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Results for "

pyridine-based

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136561
    GRK5-IN-2
    4 Publications Verification

    		 G Protein-coupled Receptor Kinase (GRK) ERK Metabolic Disease
    GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research .
    GRK5-IN-2
  • HY-50071
    6-Amino-5-nitropyridin-2-one

    		Nucleoside Antimetabolite/Analog Others
    6-Amino-5-nitropyridin-2-one is a pyridine base and used as a nucleobase of hachimoji DNA, in which it pairs with 5-aza-7-deazaguanine .
    6-Amino-5-nitropyridin-2-one
  • HY-161950
    Tyrosinase-IN-33

    		Tyrosinase Metabolic Disease
    Tyrosinase-IN-33 (compound 5) a Pyridine-based compound, is a potent inhibitor of mushroom tyrosinase diphenolase activity. Tyrosinase-IN-33 significantly decreases the enzyme activity, with an IC50 of 9.0 μM .
    Tyrosinase-IN-33
  • HY-182366
    EED-IN-5

    		Histone Methyltransferase Neurological Disease Inflammation/Immunology
    EED-IN-5 is an orally active, EZH2-selective trisubstituted pyridine-based EED-H3K27me3 inhibitor and immunomodulator with anti-inflammatory activity. The IC50 value of EED-IN-5 against EED is 28.21 nM. In mouse models, EED-IN-5 preferentially and persistently accumulates in lymph nodes after oral administration. By reducing the H3K27me3 level of dendritic cells and inhibiting their migration, EED-IN-5 decreases the infiltration of specific dendritic cells, macrophages and T cells into the spinal cord and brain. EED-IN-5 exhibits hERG inhibitory activity, shows negative results in the Mini-Ames test, and causes no obvious toxicity upon long-term high-dose administration. EED-IN-5 can be used for the research of multiple sclerosis .
    EED-IN-5

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