Olprinone hydrochloride solution
Olprinone hydrochloride solution is mainly composed of Olprinone hydrochloride hydrate (HY-14254B). Olprinone hydrochloride hydrate is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone hydrochloride hydrate has anti-inflammatory activity, and is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity
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- CAS No.: 2072803-95-1
- Formule: C14H13ClN4O2
- Masse moléculaire:304.73
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 2072803-95-1
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Masse moléculaire 304.73
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Formule C14H13ClN4O2
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SMILES
CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3.Cl.O
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Synonyms
Loprinone hydrochloride hydrate solution
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Koike T, Nadeen Qutab M, Tsuchida M, Takekubo M, Saito M, Hayashi J. Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect. Pulm Pharmacol Ther. 2008;21(1):166-71. [Content Brief]
[2]. Genovese T, Mazzon E, Paterniti I, Esposito E, Cuzzocrea S. Neuroprotective effects of olprinone after cerebral ischemia/reperfusion injury in rats. Neurosci Lett. 2011 Oct 3;503(2):93-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Olprinone hydrochloride solution Related Classifications
HY-FL14254B Related Classifications
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Keywords
- Olprinone hydrochloride solution
- 2072803-95-1
- Loprinone hydrochloride hydrate solution
- Apoptosis
- p38 MAPK
- NF-κB
- Phosphodiesterase (PDE)
- male Wistar rats
- macrophage activation
- myocardial ischemia-reperfusion injury
- intracellular cAMP
- spinal cord injury
- pro-inflammatory cytokines
- phosphodiesterase III
- rat alveolar macrophages
- neutrophil influx
- Inhibitor
- inhibitor
- inhibit