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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
protein farnesyltransferase
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "protein farnesyltransferase" in MCE Product Catalog:
Target:
Research Areas:
FTI 276 TFA is a farnesyltransferase (FTase) inhibitor with an IC50 of 0.5 nM, and it exhibits selectivity for FTase over geranylgeranyltransferase I (GGTase I). FTI 276 TFA blocks the farnesylation of H-Ras and K-Ras4B, causes inactive Ras-Raf complexes to accumulate in the cytoplasm, and inhibits constitutive MAPK activation. FTI 276 TFA reduces the number, incidence and volume of tumors, and restricts the growth of tumors expressing activated K-ras. FTI 276 TFA can be used in research related to pulmonary adenoma .
Cat. No.: HY-118563
CAS No.: 135784-48-4
Cat. No.: HY-16111A
CAS No.: 195981-08-9
Target:
Research Areas:
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase (Farnesyl Transferase). BMS-214662 hydrochloride can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. The IC50 value of BMS-214662 hydrochloride for H-Ras is 1.3 nM, and for K-Ras it is 8.4 nM. BMS-214662 hydrochloride can be used in the research of tumor diseases related to Ras .
Cat. No.: HY-15872
CAS No.: 170006-73-2
Research Areas:
FTI-277 is a farnesyltransferase (FTase) inhibitor. FTI-277 inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .
Cat. No.: HY-110038
CAS No.: 1217447-06-7
Research Areas:
FTI-277 TFA is a farnesyltransferase (FTase) inhibitor. FTI-277 TFA inhibits Ras farnesylation, blocks the phosphorylation of downstream ERK1/2 and mTOR, and reduces membrane-bound active N-ras protein. FTI-277 TFA activates caspase 3, upregulates Bim expression, induces cell apoptosis, suppresses regulatory T cell expansion, enhances macrophage phagocytosis, and improves bacterial clearance. FTI-277 TFA activates the PI3K/Akt signaling pathway, inhibits osteoblast differentiation, and reduces the proliferation ability of neuroblastoma cells. FTI-277 TFA can be used in research related to head and neck squamous cell carcinoma, neuroblastoma, sepsis, and vascular calcification .
Cat. No.: HY-116254
CAS No.: 160141-08-2
Target:
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L-739750 is a selective protein farnesyltransferase (PFTase) inhibitor (IC50: 0.4 nM). PFTase utilizes farnesyl diphosphate to farnesylate the cysteine residue of protein substrates having a C-terminal CAAX motif. L-739750 is a selective CAAX peptidomimetic .
Cat. No.: HY-151566
CAS No.: 2842067-19-8
Target:
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Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase .
Cat. No.: HY-U00327
CAS No.: 360561-53-1
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Research Areas:
Prenyl-IN-1 is a protein prenylation inhibitor, especially a geranylgeranyltransferase (GGT) or a farnesyltransferase (FT) inhibitor, exhibiting potent activity against oxidative stress, and particularly in the treatment of Parkinson's Disease.
Cat. No.: HY-117893
CAS No.: 201487-53-8
Target:
Research Areas:
BIM-46068 is a potent, selectively human brain Farnesyltransferase (FTase) inhibitor (IC50 = 91.4 nM). BIM-46068 can specifically inhibit Ras processing in MiaPaCa-2 cancer cells. BIM-46068 can be used for the study of pancreatic cancer .
Cat. No.: HY-N13874
CAS No.: 174232-43-0
Category:
Target:
Cat. No.: HY-N13876
CAS No.: 184432-08-4
Category:
Target:
Cat. No.: HY-N9604
CAS No.: 174232-44-1
Target:
Research Areas:
Andrastin B is a protein farnesyltransferase inhibitor. Andrastin B has a common androstane skeleton .
Cat. No.: HY-122469
CAS No.: 193696-42-3
Target:
Research Areas:
Kurasoin B is a protein farnesyltransferase inhibitor (IC50: 58.7 μM). Kurasoin B can be produced by Paecilomyces sp. FO-3684 .
Cat. No.: HY-P701885
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FNTA; Type I protein Geranyl-Geranyltransferase Subunit Alpha; farnesyltransferase, CAAX Box, Subunit Alpha; CAAX farnesyltransferase Subunit Alpha; protein farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha; farnesyltransferase, CAAX Box,
Species:
Human
Source:
E. coli
Cat. No.: HY-P701886
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FNTA; Type I protein Geranyl-Geranyltransferase Subunit Alpha; farnesyltransferase, CAAX Box, Subunit Alpha; CAAX farnesyltransferase Subunit Alpha; protein farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha; farnesyltransferase, CAAX Box,
Species:
Human
Source:
E. coli
Cat. No.: HY-P72193
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: FDFT1; Farnesyl-Diphosphate farnesyltransferase; Farnesyl-Diphosphate farnesyltransferase 1; Presqualene-Di-Diphosphate Synthase; SQS; Squalene Synthetase; Squalene Synthase; DGPT; FPP:FPP farnesyltransferase; ERG9; SS; SQSD
Species:
Human
Source:
E. coli
Cat. No.: HY-P83099A
Synonyms: FNTB; protein farnesyltransferase subunit beta; FTase-beta; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
Cat. No.: HY-183421
CAS No.: 146016-64-0
Synonyms: Gliotoxin monoacetate
Research Areas:
Acetylgliotoxin (Gliotoxin monoacetate) is a farnesyltransferase (FTase) inhibitor with an IC50 of 4.4 μM against human targets. Acetylgliotoxin inhibits the growth of fungal, bacterial, and viral pathogens; it binds to free protein thiols and induces ROS production. Acetylgliotoxin increases the survival rate of Caenorhabditis elegans infected with Candida albicans, but exhibits toxicity at higher concentrations. Acetylgliotoxin is applicable to research related to Candida albicans infections .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
