155 Results for "

protective. Anti-inflammatory

" in MedChemExpress (MCE) Product Catalog:
Products (155)

155 Results for "protective. Anti-inflammatory" in MCE Product Catalog:

53
Berberine hemisulfate
Berberine hemisulfate
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53 Publications Verification
Cat. No.: HY-N0716A
CAS No.: 316-41-6
Synonyms: Natural Yellow 18 hemisulfate
Category:  

Infection Alkaloids Ranunculaceae Coptis chinensis Franch. Metabolic Disease Plants Disease Research Fields Isoquinoline Alkaloids Cancer

Target:  

Antibiotic Topoisomerase Autophagy Bacterial Reactive Oxygen Species (ROS) Apoptosis PI3K Akt Caspase JNK AP-1 NF-κB

Berberine hemisulfate is the hemisulfate form of Berberine (HY-N0716). Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. Berberine hemisulfate exhibits anti-inflammatory, antibiobic, antitumor, cardiovascular protective and neuroprotective activity .
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28
Oxytocin
Oxytocin
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28 Cited Publications
Cat. No.: HY-17571
CAS No.: 50-56-6
Synonyms: α-Hypophamine; Oxytocic hormone
Category:  

Natural Products Monophenols Animals Phenols Endogenous metabolite Disease Research Fields Endocrinology

Target:  

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine; Oxytocic hormone) is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
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28
Oxytocin acetate
Oxytocin acetate
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28 Cited Publications
Cat. No.: HY-17571A
CAS No.: 6233-83-6
Synonyms: α-Hypophamine acetate; Oxytocic hormone acetate
Category:  

Natural Products Endogenous metabolite Disease Research Fields Endocrinology Cancer

Target:  

Oxytocin Receptor Endogenous Metabolite

Oxytocin (α-Hypophamine) acetate is a pleiotropic, hypothalamic peptide known for facilitating parturition, lactation, and prosocial behaviors. Oxytocin acetate can function as a stress-coping molecule with anti-inflammatory, antioxidant, and protective effects especially in the face of adversity or trauma .
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13
Glabridin
Glabridin
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13 Cited Publications
Cat. No.: HY-N0393
CAS No.: 59870-68-7
Category:  

Plants Infection Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Isoflavones

Target:  

PPAR Reactive Oxygen Species (ROS) Bacterial

Glabridin is a natural isoflavan from Glycyrrhiza glabra L., binds to and activates PPARγ, with an EC50 of 6115 nM. Glabridin exhibits antioxidant, anti-bacterial, anti-nephritic, anti-diabetic, anti-fungal, antitumor, anti-inflammatory, antiosteoporotic, cardiovascular protective, neuroprotective and radical scavenging activities .
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11
Ligustrazine
Ligustrazine
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11 Cited Publications
Cat. No.: HY-N0264
CAS No.: 1124-11-4
Synonyms: Chuanxiongzine; Tetramethylpyrazine
Category:  

Cardiovascular Disease Natural Products Neurological Disease Metabolic Disease Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine (Chuanxiongzine) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
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11
Ligustrazine hydrochloride
Ligustrazine hydrochloride
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11 Cited Publications
Cat. No.: HY-N0935
CAS No.: 76494-51-4
Synonyms: Chuanxiongzine hydrochloride; Tetramethylpyrazine hydrochloride
Category:  

Alkaloids Other Alkaloids Other Diseases Dicerothamnus rhinocerotis Plants Umbelliferae Disease Research Fields

Target:  

Reactive Oxygen Species (ROS) Akt NO Synthase Aminotransferases (Transaminases)

Ligustrazine hydrochloride (Chuanxiongzine hydrochloride) is an orally active, blood-brain barrier-permeable alkaloid. It can be isolated from Ligusticum striatum DC. Ligustrazine hydrochloride reduces ROS, upregulates the levels of p-Akt/Akt and p-eNOS/eNOS, and decreases ALT and AST. It inhibits glutamate excitotoxicity, calcium overload, oxidative stress, ischemia-reperfusion injury and atherosclerotic plaque progression, enhances synaptic plasticity, and improves neurological function, cerebral infarct volume and brain water content. Ligustrazine hydrochloride possesses anti-inflammatory, antioxidant, lipid-lowering, endothelial protective and hepatoprotective activities. It can be used in studies related to ischemic stroke, cerebral ischemia-reperfusion injury and atherosclerosis .
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9
Cycloastragenol
Cycloastragenol
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9 Cited Publications
Cat. No.: HY-N1485
CAS No.: 78574-94-4
Synonyms: Astramembrangenin; Cyclosieversigenin
Category:  

Triterpenes other families Terpenoids Plants

Target:  

Telomerase

Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties .
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7
Loganin
Loganin
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7 Cited Publications
Cat. No.: HY-N0512
CAS No.: 18524-94-2
Synonyms: Loganoside
Category:  

Cornaceae Iridoids Cornus officinalis Sieb. et Zucc. Terpenoids Plants Disease Research Fields Cancer

Target:  

Reactive Oxygen Species (ROS) TNF Receptor Interleukin Related

Loganin is a type of iridoid glycoside compound that possesses anti-inflammatory, antioxidant, and antitumor properties, and offers protective effects against acute lung injury and pulmonary fibrosis. Loganin exerts its protective effects against LPS (HY-D1056)-mediated inflammation and oxidative stress by upregulating the Nrf2/HO-1 signaling pathway, and it reduces neuroinflammation caused by spinal cord injury (SCI) .
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5
Linalool,98% (stabilized with MEHQ)
Linalool,98% (stabilized with MEHQ)
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5 Cited Publications
Cat. No.: HY-N0368
CAS No.: 78-70-6
Category:  

Cardiovascular Disease Other Monoterpenes Terpenoids Amberboa moschata (L.) DC. Plants Umbelliferae Endogenous metabolite Disease Research Fields

Target:  

Environmental Pollutants Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor

Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .
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5
Asiatic acid
Asiatic acid
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5 Cited Publications
Cat. No.: HY-N0194
CAS No.: 464-92-6
Category:  

Triterpenes Terpenoids Centella asiatica (L.) Urb. Plants Umbelliferae Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis Parasite

Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .
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5
HSA Protein
HSA Protein
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5 Cited Publications
Cat. No.: HY-P1956
CAS No.: 70024-90-7
Synonyms: Human serum albumin
HSA Protein (Human serum albumin) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. HSA Protein exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. HSA Protein can block the inhibitory effect of GML on human T cells, providing protective function for T cells. HSA Protein is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ?) in the vascular wall, contributing to the reduction of blood pressure .
This product is recombinant HSA Protein expressed in a microbial expression system.
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4
Harpagoside
Harpagoside
0 Images
4 Cited Publications
Cat. No.: HY-N0396
CAS No.: 19210-12-9
Category:  

Iridoids Terpenoids Pedaliaceae Plants Disease Research Fields Inflammation/Immunology Harpagophytum procumbens

Target:  

COX NO Synthase

Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ).
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4
(±)-Naringenin
(±)-Naringenin
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4 Cited Publications
Cat. No.: HY-W011641
CAS No.: 67604-48-2
Category:  

Cardiovascular Disease other families Flavonoids Flavonones Phenols Polyphenols Plants Disease Research Fields

Target:  

Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase

(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BKCa channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .
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4
Tricarbonyldichlororuthenium(II) dimer
Tricarbonyldichlororuthenium(II) dimer
0 Images
4 Cited Publications
Cat. No.: HY-W033577
CAS No.: 22594-69-0
Synonyms: CORM-2
Target:  

P2X Receptor Potassium Channel NO Synthase STAT Interleukin Related

Research Areas:  

Inflammation/Immunology

Tricarbonyldichlororuthenium(II) dimer (CORM-2) is a CO-releasing molecule. Tricarbonyldichlororuthenium(II) dimer exhibits anti-inflammatory, antioxidant, and gastric mucosa-protective activities. Additionally, Tricarbonyldichlororuthenium(II) dimer has CO-independent functional effects on multiple potassium channels .
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3
Sanggenon C
Sanggenon C
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3 Cited Publications
Cat. No.: HY-N0617
CAS No.: 80651-76-9
Category:  

Cardiovascular Disease Plants Moraceae Flavanonols Flavonoids Phenols Polyphenols Disease Research Fields Inflammation/Immunology Morus alba Linn.

Target:  

Phosphatase ERK NF-κB Apoptosis

Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .
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3
6-Hydroxyflavone
6-Hydroxyflavone
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3 Cited Publications
Cat. No.: HY-N7110
CAS No.: 6665-83-4
Category:  

Flavonoids Monophenols Flavones Labiatae Phenols Plants Disease Research Fields Medicago truncatula Gaertn. Inflammation/Immunology

Target:  

Akt ERK JNK GABA Receptor

6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABAA) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role .
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2
Schisandrol B
Schisandrol B
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2 Cited Publications
Cat. No.: HY-N0692
CAS No.: 58546-54-6
Synonyms: Gomisin-A; TJN-101; Wuweizi alcohol-B
Category:  

Lignans Phenylpropanoids Plants Schisandraceae Disease Research Fields Schisandra chinensis (Turcz.) Baill. Cancer

Target:  

Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy

Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .
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2
Tilianin
Tilianin
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2 Cited Publications
Cat. No.: HY-N2555
CAS No.: 4291-60-5
Category:  

Cardiovascular Disease Flavones Plants Crotalaria candicans Wight & Arn. Flavonoids Monophenols Labiatae Phenols Disease Research Fields Inflammation/Immunology

Target:  

Others

Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects .
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2
Xanthotoxol
Xanthotoxol
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2 Cited Publications
Cat. No.: HY-30152
CAS No.: 2009-24-7
Synonyms: 8-Hydroxypsoralen
Category:  

other families Monophenols Coumarins Phenols Phenylpropanoids Plants Endogenous metabolite

Target:  

5-HT Receptor Reactive Oxygen Species (ROS) Endogenous Metabolite

Xanthotoxol (8-Hydroxypsoralen) It is a kind of fragrant bean substance, and it is a CYP450 inhibitor. Xanthotoxol has anti-inflammatory, anti-inflammatory, and 5-HT antagonistic and protective effects. Xanthotoxol inhibited CYP3A4 sum CYP1A2 IC50s separation 7.43 μM sum 27.82 μM. Xanthotoxol can pass through MAPK and NF-κB, inhibiting inflammation.
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2
Sinapine
Sinapine
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2 Cited Publications
Cat. No.: HY-N5077
CAS No.: 18696-26-9
Category:  

Alkaloids Monophenols Neurological Disease Other Alkaloids Cruciferae Phenols Plants Disease Research Fields Inflammation/Immunology

Target:  

Cholinesterase (ChE) P-glycoprotein

Sinapine is an alkaloid isolated from seeds of the cruciferous species. Sinapine exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease .
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