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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
tumor-infiltrating lymphocyte
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "tumor-infiltrating lymphocyte" in MCE Product Catalog:
Cat. No.: HY-P990690
CAS No.: 2407760-40-9
Synonyms: MEDI-5752
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Cat. No.: HY-153598
CAS No.: 2782022-40-4
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LD4172 is a selective RIPK1 PROTAC degrader with a Ki of 4.8 nM. LD4172 induces RIPK1 protein degradation via ternary complex formation with RIPK1 and VHL E3 ligase, driving ubiquitination and proteasomal breakdown. LD4172 abrogates TNF-induced classical NF-κB signaling in TRAF2-deficient cells, impairing IκBα phosphorylation and degradation, and reducing IL-8 production. LD4172 induces apoptosis and immunogenic cell death in tumor cells, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy. LD4172 acts as a chemical probe for investigating RIPK1 scaffolding functions. LD4172 can be used for the research of melanoma, colon cancer .
Cat. No.: HY-P991179
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Cat. No.: HY-P3813
CAS No.: 166188-11-0
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Cat. No.: HY-P990569
CAS No.: 1783801-93-3
Synonyms: MK-6018
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Cat. No.: HY-155681
CAS No.: 2922115-32-8
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SWS1 is a d-(+)-biotin-conjugated PD-L1 inhibitor (IC50: 1.8 nM) with anticancer activity. SWS1 can increase the number of tumor-infiltrating lymphocytes and exhibit anti-tumor efficacy in the B16-F10 mouse model (TGI=66.1%) .
Cat. No.: HY-106187
CAS No.: 156251-11-5
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Cat. No.: HY-P991406
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Cat. No.: HY-106187B
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Cat. No.: HY-P992511
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Cat. No.: HY-P992361
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Cat. No.: HY-P991911
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Cat. No.: HY-P991781
Cat. No.: HY-183844
CAS No.: 2792206-44-9
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C5F2-HCB is a CYP-mediated inhibitor of the biosynthesis of arachidonic acid epoxygenase product (±) 14,15-EET (HY-150084), with an IC50 of 3.1 μM. C5F2-HCB inhibits EET-driven oxidative phosphorylation (OXPHOS) associated with tumor hypoxia, converting an immunologically "cold" tumor microenvironment into a "hot" one. C5F2-HCB reverses the immune-excluded tumor microenvironment in ER +HER2 − breast cancer allograft models. C5F2-HCB can be used in research related to ER +HER2 − breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
