (NO). Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.

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4-IPP

11 Cited Publications

Cat. No.: HY-110063

CAS No.: 41270-96-6

Purity: 99.46%

Synonyms: 4-Iodo-6-phenylpyrimidine

Target:

Macrophage migration inhibitory factor (MIF)

Research Areas:

Metabolic Disease

4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) .

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Sappanone A

8 Cited Publications

Cat. No.: HY-113556

CAS No.: 102067-84-5

Purity: 99.87%

Category:

Flavonoids Leguminosae Caesalpinia sappan L. Plants Disease Research Fields Inflammation/Immunology Isoflavones

Target:

Phosphodiesterase (PDE) NF-κB Keap1-Nrf2 Reactive Oxygen Species (ROS) TNF Receptor Nuclear Factor of activated T Cells (NFAT) Akt ERK p38 MAPK NO Synthase Interleukin Related COX JNK

Sappanone A is an orally active homoisoflavone found in sappan L. Sappanone A is a PDE4 and NF-κB inhibitor with anti-inflammatory and antioxidant effect. Sappanone A induces HO-1 expression through activation of Nrf2 pathway. Sappanone A also inhibits RANKL-induced osteoclastogenesis. Sappanone A has great potential in the research of inflammation-related and cardiovascular .

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Isobavachin

6 Cited Publications

Cat. No.: HY-N0762

CAS No.: 31524-62-6

Category:

Flavonoids Neurological Disease Leguminosae Flavonones Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields

Target:

Cytochrome P450 UGT p38 MAPK NF-κB NO Synthase COX Fc Receptor (FcR) RANKL/RANK Keap1-Nrf2 Reactive Oxygen Species (ROS) Apoptosis Autophagy

Isobavachin is an orally active, blood-brain barrier-penetrating prenylated flavonoid present in Psoralea corylifolia. Isobavachin inhibits human CYP2B6, CYP2C9, CYP2C19, UGT1A1, UGT1A9, and UGT2B7. Isobavachin suppresses MAPK activation, NF-κB nuclear translocation, overexpression of iNOS/COX-2, FcεRI-mediated signaling pathways, and RANKL-induced osteoclastogenesis. Isobavachin induces autophagy, cytotoxicity, neuronal differentiation, and NRF2 activation; it alleviates oxidative damage, inflammatory responses, apoptosis, iron accumulation, mitochondrial biogenesis, and mast cell degranulation. Isobavachin is applicable to research related to liver injury, inflammatory diseases, osteoporosis, liver cancer, prostate cancer, glioma, periodontitis-induced bone loss, and Alzheimer's disease .

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Epimedin A

4 Cited Publications

Cat. No.: HY-N0257

CAS No.: 110623-72-8

Category:

Flavonols Flavonoids Monophenols Other Diseases Phenols Epimedium brevicornu Maxim. Plants Berberidaceae Disease Research Fields

Target:

PI3K Akt NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Heme Oxygenase (HO) SOD Caspase Interleukin Related

Epimedin A, one of the main flavonoid active components in Herba Epimedii, is orally active. Epimedin A can inhibit osteoclastogenesis, differentiation, and bone resorption. Epimedin A also possesses anti-inflammatory activity. Epimedin A can be used in the research of osteoporosis and inflammatory diseases .

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Sciadopitysin

4 Cited Publications

Cat. No.: HY-N2119

CAS No.: 521-34-6

Category:

Flavonoids Ginkgoaceae Phenols Polyphenols Plants Disease Research Fields Inflammation/Immunology Ginkgo biloba Biflavones

Target:

TNF Receptor NF-κB

Sciadopitysin is a type of biflavonoids in leaves from ginkgo biloba . Sciadopitysi inhibits RANKL-induced osteoclastogenesis and bone loss by inhibiting NF-κB activation and reducing the expression of c-Fos and NFATc1 .

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NFATc1-IN-1

4 Cited Publications

Cat. No.: HY-147369

CAS No.: 1912422-56-0

Purity: 99.97%

Target:

Nuclear Factor of activated T Cells (NFAT)

Research Areas:

Others

NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC₅₀ of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .

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VUF11207 fumarate

3 Cited Publications

Cat. No.: HY-110318

CAS No.: 1785665-61-3

Purity: 98.28%

Target:

CXCR

Research Areas:

Inflammation/Immunology Cancer

VUF11207 fumarate is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation .

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Vaccarin

2 Cited Publications

Cat. No.: HY-N1419

CAS No.: 53452-16-7

Category:

other families Flavonoids Flavones Metabolic Disease Phenols Polyphenols Plants Disease Research Fields

Target:

AMPK Akt ERK p38 MAPK NF-κB Nuclear Factor of activated T Cells (NFAT) JNK

Vaccarin is an orally active flavonoid glycoside with multiple biological functions. Vaccarin promotes neovascularization by activating AKT and ERK. Vaccarin activates the AMPK signaling pathway to improve insulin resistance and steatosis. Vaccarin is a MAPK, NF-κB, and NFAT inhibitor, effectively blocking RANKL-induced osteoclastogenesis .

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Bavachalcone

2 Cited Publications

Cat. No.: HY-N0231

CAS No.: 28448-85-3

Synonyms: Broussochalcone B

Category:

Infection Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields

Target:

Bacterial Antibiotic NF-κB PERK Akt Autophagy Apoptosis

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro .

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Methylnissolin

2 Cited Publications

Cat. No.: HY-N2484

CAS No.: 73340-41-7

Synonyms: Astrapterocarpan

Category:

Cardiovascular Disease Flavonoids Monophenols Leguminosae Astragalus membranaceus var. mongholicus (Bunge)P.K.Hsiao Phenols Plants Disease Research Fields Other Flavonoids

Target:

PDGFR ERK

Methylnissolin (Astrapterocarpan) is an osteoclast inhibitor with anti-inflammatory, neuroprotective and antioxidant activities. Methylnissolin downregulates the activation of the MAPK and PI3K/AKT pathways, inhibits the phosphorylation of MAPK1 and AKT1, and blocks PDGF-BB-induced phosphorylation of ERK1/2. Methylnissolin reduces the expression and secretion of proinflammatory mediators, decreases intracellular ROS levels, upregulates antioxidant enzymes, and downregulates osteoclastogenesis markers. Methylnissolin is applicable to research related to ischemic stroke, osteoporosis, cardiovascular diseases, skin aging, etc.

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TNFRSF11B/OPG Protein, Human (HEK293, His)

2 Cited Publications

Cat. No.: HY-P70805

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: Tumor Necrosis Factor Receptor Superfamily Member 11B; osteoclastogenesis Inhibitory Factor; Osteoprotegerin; TNFRSF11B; OCIF; OPG

Species:

Human

Source:

HEK293

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TNFRSF11B/OPG Protein, Mouse (HEK293, His)

2 Cited Publications

Cat. No.: HY-P71017

Purity: ≥ 95%, as determined by reducing SDS-PAGE.

Synonyms: Tumor necrosis factor receptor superfamily member 11B; osteoclastogenesis inhibitory factor; Osteoprotegerin; Tnfrsf11b; Ocif; Opg

Species:

Mouse

Source:

HEK293

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Rhoifolin

1 Cited Publications

Cat. No.: HY-N0755

CAS No.: 17306-46-6

Category:

Rhus succedanea Flavonoids Flavones Plants Disease Research Fields Endocrinology Cancer Anacardiaceae

Target:

Insulin Receptor GLUT NF-κB p38 MAPK Autophagy

Rhoifolin is a flavone glycoside can be isolated from Rhus succedanea. Rhoifolin has anti-diabetic effect acting through enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and glucose transporter 4 (GLUT 4) translocation. Rhoifolin has an anti-inflammatory action via multi-level regulation of inflammatory mediators. Rhoifolin ameliorates titanium particle-stimulated osteolysis and attenuates osteoclastogenesis via RANKL-induced NF-κB and MAPK pathways. Rhoifolin also has cytotoxic activity against different cancer cell lines .

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Roburic acid

1 Cited Publications

Cat. No.: HY-N0481

CAS No.: 6812-81-3

Category:

Gentiana macrophylla Pall. Triterpenes Terpenoids Gentianaceae Plants Disease Research Fields Inflammation/Immunology

Target:

COX TNF Receptor NO Synthase Interleukin Related NF-κB Apoptosis p38 MAPK JNK ERK Keap1-Nrf2 RANKL/RANK

Roburic acid acts as an anti-inflammatory, anti-tumor and osteoclastogenesis inhibitor, with a K_i of 7.066 μM against human TNF, an IC₅₀ of 9 μM against human COX-2, and an IC₅₀ of 5 μM against ovine COX-1. Roburic acid reduces the production of inflammatory mediators such as NO and IL-6 in macrophages by inhibiting the NF-κB and MAPK (p38/JNK) pathways. By competitively inhibiting the TNF-TNF-R1 interaction, Roburic acid blocks the downstream NF-κB signaling pathway, thereby inducing cell cycle arrest and apoptosis in cancer cells. Roburic acid specifically inhibits osteoclastogenesis and bone resorption by suppressing the RANKL/TRAF6/NF-κB/NFATc1 axis. Roburic acid can be used in research related to osteolytic diseases such as osteoporosis, colorectal cancer and inflammatory diseases .

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Neomangiferin

1 Cited Publications

Cat. No.: HY-N0723

CAS No.: 64809-67-2

Category:

Liliaceae Xanthones Metabolic Disease Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants Disease Research Fields

Target:

Autophagy p38 MAPK TNF Receptor Interleukin Related PPAR

Neomangiferin is an orally active natural flavonoid. Neomangiferin partially ameliorates non-alcoholic fatty liver disease (NAFLD) by regulating the expression of genes related to free fatty acid uptake and lipid oxidation. Neomangiferin exerts anti-colitis effects by inhibiting Th17/Treg cell differentiation. Neomangiferin exerts anti-aging and lifespan-extending effects by targeting upregulation of bas-1, which in turn activates the autophagy, IIS and MAPK pathways. Neomangiferin has the potential to prevent aseptic loosening of prostheses after total joint arthroplasty due to its significant anti-inflammatory and osteoclastogenesis-inhibiting effects .

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Pteryxin

1 Cited Publications

Cat. No.: HY-N2157

CAS No.: 13161-75-6

Synonyms: (+)-Pteryxin

Category:

Coumarins Phenylpropanoids Plants Umbelliferae Achillea atrata L.

Target:

Cholinesterase (ChE) NF-κB NOD-like Receptor (NLR) Keap1-Nrf2 Reactive Oxygen Species (ROS) Nuclear Factor of activated T Cells (NFAT) p38 MAPK

Pteryxin ((+)-Pteryxin) is an orally active multi-target inhibitor that targets NF-κB, MAPK, NLRP3 inflammasome, and Nrf2/ARE pathways. Pteryxin is also a BChE inhibitor (IC₅₀=12.96 μg/mL) with a low inhibitory efficiency on AChE. Pteryxin inhibits the Ca ²⁺-calcineurin-NFATc1 pathway by blocking NF-κB/MAPK signaling, inhibiting NLRP3 inflammasome activation, and reducing ROS generation, and activates Nrf2-mediated antioxidant enzyme expression. Pteryxin has anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin can be used in the study of inflammatory diseases, osteoporosis, diabetes, and Alzheimer's disease .

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Orcinol glucoside

1 Cited Publications

Cat. No.: HY-N0008

CAS No.: 21082-33-7

Category:

Curculigo orchioides Gaertn. Monophenols Phenols Plants Amaryllidaceae

Target:

Wnt p38 MAPK mTOR Keap1-Nrf2 TGF-β Receptor

Orcinol glucoside is an orally active, blood-brain barrier permeable osteoblast proliferation promoter that targets the Nrf2/Keap1, mTOR and p38 signaling pathways. Orcinol glucoside promotes Nrf2 nuclear translocation, upregulates antioxidant enzyme levels, enhances the phosphorylation of mTOR and p70S6K, and inhibits the enzymatic activity of HAS2 as well as the nuclear translocation of GR. Orcinol glucoside also alleviates oxidative stress, inhibits autophagic flux, osteoclastogenesis and TGF-β1-induced M2 polarization, while reducing collagen deposition and effectively promoting the proliferation, differentiation and mineralization of osteoblasts. Orcinol glucoside also exhibits anti-pulmonary fibrosis, anxiolytic and antidepressant activities. Orcinol glucoside can be used in the research of senile and glucocorticoid-induced osteoporosis, idiopathic pulmonary fibrosis (IPF), anxiety and other related diseases .

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Ganoderic acid DM

1 Cited Publications

Cat. No.: HY-120140

CAS No.: 173075-45-1

Purity: 99.65%

Category:

Triterpenes Terpenoids Polyporaceae Metabolic Disease Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Inflammation/Immunology

Target:

Apoptosis PI3K

Ganoderic acid DM, a natural triterpenoid isolated from Ganoderma lucidum, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Ganoderic acid DM as a specific inhibitor of osteoclastogenesis .

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Rubiadin-1-methyl ether

1 Cited Publications

Cat. No.: HY-N1956

CAS No.: 7460-43-7

Category:

Quinones Monophenols Anthraquinones Rubiaceae Metabolic Disease Phenols Plants Disease Research Fields Rubia cordifolia L.

Target:

NF-κB RANKL/RANK Autophagy TGF-β Receptor

Rubiadin-1-methyl ether is an orally potent NF-κB p65 inhibitor and autophagy inhibitor. Rubiadin-1-methyl ether inhibits RANKL-induced phosphorylation and nuclear translocation of p65, suppresses BECN1 transcription, blocks LC3 conversion and autophagosome formation, thereby reducing the levels of BECN1 mRNA and Beclin1 protein. Rubiadin-1-methyl ether inhibits osteoclastogenesis, cell proliferation, macrophage M2 polarization and the TGF-β1 signaling pathway, and effectively alleviates pulmonary inflammation. Rubiadin-1-methyl ether is widely used in research on osteoporosis, pulmonary fibrosis, idiopathic pulmonary fibrosis, acute lung injury and other related diseases .

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