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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
translation elongation
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "translation elongation" in MCE Product Catalog:
37
37 Publications Verification
Synonyms: Omacetaxine mepesuccinate; HHT
Category:
Alkaloids Pyrrole Alkaloids Plants Cephalotaxaceae Disease Research Fields Cancer Cephalotaxus fortunei Hooker
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2
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2
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1
1 Cited Publications
Cat. No.: HY-18979
CAS No.: 134869-15-1
Target:
Category:
Infection Alkaloids Neurological Disease Plants Sprekelia formosissima (L.) Herb. Disease Research Fields Isoquinoline Alkaloids Amaryllidaceae
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Cat. No.: HY-80003
CAS No.: 1469988-75-7
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QL47, a broad-spectrum antiviral agent, inhibits dengue virus and other RNA viruses. QL47 selectively inhibits eukaryotic translation. QL47 is a potent covalent inhibitor of BTK with an IC50 of 7 nM .
Synonyms: ML246
Target:
Research Areas:
Metarrestin (ML246) is an orally active, first-in-class and specific perinucleolar compartment inhibitor. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2. Metarrestin blocks metastatic development and extends survival in mouse cancer models .
Cat. No.: HY-172815
CAS No.: 3079913-81-5
Research Areas:
IDB-001 is a human ribosomal peptidyl transferase center (PTC) inhibitor that induces conformational changes and blocks translational elongation in specific sequence contexts through complementary interactions with Asp/Glu residues in nascent polypeptides. IDB-001 preferentially stalls ribosomes at positions containing acidic peptide motifs, thereby inhibiting cancer cell proliferation, and activates the integrated stress response via eIF2α phosphorylation at high concentrations. In addition, IDB-001 mildly triggers ribotoxic stress responses through phosphorylation of JNK and p38. IDB-001 has been applied to mechanistic studies of triple-negative breast cancer .
Cat. No.: HY-P10396
CAS No.: 849352-44-9
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Cat. No.: HY-175164
SVC112 is a translation elongation inhibitor that prevents the cyclic dissociation of EF2 from the ribosome, thereby inhibiting the elongation step of translation. SVC112 shows activity in growth inhibition among cancer cell lines of various origins (acute myeloid leukemia (AML), multiple myeloma (Myeloma), colorectal cancer (CRC), and head and neck squamous cell carcinoma (HNSCC)). SVC112 preferentially impedes ribosomal processing of mRNAs, and decreaseds CSC-related proteins including Myc and Sox2. SVC112 induces apoptosis in hematologic cancer cell lines, while phosphorylation of c-Myc correlates with sensitivity to SVC112 in colorectal cancer cell lines. SVC112 inactivates HNSCC stem cells in vitro and prevents the regrowth of HNSCC tumor xenografts in mice. SVC112 can be used for the study of HNSCC .
Cat. No.: HY-14944R
CAS No.: 26833-87-4
Synonyms: Omacetaxine mepesuccinate (Standard); HHT (Standard)
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Cat. No.: HY-114489B
Category:
Infection Alkaloids Neurological Disease Plants Sprekelia formosissima (L.) Herb. Disease Research Fields Isoquinoline Alkaloids Amaryllidaceae
Target:
Cat. No.: HY-B1350S
Synonyms: Fusidate-d6; SQ-16603-d6
Cat. No.: HY-106801
CAS No.: 110883-46-0
Synonyms: RP 49532
Category:
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Cat. No.: HY-B1350AR
CAS No.: 751-94-0
Synonyms: Sodium fusidate (Standard); SQ-16360 (Standard)
Category:
Target:
Cat. No.: HY-P72178
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EEF1A1; Eukaryotic translation elongation Factor 1 Alpha 1-Like 14; Prev. EEF1A; translation elongation Factor 1 Alpha 1-Like 14; Prev. LENG7; Epididymis Secretory Sperm Binding Protein; Prev. EF1A; elongation Factor 1 Alpha Subunit; elongation Factor 1-A
Species:
Human
Source:
E. coli
Cat. No.: HY-P76898
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EEF1B2; EEF1B; Eukaryotic translation elongation Factor 1 Beta 2; EF1B; elongation Factor 1-Beta; Eukaryotic translation elongation Factor 1 Beta 1; EEF-1B Alpha; EEF1B1; EF-1-Beta
Species:
Human
Source:
E. coli
Cat. No.: HY-P704289
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: EEF2; Polypeptidyl-TRNA Translocase; Prev. EF2; Epididymis Secretory Sperm Binding Protein; elongation Factor 2; SCA26; EEF-2; Eukaryotic translation elongation Factor 2; EF-2
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
