2097587-83-0
Chemical Structure
Olezarsen
Synonym(s): ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx
- CAS No.: 2097587-83-0
- Molecular Weight:8684.86
SMILES: [Olezarsen]
Biological Activity: Olezarsen (ISIS 678354; IONIS-APOCIII-LRx) is a GalNAc3-conjugated antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen decreases plasma levels of triglycerides, apolipoprotein B and non-high-density lipoprotein cholesterol. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Olezarsen | 96.60% | Olezarsen (ISIS 678354; IONIS-APOCIII-LRx) is a GalNAc3-conjugated antisense oligonucleotide. Olezarsen binds to APOC3 mRNA and induces its degradation via ribonuclease H1-mediated sense strand cleavage, thereby reducing hepatic apolipoprotein C-III (apoC-III) synthesis. Olezarsen decreases plasma levels of triglycerides, apolipoprotein B and non-high-density lipoprotein cholesterol. Olezarsen is applicable to research related to familial chylomicronemia syndrome, hypertriglyceridemia and atherosclerotic cardiovascular disease. | ||||||||||||||||||||
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