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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
trace amines
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "trace amines" in MCE Product Catalog:
6
6 Publications Verification
Synonyms: 3-O-methyl Dopamine hydrochloride
Category:
Target:
6
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (Ki: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .
3
3 Cited Publications
Research Areas:
RO5256390 is an orally effective trace amine associated receptor 1 (TAAR1) agonist. RO5256390 exhibits pro-cognitive and antidepressant-like properties in rodent and primate models, showing similar brain activation patterns to Olanzapine (HY-14541). RO5256390 blocks compulsive overeating behavior in rats. RO5256390 can inhibit ATP (HY-B2176)-induced TNF secretion in mouse bone marrow-derived macrophages .
2
Research Areas:
Ralmitaront (RO6889450) is an orally active agonist of trace amine-associated receptor 1 (TAAR1) with a EC50 value of 110.4 nM. Ralmitaront has antipsychotic, cognitively improvement, and antidepressant activity in rodents. Ralmitaront can be used as a neurosuppressant in the study of neuro-related diseases, such as schizophrenia (SCZ), schizoaffective disorder .
1
Research Areas:
Ro 5212773 (EPPTB) is a potent and selective trace amine-associated receptor 1 (TAAR1) antagonist (Ki=0.9 nM for mouse TAAR1), with no significant effects on other TAARs. TAAR1 is a G protein-coupled receptor (GPCR) that is nonselectively activated by endogenous metabolites of amino acids .
1
1 Cited Publications
Synonyms: 3-O-methyl Dopamine-d4 hydrochloride
Cat. No.: HY-D0874
CAS No.: 68399-78-0
Cat. No.: HY-B2132S1
CAS No.: 340257-60-5
Category:
Alkaloids Monophenols Neurological Disease Other Alkaloids Phenols Endogenous metabolite Disease Research Fields
Target:
Research Areas:
RTI-7470-44 is an orally active and blood-brain barrier-permeable antagonist of trace amine-associated receptor 1 (hTAAR1) with a Ki of 0.3 nM. RTI-7470-44 inhibits hTAAR1-mediated cAMP production and signal transduction (IC50 = 8.4 nM), and blocks hTAAR1-mediated GIRK current responses. RTI-7470-44 increases the spontaneous firing frequency of dopaminergic neurons and reduces collagen-induced platelet aggregation. RTI-7470-44 can be used in studies related to Parkinson's disease and gastric emptying .
Synonyms: 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine (Standard)
Target:
Cat. No.: HY-W005394
CAS No.: 20388-87-8
Research Areas:
2-Phenylpropan-1-amine hydrochloride, a phenethylamine compound, is an agonist of the human trace amine-associated receptor 1 (TAAR1) .
Research Areas:
RO5203648 is a potent and highly selective partial agonist of TAAR1 (Trace amine-associated receptor 1) with high affinity. RO5203648 demonstrates a novel paradigm for neuropsychiatric research .
Cat. No.: HY-103638R
CAS No.: 1477-68-5
Synonyms: 3-O-methyl Dopamine hydrochloride (Standard)
Category:
Research Areas:
N-Methylphenethylamine (NMPEA) hydrochloride is a potent TAAR1 agonist. N-Methylphenethylamine hydrochloride also is a trace amine neuromodulator .
Cat. No.: HY-160001A
Research Areas:
ZH8659 hydrochloride is a trace amine-associated receptor 1 (TAAR1)-Gq agonist. ZH8659 hydrochloride can be used for the research of neurological disorders .
Target:
Cat. No.: HY-160001
CAS No.: 885466-70-6
Research Areas:
ZH8659 is a trace amine-associated receptor 1 (TAAR1) –Gq agonist. ZH8659 can be used for the research of schizophrenia .
Cat. No.: HY-W502657
CAS No.: 910387-04-1
Research Areas:
ZH8667 is a trace amine-associated receptor 1 (TAAR1) –Gs agonist. ZH8667 can be used for the research of schizophrenia .
Cat. No.: HY-B2132S
CAS No.: 362049-48-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
