8 Results for "

rodent tumor models

" in MedChemExpress (MCE) Product Catalog:
Products (8)

8 Results for "rodent tumor models" in MCE Product Catalog:

4
DMBA
DMBA
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4 Cited Publications
Cat. No.: HY-W011845
CAS No.: 57-97-6
Synonyms: 7,12-DMBA; 7,12-Dimethylbenzanthracene
Target:  

Environmental Pollutants c-Myc

Research Areas:  

Cancer

DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
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2
Spexin
Spexin
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2 Cited Publications
Cat. No.: HY-P1723
CAS No.: 1370290-58-6
Synonyms: Neuropeptide Q
Target:  

Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy

Research Areas:  

Cardiovascular Disease Neurological Disease

Spexin (Neuropeptide Q) is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin can function through both central and peripheral actions. Spexin upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .
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1
Poricoic acid A
Poricoic acid A
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1 Cited Publications
Cat. No.: HY-N2995
CAS No.: 137551-38-3
Synonyms: Poricoic acid A(F)
Category:  

Triterpenes Terpenoids Polyporaceae Poria cocos Plants Disease Research Fields Cancer

Target:  

NF-κB Keap1-Nrf2 AMPK TGF-beta/Smad Reactive Oxygen Species (ROS)

Poricoic acid A can be isolated from Poria cocos. Poricoic acid A is an orally active anti-tumor agent. Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/AxlNFκB/Nrf2 axis. Poricoic acid A also attenuatea fibroblast activation and abnormal extracellular matrix remodeling in renal fibrosis by activating AMPK and inhibiting Smad3. Poricoic acid A significantly reduces the magnitude of rise in serum creatinine and urea levels in rat model when combined with Melatonin. Poricoic acid A ameliorates renal fibrosis and podocyte injury by attenuating oxidative stress and inflammation through regulating NF-κB and Nrf2 in IRI rodent model in combination with Melatonin .
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PTX-35
PTX-35
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Cat. No.: HY-P991455

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

PTX-35 is a costimulatory agonist antibody targeting TNFRSF25 as well as an immune activator that selectively regulates activated CD8 + T cells. PTX-35 enhances the expansion, survival and effector functions of T cells, while reducing the inhibitory activity of regulatory T cells and impairing their stability. PTX-35 exhibits anti-tumor activity, effectively delaying tumor progression and prolonging survival. PTX-35 has a synergistic effect with anti-OX40 agonist antibodies. PTX-35 can be widely used in research on related diseases such as colon cancer and melanoma .
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DMBA (Standard)
DMBA (Standard)
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Cat. No.: HY-W011845R
CAS No.: 57-97-6
Synonyms: 7,12-DMBA (Standard); 7,12-Dimethylbenzanthracene (Standard)
Target:  

c-Myc Reference Standards

Research Areas:  

Cancer

DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH). DMBA is used to induce tumor formation in various rodent models .
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Spexin TFA
Spexin TFA
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Cat. No.: HY-P1723A
Synonyms: Neuropeptide Q TFA
Target:  

Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy

Research Areas:  

Cardiovascular Disease Metabolic Disease

Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy .
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Plenolin
Plenolin
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Cat. No.: HY-165375
CAS No.: 34257-95-9
Target:  

Others

Research Areas:  

Cancer

Plenolin is an anticancer agent. Plenolin exhibits inhibitory activity against human epidermoid carcinoma cells. Plenolin shows in vivo antitumor activity against ascites carcinosarcoma and lymphocytic leukemia in rodent models. Plenolin can be used for research related to ascites tumors and leukemia .
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HMBD-002
HMBD-002
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Cat. No.: HY-P992369

Target:  

VISTA

Research Areas:  

Cancer

HMBD-002 is an Fc-independent, non-depleting IgG4 subclass antibody that targets VISTA and VSIG3. It is widely used in research related to various solid tumors, including colon cancer, triple-negative breast cancer, and non-small cell lung cancer. HMBD-002 blocks the interactions of VISTA with VSIG3 and LRIG1, relieves immunosuppression without depleting VISTA-positive cells, activates the cytotoxic program of CD8 + T cells, and drives the type I interferon signaling pathway. HMBD-002 reprograms tumor-associated macrophages to the M1 phenotype, reduces tumor infiltration of inhibitory myeloid cells, thereby significantly inhibiting tumor growth and improving survival. HMBD-002 is well tolerated in rodent and non-human primate animal models .
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