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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
rat alveolar macrophages
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "rat alveolar macrophages" in MCE Product Catalog:
1
Category:
Target:
1
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Olprinone (Loprinone) is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
1
1 Cited Publications
Synonyms: Loprinone Hydrochloride
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Olprinone (Loprinone) Hydrochloride is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone Hydrochloride exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone Hydrochloride can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
Synonyms: Cloricromene hydrochloride; AD6 hydrochloride
Target:
Research Areas:
Cloricromen (Cloricromene) hydrochloride is an orally active platelet inhibitor. Cloricromen hydrochloride inhibits thromboxane B2 release, β-thromboglobulin, and thrombus formation. Cloricromen hydrochloride inhibits LPS (HY-D1056)-induced NF-κB activation, oxidative activity, and TNF-α expression. Cloricromen hydrochloride exhibits protective activity in animal models of shock and peripheral ischaemia. Cloricromen hydrochloride can be used for the research of myocardial ischaemia/reperfusion injury, and ischaemic cerebrovascular disease .
Cat. No.: HY-118160
CAS No.: 65240-86-0
Synonyms: NSC 73233
Target:
NO Synthase Drug Derivative IKK NF-κB HDAC Reactive Oxygen Species (ROS) AMPK mTOR PI3K Akt Autophagy Apoptosis
Research Areas:
Cardiovascular Disease Infection Neurological Disease Inflammation/Immunology Cancer
PPM-18 (NSC 73233) is a Vitamin K (HY-B2172) analog. PPM-18 prevents LPS-induced IκBα degradation, thereby inhibiting NF-κB activation and nuclear translocation of NF-κB. PPM-18 inhibits LPS-induced nitrite production and iNOS expression. PPM-18 inhibits HDAC6. PPM-18 induces ROS accumulation, activates AMPK, inhibits the mTORC1 and PI3K/AKT pathways, initiates Autophagy, and induces Apoptosis. PPM-18 suppresses seizures in zebrafish and mouse epilepsy models. PPM-18 prevents LPS-induced lethal toxicity and delayed hypotension. PPM-18 exhibits anticancer activity against leukemia and bladder cancer. PPM-18 can be used in research related to septic shock, bladder cancer and atherosclerosis .
Cat. No.: HY-14254AR
CAS No.: 106730-54-5
Synonyms: Loprinone (Standard)
Olprinone (Loprinone) Standard is the analytical standard of Olprinone (HY-14254A). This product is intended for research and analytical applications. Olprinone (Loprinone) is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
Cat. No.: HY-116678
CAS No.: 68206-94-0
Synonyms: Cloricromene; AD6
Target:
Research Areas:
Cloricromen (Cloricromene) is an orally active platelet inhibitor. Cloricromen inhibits thromboxane B2 release, β-thromboglobulin, and thrombus formation. Cloricromen inhibits LPS (HY-D1056)-induced NF-κB activation, oxidative activity, and TNF-α expression. Cloricromen exhibits protective activity in animal models of shock and peripheral ischaemia. Cloricromen can be used for the research of myocardial ischaemia/reperfusion injury, and ischaemic cerebrovascular disease .
Cat. No.: HY-N6777S
Cat. No.: HY-N19847
CAS No.: 1820750-36-4
Category:
Cat. No.: HY-14254B
CAS No.: 2072803-95-1
Synonyms: Loprinone hydrochloride hydrate
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Olprinone (Loprinone) hydrochloride hydrate is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone hydrochloride hydrate exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone hydrochloride hydrate can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
Cat. No.: HY-14254R
CAS No.: 119615-63-3
Synonyms: Loprinone Hydrochloride (Standard)
Olprinone (Loprinone) Hydrochloride Standard is the analytical standard of Olprinone (Hydrochloride) (HY-14254). This product is intended for research and analytical applications. Olprinone (Loprinone) Hydrochloride is a potent and selective phosphodiesterase 3 (PDE3) inhibitor, with IC50 values of 150, 100, 0.35, and 14 μM against PDE1, PDE2, PDE3, and PDE4, respectively. Olprinone Hydrochloride exerts comprehensive protective effects including anti-inflammatory, antioxidant, and anti-apoptotic activities by elevating intracellular cAMP levels and inhibiting the NF-κB and MAPK signaling pathways. Olprinone Hydrochloride can be used in studies related to lung injury, spinal cord injury, heart failure, myocardial ischemia-reperfusion injury, and cerebral ischemic injury .
Cat. No.: HY-FL14254B
CAS No.: 2072803-95-1
Synonyms: Loprinone hydrochloride hydrate solution
Research Areas:
Olprinone hydrochloride solution is mainly composed of Olprinone hydrochloride hydrate (HY-14254B). Olprinone hydrochloride hydrate is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone hydrochloride hydrate has anti-inflammatory activity, and is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity
Cat. No.: HY-128861B
CAS No.: 1403357-80-1
Synonyms: Dimethylaminomicheliolide hydrochloride; DMAMCL hydrochloride
Research Areas:
ACT001 (Dimethylaminomicheliolide; DMAMCL) hydrochloride is an orally active, blood-brain barrier-permeable anti-inflammatory and anti-tumor agent. ACT001 hydrochloride exerts microglia-mediated neuroanti-inflammatory effects by inhibiting the AKT/NF-κB/NLRP3 axis and suppressing apoptosis (apoptosis). ACT001 hydrochloride inhibits tumor proliferation by upregulating NKTR and inhibiting AKT. ACT001 hydrochloride alleviates metabolic-associated fatty liver disease by regulating gut microbiota and inhibiting ileal FXR. ACT001 hydrochloride inhibits pyroptosis (pyroptosis) and pro-inflammatory cytokine release by activating PPAR-γ and inhibiting NF-κB/NLRP3 .
Cat. No.: HY-187364
CAS No.: 3050594-88-9
Target:
Research Areas:
TRPV4 antagonist-7 is a potent and selective TRPV4 antagonist with an IC50 of 0.2 nM against human targets. TRPV4 antagonist-7 binds to the voltage-sensor-like domain cavity of TRPV4 and inhibits channel activity through the formation of salt bridges, hydrogen bonds, and edge-to-face π-stacking interactions. TRPV4 antagonist-7 induces phospholipid accumulation in HepG2 C3A cells in vitro with an IC50 of 3.8 μM, and exhibits moderate inhibitory effects on CYP2D6 with an IC50 of 5.1 μM. TRPV4 antagonist-7 dose-dependently inhibits GSK1016790A (HY-19608)-induced bronchoconstriction in rats and cough in guinea pigs. TRPV4 antagonist-7 can be used in studies related to respiratory system diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
