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proteinase 3 (PR3)

" in MedChemExpress (MCE) Product Catalog:

標的別:	Cathepsin (1) Elastase (1)
研究分野別:	Cancer (1) Inflammation/Immunology (1)

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Targets Recommended: Procollagen C Proteinase

製品番号	製品名	Target	研究分野	構造式

HY-155414

Neutrophil elastase inhibitor 5	Elastase	Inflammation/Immunology
Neutrophil elastase inhibitor 5 (compound 29) is a dual inhibitor of HNE (human neutrophil elastase) and proteinase 3 (PR3) with IC₅₀ values of 4.91 μM and 20.69 μM, respectively. Neutrophil elastase inhibitor 5 can be used in the study of neutrophil inflammatory diseases .

HY-P2922

Cathepsin C	Cathepsin	Cancer
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .

製品番号	製品名	Target	研究分野

HY-P10461

Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp	ペプチド	Others
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human *proteinase 3* (k_cat/K_m = 1,570 mM ^-1s ^-1), and can be used for detection of proteinase 3 (PR3) activity .

Species:	Human (3)
Tag:	His (3)
Source:	HEK293 (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P70509

	PRTN3 Protein, Human (HEK293, His, solution) 1 Publications Verification Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration. PRTN3 Protein, Human (HEK293, His, solution) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70509A

	PRTN3 Protein, Human (HEK293, C-His) Myeloblastin; AGP7; C-ANCA Antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener Autoantigen; PRTN3; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation.It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration.PRTN3 Protein, Human (HEK293, C-His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P76552

	PRTN3 Protein, Human (S203A, HEK293, His) Myeloblastin; AGP7; Leukocyte proteinase 3; PR-3; P29; Wegener autoantigen; MBN	Human	HEK293
	PRTN3 is a serine protease that broadly targets elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in vitro, playing a crucial role in extracellular matrix degradation. It modulates endothelial cell barrier function by cleaving and activating the receptor F2RL1/PAR-2 and enhances vascular integrity during neutrophil transendothelial migration. PRTN3 Protein, Human (S203A, HEK293, His) is the recombinant human-derived PRTN3 protein, expressed by HEK293 , with C-His labeled tag and S203A mutation.

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Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3) Mouse (2)
Application:	IHC-P (1) ICC/IF (2) IF-Tissue (1) IHC-F (1) FC (2) ELISA (2)
Isotype:	IgG (1) IgG2b (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P85332

	PR3 Antibody (YA5024) PRTN3; MBN; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen	ICC/IF, FC, ELISA	Human, Mouse
	PR3 Antibody (YA5024) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PR3.

HY-P85332A

	PR3 Antibody (YA5024)(PBS only) PRTN3; MBN; Myeloblastin; AGP7; C-ANCA antigen; Leukocyte proteinase 3; PR-3; PR3; Neutrophil proteinase 4; NP-4; P29; Wegener autoantigen	ICC/IF, FC, ELISA	Human, Mouse
	PR3 Antibody (YA5024) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PR3.

HY-P86686

	PR3 Antibody (YA6378) ACPA; AGP 7; AGP7; AGP7 serine proteinase; Azurophil Granule Protein 7; C ANCA antigen; C-ANCA antigen; EC 3.4.21.76; Leukocyte proteinase 3; MBN; MBT WEGENER AUTOANTIGEN; Myeloblastin; Neutrophil proteinase 4; NP 4; NP-4; NP4; P29; PR 3; PR-3; proteinase3; PRTN 3; Prtn3; PRTN3_HUMAN; Serine proteinase neutrophil Wegener granulomatosis autoantigen; Wegener autoantigen.	IHC-P, IHC-F, IF-Tissue	Human
	PR3 Antibody (YA6378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PR3.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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