1820750-36-4
Chemical Structure
LYRM03
- CAS No.: 1820750-36-4
- Formula:C21H33N3O5
- Molecular Weight:407.50
InChIKey: PBLYJNWLOXWSSP-ITWBUVANSA-N
SMILES: CC[C@H](C)[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O)=O
Biological Activity: LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer[1][2][3][4][5].
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LYRM03 | LYRM03 is a derivative of Ubenimex (HY-B0134) and a Aminopeptidase N inhibitor. LYRM03 is isolated from Streptomyces HCCB10043. LYRM03 inhibits TLR4, MyD88, NLRP3, ASC, NF-κB and p38 MAPK, stabilizes IκB, and suppresses LPS-induced expression of iNOS and COX-2. LYRM03 reduces the levels of inflammatory cytokines and oxidative stress markers, and alleviates pulmonary edema. LYRM03 exhibits anticancer activity against breast cancer. LYRM03 has anti-inflammatory activity. LYRM03 can be used in the research of acute lung injury and breast cancer. | |||||||||||||||||||||
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References
- [1]. Wang B, et al. The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals. J Invest Surg. 2021;34(3):284-296. [Content Brief]
- [2]. He HQ, et al. LYRM03, an ubenimex derivative, attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. Acta Pharmacol Sin. 2017;38(3):342-350. [Content Brief]
- [3]. Jiang Q, et al. Posttreatment With LYRM03 Protects Rats From Acute Lung Inflammation Induced by Lipopolysaccharide via Suppressing the NF-κB/MyD88/TLR4 Axis. J Surg Res. 2019;243:316-324. [Content Brief]
- [4]. Yang YK, et al. Chemically synthesized LYRM03 could inhibit the metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. Bioorg Med Chem Lett. 2019 Jul 15;29(14):1719-1726. [Content Brief]
- [5]. He X. Diastereoselectivity control in MAC methodology for the preparation of α-hydroxy-β-amino acid derivatives[D]. Université Paris-Saclay, 2022.
