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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
phosphoramidite building block
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "phosphoramidite building block" in MCE Product Catalog:
Research Areas:
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .
Cat. No.: HY-W008849
CAS No.: 102212-98-6
Cat. No.: HY-21648
CAS No.: 199593-09-4
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2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite that can be used for oligonucleotide synthesis .
Cat. No.: HY-164583
CAS No.: 2923115-67-5
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DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite allows site-specific introduction of a 2'-O-C22 lipophilic modification at adenosine positions to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. DMTr-2'-O-C22-rA-3'-CE-Phosphoramidite can be used for the construction and mechanism research of nucleic acid silencing molecules .
Cat. No.: HY-W141394
CAS No.: 85079-00-1
Synonyms: N-Benzoyl-2′-O-methyladenosine
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Bz-OMe-rA (N-Benzoyl-2′-O-methyladenosine) is a nucleoside analog with an N-benzoyl protecting group and a 2'-O-methyladenosine phosphoramidite unit. Bz-OMe-rA serves as a starting material for the chemical synthesis of the 5'-terminal cap structure of cytoplasmic polyhedrosis virus mRNA and also acts as a building block for solid-phase RNA oligonucleotide synthesis .
Cat. No.: HY-164582
CAS No.: 2923115-93-7
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DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite is an RNA phosphoramidite monomer. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite enables site-specific introduction of 2'-O-C22 lipophilic modification at cytidine positions during oligonucleotide synthesis, which is used to construct double-stranded RNA (dsRNA) molecules with extrahepatic delivery capability. DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite supports target gene silencing in skeletal muscle, cardiac muscle and adipose tissue by enhancing the lipophilicity and tissue uptake efficiency of dsRNA. Construction and mechanism study of DMTr-2'-O-C22-rC (Ac)-3'-CE-Phosphoramidite nucleic acid silencing molecules .
Cat. No.: HY-171631
CAS No.: 2133842-85-8
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5'-O-DMTr-Nap-dU-3'-CE Phosphoramidite is a phosphoramidite monomer used in nucleic acid synthesis, such as oligonucleotides.
Cat. No.: HY-177363
CAS No.: 2243974-81-2
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Morpholino G phosphoramidite (Compound 4b) is a nucleoside building block that is used for synthesis of morpholino oligonucleotides. Morpholino G phosphoramidite can be used for oligonucleotide therapies research .
Cat. No.: HY-17652
CAS No.: 1037305-43-3
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Morpholino T phosphoramidite is a nucleoside building block that has been used in the synthesis of morpholino oligonucleotides .
Cat. No.: HY-177385
CAS No.: 2304678-30-4
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Morpholino C phosphoramidite (Compound 4c) is a nucleoside building block that can be used for synthesis of morpholino oligonucleotides. Morpholino C phosphoramidite can be used for oligonucleotide therapies research .
Cat. No.: HY-17653
CAS No.: 2243974-80-1
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Morpholino A phosphoramidite is a specialized chemical building block used to synthesize Phosphorodiamidate Morpholino Oligomers (PMOs). Morpholino A phosphoramidite contains the adenine (A) nucleobase attached to a morpholine ring, fitted with a phosphoramidite group. PMOs are synthetic gene knockdown tools heavily used in developmental biology and targeted therapeutics to inhibit gene expression or alter RNA splicing .
Cat. No.: HY-65036
CAS No.: 36953-37-4
Synonyms: 4-Bromo-2-pyridone
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4-Bromo-2-hydroxypyridine (4-Bromo-2-pyridone) is a brominated pyridine/pyridone chemical building block. 4-Bromo-2-hydroxypyridine exists in tautomeric forms between 2-hydroxypyridine and pyridin-2 (1H)-one. 4-Bromo-2-hydroxypyridine is used for the synthesis of bromopyridone nucleoside analogs, phosphoramidite intermediates, and 4-phenylpyridin-2-one derivatives. 4-Bromo-2-hydroxypyridine is applied in studies on heterocyclic synthesis and oligonucleotide modification chemistry .
Cat. No.: HY-W369135
CAS No.: 133975-85-6
Synonyms: TFA-aminolinker C6 phosphoramidite
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TFA-Hexylaminolinker Phosphoramidite (TFA-aminolinker C6 phosphoramidite) is a phosphoramidite monomer used in oligonucleotide synthesis.
Cat. No.: HY-403188
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5'(E)-VP-2'-OMe-Bz-C Phosphoramidite is a phosphoramidite monomer used in nucleic acid synthesis, such as oligonucleotides.
Cat. No.: HY-W784611
CAS No.: 195375-65-6
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3'-NH-Tr-2',3'-ddC(Bz)-5'-CE-Phosphoramidite is a phosphoramidite monomer used in nucleic acid synthesis, such as oligonucleotides.
Cat. No.: HY-W881217
CAS No.: 182625-68-9
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DMT-iBu-G-(S)-GNA Phosphoramidite is a phosphoramidite monomer used in nucleic acid synthesis, such as oligonucleotides.
Cat. No.: HY-D1410
CAS No.: 2758388-05-3
Synonyms: DMTr-4'-F-5-Methyluridine-CED phosphoramidite
Cat. No.: HY-W800446
CAS No.: 709641-79-2
Synonyms: Lna-g amidite
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LNA-Guanosine 3'-CE phosphoramidite (Lna-g amidite) is an essential building block to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which includes a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, paralleling DNA polymer assembly.
Cat. No.: HY-188039
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2'-OMe-VPTm Phosphoramidite is a 2'-O-methylthymidine phosphoramidite monomer that can be used as a building block in oligonucleotide synthesis to introduce 2'-O-methyl-modified thymidine residues. 2'-OMe-VPTm Phosphoramidite can be used in RNA modification and nucleic acid chemistry research.
Cat. No.: HY-188038
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2'-OMe-VPGm (N-dmf) Phosphoramidite is a 2'-O-methylguanosine phosphoramidite monomer that can be used as a building block in oligonucleotide synthesis to introduce 2'-O-methyl-modified guanosine residues. 2'-OMe-VPGm (N-dmf) Phosphoramidite can be used in RNA modification and nucleic acid chemistry research.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
