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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
peptide beta-sheet formation
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "peptide beta-sheet formation" in MCE Product Catalog:
Cat. No.: HY-P1889
CAS No.: 721885-31-0
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Bim BH3, Peptide IV is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV can be used for research on Alzheimer's disease .
Cat. No.: HY-P1047
CAS No.: 182912-74-9
Synonyms: [Pro18, Asp21] β-Amyloid (17-21)
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β-Sheet Breaker Peptide iAβ5 ([Pro18, Asp21] β-Amyloid (17-21)) is an amyloid fibril disaggregation inducer. β-Sheet Breaker Peptide iAβ5 inhibits fibril formation and disaggregates preformed fibrils by binding to the central hydrophobic region of Aβ (LVFFA) and disrupting the interactions between Aβ monomers/oligomers. β-Sheet Breaker Peptide iAβ5 reproducibly induces the disaggregation of fibrillar amyloid deposits in rat brain. β-Sheet Breaker Peptide iAβ5 prevents and reverses Aβ-induced neuronal shrinkage, reduces IL-1β-positive microglia surrounding Aβ deposits, and decreases the size of cerebral amyloid plaques. β-Sheet Breaker Peptide iAβ5 labeled with HBA enables blue quantitative detection under acidic conditions. β-Sheet Breaker Peptide iAβ5 is used in research related to Alzheimer's disease .
Cat. No.: HY-P5905
Synonyms: Citrullinated Aβ (1-42); Citrullinated Aβ42
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Cat. No.: HY-P2399
CAS No.: 957780-56-2
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Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH is a dipeptide building block containing a pseudoproline, which is used in studies related to Fmoc solid-phase peptide synthesis. Fmoc-Glu(OtBu)-Thr(psi(Me,Me)pro)-OH inhibits premature β-sheet aggregation during solid-phase peptide synthesis .
Cat. No.: HY-P4370
CAS No.: 342790-23-2
Cat. No.: HY-P5967
CAS No.: 189064-06-0
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Cat. No.: HY-P5515
CAS No.: 409085-40-1
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Cat. No.: HY-P5906
Synonyms: Citrullinated Aβ (1-40); Citrullinated Aβ40
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Cat. No.: HY-P1889A
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Bim BH3, Peptide IV TFA is an Aβ42-binding peptide and the pro-apoptotic BH3 domain of the BIM protein. Bim BH3, Peptide IV TFA binds Aβ42 with a Kd of 7.1 μM. Bim BH3, Peptide IV TFA modulates Aβ42 structure, fibrillization pathways, aggregate morphology, and membrane interactions, inhibiting fibril formation while enhancing protofibril assembly. Bim BH3, Peptide IV TFA promotes Aβ42 β-sheet formation and accelerates aggregation. Bim BH3, Peptide IV TFA enhances Aβ42 membrane internalization and bilayer stiffening. Bim BH3, Peptide IV TFA induces neuronal cell death by enhancing BH3-induced membrane interactions of Aβ42 prefibrillar species. Bim BH3, Peptide IV TFA can be used for research on Alzheimer's disease .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
