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Results for "

thyrotropin-releasing hormone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Thyroid Hormone Receptor (14) TSH Receptor (1) Amino Acid Derivatives (1) Apoptosis (3) Biochemical Assay Reagents (3) Endogenous Metabolite (3) Fluorescent Dye (1) Isotope-Labeled Compounds (1) Prolyl Endopeptidase (PREP) (2)
By Research Areas:	Cancer (2) Endocrinology (10) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (13)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Thyroid Hormone Receptor PTHR GHR Nuclear Hormone Receptor 4A/NR4A TSH Receptor MCHR1 (GPR24) GHSR Hormone-Sensitive Lipase (HSL) GnRH Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0002

Protirelin 4 Publications Verification thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-B0596

Taltirelin 1 Publications Verification TA-0910	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-P3960

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

HY-P0002A

Protirelin acetate 4 Publications Verification thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

HY-B0596A

Taltirelin acetate 1 Publications Verification TA-0910 acetate	Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC₅₀ at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release) with an EC₅₀ value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .

HY-P10485

Glp-Asn-Pro-AMC	Thyroid Hormone Receptor	Neurological Disease
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a K_i value of 0.97 μM .

HY-P3962

[Phe2]-TRH	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

HY-15113A

Y-29794 tosylate	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .

HY-P3964

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .

HY-P3969

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release .

HY-W009673

Boc-Pyr-OH N-Boc-L-pyroglutamic acid	Amino Acid Derivatives Biochemical Assay Reagents	Others
Boc-Pyr-OH is a Boc-protected pyroglutamic acid derivative. Boc-Pyr-OH stabilizes the amino group of pyroglutamic acid through the Boc protecting group, preventing unwanted reactions during peptide synthesis. Boc-Pyr-OH can be used in the research of thyrotropin-releasing hormone (TRH) synthesis .

HY-118117

Rovatirelin S0373	Thyroid Hormone Receptor	Endocrinology
Rovatirelin is an orally active thyrotropin-releasing hormone (TRH) analog. Rovatirelin binds to the human TRH receptor with a K_i value of 702 nM. Rovatirelin can be used to study spinocerebellar degeneration (SCD) .

HY-119495

JTP 2942	Thyroid Hormone Receptor	Neurological Disease
JTP 2942 is a thyrotropin-releasing hormone analogue. JTP 2942 can promote the release of Acetylcholine in the hippocampus and frontal cortex of rats. JTP 2942 possesses neuroprotective and cognitive-improving activities. JTP 2942 dose-dependently improves motor and neurological deficits in rat models of chronic focal cerebral ischemia. JTP 2942 can be used for the research of cerebral ischemia, motor neuron diseases, and other related conditions .

HY-P4367

TRH-AMC	Fluorescent Dye	Others
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .

HY-19154

Montirelin NS 3	Thyroid Hormone Receptor	Neurological Disease
Montirelin (NS 3) is an analog of thyrotropin-releasing hormone (TRH), and exhibits high affinity to TRH receptors. Montirelin exhibits potent effects to central nervous system (CNS) .

HY-107380A

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

HY-B0596S

Taltirelin-13C,d3 TA-0910-¹³C,d₃	Isotope-Labeled Compounds Thyroid Hormone Receptor Apoptosis	Neurological Disease Endocrinology
Taltirelin- ¹³C,d₃ (TA-0910- ¹³C,d₃) is ¹³C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC₅₀ of 910 nM and EC₅₀ of 36 nM for stimulating an increase in cytosolic Ca ²⁺ concentration (Ca ²⁺ release).

HY-117178

TA 0910 acid-type	Thyroid Hormone Receptor	Metabolic Disease
TA 0910 acid-type is a metabolite of TA 0910. TA-0910 is a metabolically stable analogue of thyrotropin releasing hormone (TRH) .

HY-15113

Y-29794	Prolyl Endopeptidase (PREP)	Neurological Disease Cancer
Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC₅₀ of 3 nM and a K_i of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) .

HY-E70395

Prolyl endopeptidase PE; PEP	Biochemical Assay Reagents	Neurological Disease
Prolyl Endopeptidase, highly active in brain and other tissues, catabolizes proline-containing peptides such as substance P, neurotensin, luteinizing hormone-releasing hormone, thyrotropin releasing hormone, bradykinin and angiotensin II. Prolyl Endopeptidase can be used for study of neuropsychiatric diseases such as stress disorder, depression, and schizophrenia .

HY-122353

Orotirelin CG 3509	Thyroid Hormone Receptor	Neurological Disease
Orotirelin (CG 3509) is a thyrotrophin-releasing hormone (TRH) analogue. Orotirelin can be used in the study of neurological diseases .

HY-106744

Azetirelin YM-14673	Biochemical Assay Reagents	Metabolic Disease
Azetirelin (YM-14673) is an analogue of thyrotropin-releasing hormone (TRH) .

Cat. No.	Product Name

HY-L211

Human Hormone Compound Library	86 compounds
Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases. MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.

Human Hormone Compound Library

86 compounds

Hormones are a class of biologically active substances secreted by endocrine gland cells, which are transported through the circulatory system to various parts of the body, and precisely act on specific target organs or cells, playing a crucial role in regulating the growth, development, metabolism, and reproduction of organisms. The mechanisms of hormone action are diverse and complex. Some hormones (such as corticosteroids, vitamin D, and thyroid hormones) can enter the cell interior and interact with receptors in the nucleus, thereby regulating gene expression and affecting cell function. Other hormones (such as growth hormone and thyrotropin-releasing hormone) bind directly to receptors on the cell surface, exerting their effects by regulating enzyme activity or influencing the state of ion channels. Additionally, hormones play a key role in the study of endocrine and metabolic diseases, and are closely related to the development of diseases such as diabetes and thyroid diseases.

MCE has included 86 human hormone compounds, which is of great significance for the study of human metabolic pathways, and can also be used to build a metabonomics database.

Boc-Pyr-OH N-Boc-L-pyroglutamic acid	Biochemical Assay Reagents
Boc-Pyr-OH is a Boc-protected pyroglutamic acid derivative. Boc-Pyr-OH stabilizes the amino group of pyroglutamic acid through the Boc protecting group, preventing unwanted reactions during peptide synthesis. Boc-Pyr-OH can be used in the research of thyrotropin-releasing hormone (TRH) synthesis .

Thyrotropin-Releasing Hormone (TRH), Free Acid 2 Publications Verification TRH-OH	Peptides	Neurological Disease Metabolic Disease
Thyrotropin-Releasing Hormone (TRH), Free Acid (TRH-OH) is a physiological metabolite of Thyrotropin-Releasing Hormone.

Protirelin 4 Publications Verification thyrotropin-releasing-hormone; TRH	Thyroid Hormone Receptor Endogenous Metabolite	Inflammation/Immunology Endocrinology
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

(Glu2)-TRH	Thyroid Hormone Receptor Endogenous Metabolite	Neurological Disease
(Glu2)-TRH, a metabolically stable analogue of Thyrotropin-releasing hormone (TRH; HY-P0002), is a negative modulator for the cholinergic effect of TRH in the mouse brain. (Glu2)-TRH significantly attenuates TRH-induced hippocampal extracellular acetylcholine release. (Glu2)-TRH is not metabolized by thyroliberinase. (Glu2)-TRH manifests neuroprotective, antidepressant, anticonvulsant in the CNS .

Protirelin acetate 4 Publications Verification thyrotropin-releasing-hormone acetate; TRH acetate	Thyroid Hormone Receptor	Inflammation/Immunology Endocrinology
Protirelin Acetate is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.

Glp-Asn-Pro-AMC	Thyroid Hormone Receptor	Neurological Disease
Glp-Asn-Pro-AMC is an inhibitor of thyrotropin-releasing hormone degrading enzyme (TRH-DE) with a K_i value of 0.97 μM .

[Phe2]-TRH	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

TRH Precursor Peptide	Endogenous Metabolite	Endocrinology
TRH Precursor Peptide is a precursor peptide of thyrotropin-releasing hormone (TRH). TRH Precursor Peptide formation of TRH in rat brain and pituitary is zinc-dependent .

Prepro-TRH-(160-169)	Thyroid Hormone Receptor	Neurological Disease Endocrinology
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release .

TRH-AMC	Fluorescent Dye	Others
TRH-AMC is a fluorogenic substrate used in a coupled assay for thyrotropin-releasing hormone(TRH)-degrading ectoenzyme .

PGlu-3-methyl-His-Pro-NH2 TFA A-42872 TFA	TSH Receptor	Endocrinology
PGlu-3-methyl-His-Pro-NH2 TFA (A-42872 TFA), the modified thyrotropin-releasing hormone (TRH) peptide, enhances binding to pituitary TRH receptors and increases stimulation of thyroid-stimulating hormone (TSH) release from the pituitary. The in vitro permeability of PGlu-3-methyl-His-Pro-NH2 TFA through rat skin is increased in the presence of enhancers Ethanol and Cineole .

Cat. No.	Product Name	Category	Target	Chemical Structure