1042405-14-0
Chemical Structure
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp
- CAS No.: 1042405-14-0
- Formula:C53H80N20O18
- Molecular Weight:1285.33
InChIKey: GPQJSEVHWOLFEV-FIXJGUAHSA-N
SMILES: O=C([C@H](CCC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC(C1=CC=CC=C1N)=O)=O)=O)=O)CCC)=O)=O)=O)=O)NCCNC2=CC=C(C=C2[N+]([O-])=O)[N+]([O-])=O
Biological Activity: Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescent FRET substrate for proteinase 3 (PR3) with selectivity over neutrophil elastase and cathepsin G. Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is cleaved by active PR3 to generate a detectable fluorescent signal, which is used to quantify the enzymatic activity of PR3, the concentration of free or membrane-bound PR3, and the PR3 activity on activated human neutrophils. Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp can be applied in studies related to lung ischemia-reperfusion injury, inflammatory diseases, and other relevant conditions[1][2].
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Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp | 99.49% | Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescent FRET substrate for proteinase 3 (PR3) with selectivity over neutrophil elastase and cathepsin G. Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is cleaved by active PR3 to generate a detectable fluorescent signal, which is used to quantify the enzymatic activity of PR3, the concentration of free or membrane-bound PR3, and the PR3 activity on activated human neutrophils. Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp can be applied in studies related to lung ischemia-reperfusion injury, inflammatory diseases, and other relevant conditions. | ||||||||||||||||||||
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References
- [1]. Yu J, et al. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury. Redox biology. 2024 Aug;74:103231. [Content Brief]
- [2]. Korkmaz B, et al. Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates. Methods in molecular biology (Clifton, N.J.). 2012;844:125-38. [Content Brief]
