Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
ribonuclease H
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "ribonuclease H" in MCE Product Catalog:
7
Category:
Infection Quinones Leguminosae Anthraquinones Plants Disease Research Fields Senna alexandrina Milll
Target:
1
1 Cited Publications
Cat. No.: HY-W105970
CAS No.: 7758-16-9
Synonyms: Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
Cat. No.: HY-153491
CAS No.: 2097587-83-0
Synonyms: ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) is a GalNAc-modified antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
Synonyms: ISIS 678354 sodium; IONIS-APOCIII-LRx sodium; AKCEA-APOCIII-LRx sodium
Target:
Research Areas:
Olezarsen (ISIS 678354;IONIS-APOCIII-LRx) sodium is a GalNAc-modified antisense oligonucleotide. Olezarsen sodium binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen sodium reduces plasma triglyceride, apolipoprotein B and non-high-density lipoprotein cholesterol levels. Olezarsen sodium is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease .
Cat. No.: HY-W028350
CAS No.: 40106-12-5
Target:
Research Areas:
NSC727447 is a vinyl urea-based allosteric inhibitor of HIV reverse transcriptase-associated RNase H with IC50 values of 2.0 μM and 2.5 μM against HIV-1 and HIV-2 RNase H, respectively, and IC50 values of 100 μM and 10.6 μM against Escherichia coli and human RNase H, respectively. NSC727447 exerts allosteric inhibitory effects mainly by interacting with the region adjacent to α-helix I in the thumb subdomain of the p51 subunit of HIV-1 reverse transcriptase. Cys280, Lys281 and the RNase H primer grip region are involved in its action, and it may inhibit the catalytic activity of RNase H by altering the positioning of nucleic acid substrates or the geometry of the RNase H active site. NSC727447 can be used in studies related to HIV infection, the function of HIV reverse transcriptase RNase H, and allosteric inhibition mechanisms .
Cat. No.: HY-W060316
CAS No.: 29346-20-1
Synonyms: 3-Hydroxy-5-isopropyltropolone
Category:
Target:
Cat. No.: HY-116454
CAS No.: 1312345-89-3
Target:
Research Areas:
GSK5750 is a specific and potent HIV-1 reverse transcriptase ribonuclease H inhibitor with an IC50 value of 0.33 μM. GSK5750 is bound at the RNase H active site through a metalion chelation mechanism .
Cat. No.: HY-146364
CAS No.: 2132412-25-8
Target:
Cat. No.: HY-132572
CAS No.: 2709085-95-8
HIV-1 integrase inhibitor 9 (compound 8a) is a potent HIV-1 RNase H inhibitor with an IC50 of 12.3 μM. HIV-1 integrase inhibitor 9 shows an antiviral activity .
Cat. No.: HY-W103287
CAS No.: 6890-08-0
Target:
Research Areas:
Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively .
Cat. No.: HY-P702773
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNASEH1; RNH1; ribonuclease H1; H1RNA; RNase H1; PEOB2; ribonuclease H Type II
Species:
Human
Source:
E. coli
Cat. No.: HY-185448
CAS No.: 1246741-36-5
Target:
Research Areas:
HIV RT-IN-1 is an inhibitor of HIV integrase and HIV reverse transcriptase-associated ribonuclease H. HIV RT-IN-1 is applicable to research related to HIV-1 infection .
Cat. No.: HY-P706002
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: ZC3H12A; Zinc Finger CCCH-Type Containing 12A; Regnase-1; MCPIP1; Monocyte Chemotactic Protein-Induced Protein 1; Zinc Finger CCCH Domain-Containing Protein 12A; Endoribonuclease ZC3H12A; MCP-Induced Protein 1; FLJ23231; MCPIP-1; MCPIP; Reg1; Bifunctional Endoribonuclease And Deubiquitinase ZC3H12A; MCP-1 Treatment-Induced Protein; MCP Induced Protein 1; ribonuclease ZC3H12A; DJ423B22.1
Species:
Human
Source:
E. coli
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
