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pharmaceutical composition

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-145412
    GLP-1 receptor agonist 7

    		GLP Receptor Metabolic Disease
    GLP-1 receptor agonist 7 (Compound 130b) is a potent agonist of glucagon-like peptide-1 (GLP-1). GLP-1 receptor agonist 7 generates cAMP under the mediation of GLP-1R with an EC50 of ≤ 0.2 nM. GLP-1 receptor agonist 7 can be used to study diseases related to the GLP-1 receptor (particularly type 2 diabetes) .
    GLP-1 receptor agonist 7
  • HY-156529
    pan-KRAS-IN-2

    		Ras Cancer
    pan-KRAS-IN-2 (Compound 6) is a pan-inhibitor with IC50s ≤ 10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A and Q61H); and an IC50 > 10 μM for KRAS G13D. pan-KRAS-IN-2 can be used to study various KRAS-mediated cancers, such as pancreatic cancer and colorectal cancer .
    pan-KRAS-IN-2
  • HY-150402
    MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan

    		Drug-Linker Conjugates for ADC Topoisomerase Cancer
    MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan is a pharmaceutical composition containing antibody agent conjugate (ADC). (extracted from patent WO2021190581 Example 1-8) .
    MC-Gly-Gly-Phe-Gly-amide-cyclopropanol-amide-Exatecan
  • HY-W127489
    3-Pentadecylphenol

    		Biochemical Assay Reagents Others
    3-PentadecylphenolIt is an organic compound belonging to the phenolic class. It is attached to the phenolic ring by 15Carbon pentadecyl chain composition, with a touch of sweetness.3-Pentadecylphenol has various applications in the chemical and pharmaceutical industries, especially as an intermediate in the synthesis of various chemicals and pharmaceuticals. In addition, it can be used as an antioxidant for plastics and rubber.
    3-Pentadecylphenol
  • HY-156574
    DGKζ-IN-4

    		DGK Cancer
    DGKζ-IN-4 is a DGK-zeta inhibitor. DGKζ-IN-4 can be used as an active component of pharmaceutical compositions. DGKζ-IN-4 is used to treat cancers associated with immune cell activation or cancers resistant to anti-PD-1 antibody/anti-PD-11 antibody research .
    DGKζ-IN-4
  • HY-178769
    GLP-1R agonist 36

    		GLP Receptor Metabolic Disease
    GLP-1R agonist 36 (Compound 53) is a GLP-1R agonist with a total of four isomers. GLP-1R agonist 36 can be used for the studies of diabetes and obesity.
    GLP-1R agonist 36
  • HY-176946
    PTH1R agonist 4

    		PTHR Metabolic Disease
    PTH1R agonist 4 (Example 63) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC50 value greater than 7. PTH1R agonist 4 can be used for the study of bone diseases, such as osteoporosis .
    PTH1R agonist 4
  • HY-178768
    GLP-1R agonist 35

    		GLP Receptor Metabolic Disease
    GLP-1R agonist 35 (Compound 111-2) is a GLP-1R agonist with an EC50 of 0-10 nM. GLP-1R agonist 36 can be used for the studies of diabetes and obesity .
    GLP-1R agonist 35
  • HY-178283
    EGFR-IN-177

    		EGFR Cancer
    EGFR-IN-177 is a potent EGFR inhibitor with IC50s of 0.32, 1.04, 0.65, 0.67, 0.48, 0.55 and 0.38 nM against EGFR L858R, EGFR L858R/T790M, EGFR L858R/T790M/C797S, EGFR D746-750, EGFR D746-750/C797S, EGFR D770_N77linsNPG, and EGFR WT. EGFR-IN-177 inhibits lung cancer proliferation and EGFR phosphorylation. EGFR-IN-177 can be used for the study of cancers such as non-small cell lung cancer .
    EGFR-IN-177
  • HY-176945
    PTH1R agonist 3

    		PTHR Metabolic Disease
    PTH1R agonist 3 (Example 47) is a parathyroid hormone 1 receptor (PTH1R) agonist with a pEC50 value of less than 6. PTH1R agonist 3 can be used for the study of bone diseases, such as osteoporosis .
    PTH1R agonist 3
  • HY-139908
    MERS-CoV-IN-1

    		SARS-CoV Infection
    MERS-CoV-IN-1 exhibits excellent inhibitory activity against coronavirus. MERS-CoV-IN-1 is useful as a pharmaceutical composition for preventing coronavirus-induced diseases (MERS-CoV and SARS) (extracted from patent WO2018174442A1, compound 1) .
    MERS-CoV-IN-1
  • HY-160757
    NLRP3 modulator 7

    		NOD-like Receptor (NLR) Interleukin Related Inflammation/Immunology
    NLRP3 modulator 7 (Compound 17B) is a NLRP3 inflammasome regulator. NLRP3 modulator 7 has inhibitory activity against IL-1b, and its IC50 is less than 500 nM .
    NLRP3 modulator 7
  • HY-179590
    IL-17-IN-4

    		Interleukin Related Inflammation/Immunology
    IL-17-IN-4 (Compound 3) is an IL-17 inhibitor with an IC50 of less than 0.1 μM. IL-17-IN-4 can be used for the study of inflammatory diseases .
    IL-17-IN-4
  • HY-N16538
    4-(Acetoxymethyl)phenyl glucoside

    		Drug Derivative Cardiovascular Disease Neurological Disease
    4-(Acetoxymethyl)phenyl glucoside is a type of gastrodin derivative that can cross the blood-brain barrier. 4-(Acetoxymethyl)phenyl glucoside exhibits sedative, anticonvulsant and analgesic effects in mouse models. 4-(Acetoxymethyl)phenyl glucoside can be used for research on senile cardiovascular and cerebrovascular diseases as well as brain nerve disorders .
    4-(Acetoxymethyl)phenyl glucoside
  • HY-180428
    BRM/BRG1 ATP degrader-1

    		Epigenetic Reader Domain Cancer
    BRM/BRG1 ATP degrader-1 (Compound 1) is a BRG1/BRM degrader with IC50 values for the degradation of BRM IF and BRG1 IF of 0.01-0.1 μM and > 0.1 μM respectively. BRM/BRG1 ATP degrader-1 can be used for cancer research .
    BRM/BRG1 ATP degrader-1
  • HY-179688
    PROTAC CDK2/4 Degrader-1

    		PROTACs CDK Cancer
    PROTAC CDK2/4 Degrader-1 (Compound 5) is a CDK2/4 PROTAC degrader, with its DC50 values for CDK2 and CDK4 both ≤ 10 nM. PROTAC CDK2/4 Degrader-1 exhibits excellent inhibitory activity against cell proliferation in OVCAR3 and T47D cells. PROTAC CDK2/4 Degrader-1 can be used for research on breast cancer and ovarian cancer .
    PROTAC CDK2/4 Degrader-1
  • HY-180122
    (Rac)-Azide-deoxy-ascomycin-O-ethylene

    		Drug Derivative Inflammation/Immunology
    (Rac)-Azide-deoxy-ascomycin-O-ethylene, a nitrogen-containing compound, is a derivative of a macrolide-type immunosuppressant.
    (Rac)-Azide-deoxy-ascomycin-O-ethylene
  • HY-185006
    TRPV4 antagonist 5

    		TRP Channel Others
    TRPV4 antagonist 5 (Example 21) is a TRPV4 antagonist .
    TRPV4 antagonist 5
  • HY-179728
    Amylin agonist 1

    		Amylin Receptor CGRP Receptor Metabolic Disease
    Amylin agonist 1 (Example 239a) is a receptor 3 for pancreatic amyloid peptide (bAMY3R) agonist, and its EC50 for stimulating cAMP production in cells is 6.17 nM. Amylin agonist 1 is also a receptor for calcitonin (bCTR) agonist, with its EC50 being 8.58 nM. Amylin agonist 1 can be used for research on type 2 diabetes and obesity .
    Amylin agonist 1
  • HY-176948
    M-1111

    		mTOR Cancer
    M-1111 is a Rapa-Link inhibitor. M-1111 is covalently linked by Rapamycin (HY-10219) and an inhibitor of the active site mTOR. M-1111 has strong inhibitory activity on the mTORC1 signaling pathway (pS6 and p4E-BP1). M-1111 has nanomolar-level inhibitory activity against various cancer cells. M-1111 completely inhibits p4E-BP1 without inhibiting pAkt S473. M-1111 can be used for research on liver cancer, kidney cancer, and colorectal cancer .
    M-1111

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