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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
solid-state cyclization
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "solid-state cyclization" in MCE Product Catalog:
Cat. No.: HY-113278S
Research Areas:
Leucyl-phenylalanine- 13C6, 15N TFA is the 13C, 15N-labeled Leucyl-phenylalanine (HY-113278). Leucyl-phenylalanine is a linear dipeptide composed of L-leucine and L-phenylalanine, and also serves as a cyclization substrate. Leucyl-phenylalanine is an incomplete degradation product generated during protein breakdown or catabolism. Leucyl-phenylalanine undergoes heat-induced solid-state cyclization via an autocatalytic mechanism to form its cyclic diketopiperazine analog .
Cat. No.: HY-141460
CAS No.: 24787-73-3
Synonyms: Ile-Ala; L-Isoleucyl-L-alanine
Target:
Research Areas:
H-Ile-Ala-OH (Ile-Ala; L-Isoleucyl-L-alanine) is a linear aliphatic dipeptide and self-reactive cyclization reagent that self-assembles into amorphous films or spherical structures from specific solvents. H-Ile-Ala-OH also serves as a precursor for the synthesis of the cyclic peptide cyclo (L-isoleucyl-L-alanine) (HY-N9251). H-Ile-Ala-OH undergoes solid-state cyclization when heated above 206 °C, and its initiation temperature is closely related to the size of side-chain substituents .
Cat. No.: HY-167680
CAS No.: 483369-58-0
Synonyms: GSK823093
Target:
Research Areas:
Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings .
Cat. No.: HY-113278R
CAS No.: 3063-05-6
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
